Treatment of intravenous immunoglobulin-resistant Kawasaki disease with methotrexate.

Abstract:

OBJECTIVE:To evaluate the effect of low-dose oral methotrexate (MTX) as treatment for patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). METHODS:The subjects were four patients with KD, aged 8 months to 8 years old, who showed persistent disease after treatment with high-dose IVIG (2 g/kg) and aspirin (100 mg/kg). These patients were re-treated with IVIG and were also treated with IV dexamethasone (0.3 mg/kg). IV dexamethasone induced defervescence in three patients, but fever recurred upon discontinuing the steroid. One patient showed no response to either IVIG or dexamethasone. All patients were subsequently treated weekly with low-dose oral MTX [10 mg/body surface area (BSA)]. RESULTS:MTX treatment resulted in rapid defervescence, improvement in clinical symptoms, and normalization of acute-phase reactants in all patients. There was no progression of coronary artery dilatation and MTX was discontinued with no recurrence of fever. No adverse effects of MTX were observed. CONCLUSION:Low-dose oral MTX is an effective treatment for refractory KD.

journal_name

Scand J Rheumatol

authors

Ahn SY,Kim DS

doi

10.1080/03009740510026328

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

136-9

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

34

pub_type

杂志文章
  • Severe and prolonged febrile myalgia in familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and serositis. Typical attacks of FMF last 3 to 5 days. Fever and myalgia are not always improved by colchicine therapy and sometimes require steroid therapy. We present two cases of severe prolonged febrile myalgia where steroid therapy...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097400447615

    authors: Odabas AR,Cetinkaya R,Selcuk Y,Kaya H

    更新日期:2000-01-01 00:00:00

  • Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging.

    abstract::The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovi...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749509095146

    authors: Ostergaard M,Stoltenberg M,Gideon P,Wieslander S,Sonne-Holm S,Kryger P,Sonne M

    更新日期:1995-01-01 00:00:00

  • Antibodies to early EBV, CMV, and HHV6 antigens in systemic lupus erythematosus patients.

    abstract:OBJECTIVES:We investigated the antibody levels against early antigens of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV6) in systemic lupus erythematosus (SLE) patients and healthy controls, and further correlated these antibodies to haematology/biochemistry, serology, and disease activit...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2014.973061

    authors: Rasmussen NS,Draborg AH,Nielsen CT,Jacobsen S,Houen G

    更新日期:2015-01-01 00:00:00

  • Thermographic evaluation of intra-articular treatment with radioactive yttrium (90Y) in 62 rheumatoid knee joints.

    abstract::A total of 62 rheumatoid knee joints were treated with intra-articular 90Y. Results were assessed by clinical, roentgenologic and thermographic examination after a six-month follow-up. The majority of the joints had moderate roentgenologic manifestations of RA before treatment. The roentgenologic stage of the disease ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747509165443

    authors: Jalava S,Räsänen O

    更新日期:1975-01-01 00:00:00

  • Prospect for an additional laboratory criterion for rheumatoid arthritis.

    abstract::The aim of the study was to establish the benefit of an additional hypothetical laboratory criterion for rheumatoid arthritis (RA), comprising positivity for antikeratin antibody (AKA) and/or antiperinuclear factor (APF). The tests were applied to a series of 308 hospital patients with various recent-onset inflammator...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749309095137

    authors: von Essen R,Kurki P,Isomäki H,Okubo S,Kautiainen H,Aho K

    更新日期:1993-01-01 00:00:00

  • Sustained improvement of vascular endothelial function during anti-TNFalpha treatment in rheumatoid arthritis patients.

    abstract:OBJECTIVES:Vascular endothelial function and common carotid artery intima-medial thickness (CCA-IMT) are well-established surrogate markers for early atherosclerotic disease, which accounts for 30-40% of excess mortality in rheumatoid arthritis (RA) patients. Our aim was to investigate whether long-term treatment with ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740802363768

    authors: Sidiropoulos PI,Siakka P,Pagonidis K,Raptopoulou A,Kritikos H,Tsetis D,Boumpas DT

    更新日期:2009-01-01 00:00:00

  • Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis.

    abstract::Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), ch...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749609080008

    authors: Müller K,Hansen MB,Zak M,Nielsen S,Pedersen FK,de Nully P,Bendtzen K

    更新日期:1996-01-01 00:00:00

  • The effect of ibuprofen on the thickening, stiffening and development of degenerative changes in the rabbit knee following immobilization.

    abstract::The right knee of adult rabbits was immobilized in extension for 5 weeks. The rabbits were then allowed to move freely for 8 weeks. Some rabbits were given 100 mg of ibuprofen (Brufen) daily per os during the immobilization and remobilization periods. The controls were not given any drug. The development of the thickn...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009098145

    authors: Michelsson JE

    更新日期:1980-01-01 00:00:00

  • Prevalence of rheumatoid arthritis in densely and thinly populated areas in sweden.

    abstract::The prevalence of rheumatoid arthritis in 1,287 persons living in densely populated areas and 1, 287 persons living in thinly populated areas, matched as to sex, age, occupation and geographical area, was compared. The patient material was obtained in an epidemiological survey of rheumatoid arthritis (ARA definition) ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165351

    authors: Hellgren L

    更新日期:1987-01-01 00:00:00

  • Major salivary gland sonography in Sjögren's syndrome: diagnostic value of a novel ultrasonography score (0-12) for parenchymal inhomogeneity.

    abstract:OBJECTIVE:To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD:A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. On...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009740903270623

    authors: Milic VD,Petrovic RR,Boricic IV,Radunovic GL,Pejnovic NN,Soldatovic I,Damjanov NS

    更新日期:2010-03-01 00:00:00

  • Antiphosphatidylethanolamine antibodies contribute to the diagnosis of antiphospholipid syndrome in patients with systemic lupus erythematosus.

    abstract:OBJECTIVE:To evaluate the correlation between antiphosphatidylethanolamine antibodies (aPE) and some antiphospholipid antibodies (aPL)-related clinical manifestations in patients with systemic lupus erythematosus (SLE). METHODS:Patients with SLE (n=217) were tested for the presence of aPE, anticardiolipin antibodies (...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401316909594

    authors: Balada E,Ordi-Ros J,Paredes F,Villarreal J,Mauri M,Vilardell-Tarrés M

    更新日期:2001-01-01 00:00:00

  • Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study.

    abstract::Objective: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease. Studies suggest that pro-inflammatory cytokines may be attenuated by the vagus nerve through the cholinergic anti-inflammatory pathway. We aimed to evaluate the anti-inflammatory effects of short-term transcutaneous non-invasive vagus...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1764617

    authors: Drewes AM,Brock C,Rasmussen SE,Møller HJ,Brock B,Deleuran BW,Farmer AD,Pfeiffer-Jensen M

    更新日期:2021-01-01 00:00:00

  • The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome.

    abstract:OBJECTIVE:To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production. METHODS:We genotyped 111 unrelated German Caucasian patients with pSS and...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740801910353

    authors: Willeke P,Gaubitz M,Schotte H,Becker H,Domschke W,Schlüter B

    更新日期:2008-07-01 00:00:00

  • High-resolution melting analysis for the rapid detection of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China.

    abstract:OBJECTIVES:The human urate transporter 1 (URAT1, encoded by SLC22A12) was recently identified as the major absorptive urate transporter protein in the kidney responsible for regulating blood urate levels. The present study was designed to investigate the rs893006 polymorphism (GG, GT, and TT) in SLC22A12 in a total of ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740802572483

    authors: Guan M,Zhang J,Chen Y,Liu W,Kong N,Zou H

    更新日期:2009-01-01 00:00:00

  • Predicting the outcome of rheumatoid arthritis. A Soviet-Finnish co-operative study.

    abstract::The prognostically important signs and symptoms in the early stage of rheumatoid arthritis were studied in 136 patients selected and treated in Moscow and in 139 patients in Heinola, Finland. The follow-up time was 3 years. The outcome was poor in patients with early signs of radiological destruction in the joints, wi...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748409102665

    authors: Isomäki H,Martio J,Sarna S,Kiviniemi P,Akimova T,Ievleva L,Mylov N,Trofimova T

    更新日期:1984-01-01 00:00:00

  • A comparison of the content of iron in normal and rheumatoid striated muscle.

    abstract::An investigation has been carried out on the presence of iron in striated muscle from normal individuals and from patients with rheumatoid disease. The methods used for the estimation of iron required a neutron activation analysis of total iron and extraction of hemoglobin in cyanide buffer. The results disclosed that...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747609099906

    authors: Goldie IF,Bjönness T,Tiselius P,Plantin LO,Sato T

    更新日期:1976-01-01 00:00:00

  • William Musgrave's (1655-1721) system of arthritides. Did it include rheumatoid arthritis?

    abstract::Three dissertations on arthritis in Latin by the Englishman William Musgrave have been reviewed to find possible descriptions of rheumatoid arthritis. Polyarticular long-lasting joint pain in women are the cases most probable to be rheumatoid arthritis. This was found in 18 of 150 case stories. In the general sections...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 传,历史文章,杂志文章

    doi:10.3109/03009749509095162

    authors: Hansen SE

    更新日期:1995-01-01 00:00:00

  • Exogenous expression of IL-1Ra and TGF-β1 promotes in vivo repair in experimental rabbit osteoarthritis.

    abstract:OBJECTIVES:Potential gene therapy application of single and co-expression of interleukin 1 (IL-1) receptor antagonist (IL-1Ra) and transforming growth factor-β1 (TGF-β1) to alter disease progression was investigated in an in-vivo rabbit model of osteoarthritis (OA). METHOD:Sixteen young adult rabbits were randomly and...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1009942

    authors: Zhang P,Zhong ZH,Yu HT,Liu B

    更新日期:2015-01-01 00:00:00

  • Cervical myelopathy in psoriatic spondylitis.

    abstract::In psoriatic spondylitis, the complication of cervical cord compression with myelopathy is rare. We present a case of psoriatic spondylitis causing cervical myelopathy which required surgical intervention, and review the literature of reported neurological complications in psoriatic spondylitis. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749609104069

    authors: Akagi S,Saito T,Kato I,Ogawa R

    更新日期:1996-01-01 00:00:00

  • Home parenteral nutrition is beneficial in systemic sclerosis patients with gastrointestinal dysfunction.

    abstract:OBJECTIVES:To assess 12-month changes in nutritional status and quality of life (QoL) in systemic sclerosis (SSc) patients requiring home parenteral nutrition (HPN). METHOD:We conducted a retrospective, single-centre database analysis of SSc patients regarding a 12-month period of HPN at an interdisciplinary Universit...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1064543

    authors: Stanga Z,Aeberhard C,Schärer P,Kocher A,Adler S,Villiger PM

    更新日期:2016-01-01 00:00:00

  • A follow-up study of the progress of keratoconjunctivitis sicca and response to treatment in primary Sjögren's syndrome.

    abstract::Thirty-four patients with Sjögren's syndrome were retrospectively examined in order to evaluate longitudinal alterations in objective ocular disease parameters and their possible relation to systemic bromhexine treatment. Twenty-three patients (68%) were initially found to respond to peroral bromhexine treatment and w...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909099928

    authors: Kriegbaum NJ,von Linstow M,Oxholm P,Prause JU

    更新日期:1989-01-01 00:00:00

  • Pathways of destruction in metacarpal and metatarsal joints of patients with rheumatoid arthritis.

    abstract::219 metatarsal (MTP) and 69 metacarpal (MCP) capitulae obtained during surgery from patients with definite rheumatoid arthritis (RA) were histologically evaluated. This evaluation, focussing on primary pathways of joint destruction by tumor-like proliferated synovial cell masses revealed 3 pathways of aggression: Path...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209095055

    authors: Fassbender HG,Seibel M,Hebert T

    更新日期:1992-01-01 00:00:00

  • Magnetic resonance imaging-guided focused ultrasound synovectomy.

    abstract:OBJECTIVE:To investigate the feasibility of magnetic resonance imaging (MRI)-guided high power focused ultrasound (FUS) to perform synovectomy noninvasively. METHODS:Five New Zealand white male rabbit knees with experimentally induced arthritis underwent MRI-guided thermal surgery by high power (60 W/10 s) sonication....

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950155607

    authors: Foldes K,Hynynen K,Shortkroff S,Winalski CS,Collucci V,Koskinen SK,McDannold N,Jolesz F

    更新日期:1999-01-01 00:00:00

  • More evidence of distinctive features of mixed connective tissue disease.

    abstract::A comparison of clinical, immunological and HLA-D region antigen features was made between 22 patients with mixed connective tissue disease (MCTD) and 118 patients with systemic lupus erythematosus (SLE), scleroderma or primary Sjögren's syndrome. The MCTD patients had hypergammaglobulinemia more often than did those ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749309095117

    authors: Hämeenkorpi R,Ruuska P,Forsberg S,Tiilikainen R,Mäkitalo R,Hakala M

    更新日期:1993-01-01 00:00:00

  • Activated monocytes induce arthritis-associated changes in mitochondria of cultured synovial fibroblasts.

    abstract::We have recently shown that synovial fibroblasts cultured from patients with reactive or rheumatoid arthritis exhibit increased autofluorescence when compared with controls. Morphological studies suggested that this increase was related to the anomalous structure of mitochondria in cells cultured from rheumatoid or no...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748809098773

    authors: Pulkki KJ,Eerola ET,Saario RM,Toivanen A,Vuorio EI

    更新日期:1988-01-01 00:00:00

  • Arthroscopic volume of the knee joint in young male adults.

    abstract::'Arthroscopic volume' and resorption of normal saline was measured in 35 young males during routine arthroscopic examination. The average mean volume of the knee joint cavity was 103.4 ml and this volume was observed to correlate with the midpatellar circumference of the knee and the height of the patients. Mean resor...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748609092587

    authors: Visuri T,Kiviluoto O

    更新日期:1986-01-01 00:00:00

  • Pulmonary function in patients with rheumatoid arthritis.

    abstract::106 women and 38 men suffering from definite or classical rheumatoid arthritis underwent a pulmonary function test. The results were correlated to the duration and various clinical activity parameters of the disease. Pulmonary diffusion capacity was found to be reduced compared with the predicted values (p less than 0...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748209098172

    authors: Oxholm P,Madsen EB,Manthorpe R,Rasmussen FV

    更新日期:1982-01-01 00:00:00

  • Interleukin-6 and tumour necrosis factor-α cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells.

    abstract::Objective: To elucidate the roles of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in cell cycle regulation and proliferation of rheumatoid arthritis fibroblast-like synovial cells (RA-FLSs). Methods: Under stimulation with IL-6/soluble interleukin-6 receptor (sIL-6R) and TNF-α, we examined the expression ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2019.1602164

    authors: Kaneshiro K,Sakai Y,Suzuki K,Uchida K,Tateishi K,Terashima Y,Kawasaki Y,Shibanuma N,Yoshida K,Hashiramoto A

    更新日期:2019-09-01 00:00:00

  • Does ultrasound guidance improve the outcomes of arthrocentesis and corticosteroid injection of the knee?

    abstract:OBJECTIVE:The present randomized controlled trial compared arthrocentesis of the effusive knee followed by corticosteroid injection performed by the conventional anatomic landmark palpation-guided technique to the same procedure performed with ultrasound (US) needle guidance. METHODS:Sixty-four palpably effusive knees...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/03009742.2011.599071

    authors: Sibbitt WL Jr,Kettwich LG,Band PA,Chavez-Chiang NR,DeLea SL,Haseler LJ,Bankhurst AD

    更新日期:2012-02-01 00:00:00

  • The hURAT1 rs559946 polymorphism and the incidence of gout in Han Chinese men.

    abstract:OBJECTIVES:Our previous study identified rs559946, a human urate transporter 1 (hURAT1) single nucleotide polymorphism (SNP), as being significantly associated with risk of primary hyperuricaemia (HUA) in a Han Chinese population. In the current study we aimed to identify the genetic effects of rs559946 on gout suscept...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2013.808375

    authors: Li C,Yu Q,Han L,Wang C,Chu N,Liu S

    更新日期:2014-01-01 00:00:00