Faecal blood loss during administration of acetylsalicylic acid, ketoprofen and two new ketoprofen sustained-release compounds.

Abstract:

:The influence of one week's treatment with acetylsalicylic acid, ketoprofen, ketoprofen sustained-release capsules (Biovail capsules), and ketoprofen sustained-release tablets (IBP tablet) on gastrointestinal bleeding was investigated in 41 healthy male volunteers by means of a radiochromium assay. The physiological faecal bleeding was 0.10 to 0.90 ml/day (99% confidence limits). It appeared that faecal bleeding during treatment with acetylsalicylic acid medication was greater than bleeding during medication with ketoprofen capsules in equipotent dosage, the latter being in turn causing significantly more bleeding than during medication with the newly developed Biovail capsules. The most modest faecal bleeding (0.8 ml/day) was seen with IBP tablets.

journal_name

Scand J Rheumatol

authors

Ranløv PJ,Nielsen SP,Bärenholdt O

doi

10.3109/03009748309098550

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

280-4

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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    doi:

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    更新日期:1988-01-01 00:00:00

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    doi:10.3109/03009749509095162

    authors: Hansen SE

    更新日期:1995-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

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    更新日期:1978-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909095410

    authors: Hansson HA,Petruson B,Petruson K

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3109/03009748609102088

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    pub_type: 杂志文章,随机对照试验

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  • Influence of auranofin on lymphocyte membrane fluidity in rheumatoid arthritis. A fluorescence polarization study.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909102104

    authors: Beccerica E,Piergiacomi G,Curatola G,Ferretti G

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    journal_title:Scandinavian journal of rheumatology

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    authors: Inoue T,Kanayama Y,Katoh N,Ohe A,Amatsu K,Okamura M,Horiguchi T

    更新日期:1981-01-01 00:00:00

  • Reactivation of inactive systemic lupus erythematosus.

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    pub_type: 杂志文章

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    authors: Aranow C,Emy J,Barland P

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709165269

    authors: Hagberg M,Hagner IM,Bjelle A

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    pub_type: 杂志文章,多中心研究

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112353

    authors: Trang LE,Lövgren O,Bendz R,Mjös O

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    pub_type: 杂志文章

    doi:10.1080/03009740701716843

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748509165502

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    更新日期:1985-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

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    authors: Kvarstein B,Blichfeldt P

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209095055

    authors: Fassbender HG,Seibel M,Hebert T

    更新日期:1992-01-01 00:00:00

  • Weight-bearing physical activity, calcium intake, systemic glucocorticoids, chronic inflammation, and body constitution as determinants of lumbar and femoral bone mineral in juvenile chronic arthritis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950155733

    authors: Kotaniemi A,Savolainen A,Kröger H,Kautiainen H,Isomäki H

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    pub_type: 杂志文章

    doi:10.3109/03009748309102907

    authors: Törnkvist H,Nilsson OS,Bauer FC,Lindholm TS

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  • Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2012.670263

    authors: Fan LY,He DY,Wang Q,Zong M,Zhang H,Yang L,Sun LS

    更新日期:2012-10-01 00:00:00

  • Skin extensibility and consistency in patients with Ehlers-Danlos syndrome and benign joint hypermobility syndrome.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740802520714

    authors: Remvig L,Duhn PH,Ullman S,Kobayasi T,Hansen B,Juul-Kristensen B,Jurvelin JS,Arokoski J

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