Activated monocytes induce arthritis-associated changes in mitochondria of cultured synovial fibroblasts.

abstract：OBJECTIVE:To investigate the effects of TNF blocking therapy on synovial immune activity in rat adjuvant arthritis (AA) by measuring mRNA expression of key macrophage and T cell cytokines during PEG sTNF-RI treatment (10mg/kg) on days 8, 10 and 12. METHODS:Paw volume was assessed every 3-4 days. Ankles were removed fo...

journal_title：Scandinavian journal of rheumatology

authors： Bush KA,Walker JS,Frazier J,Kirkham BW

更新日期：2002-01-01 00:00:00

abstract：:Primary Sjögren's syndrome (pSS) is a connective tissue disease with symptoms and serological findings often overlapping with systemic lupus erythematosus (SLE) (1). Thromboembolic events are common in SLE but not in pSS (2)(3). However, case reports have described pSS patients who developed fulminant multiorgan disea...

journal_title：Scandinavian journal of rheumatology

authors： Haga HJ,Jacobsen EM,Peen E

更新日期：2008-03-01 00:00:00

abstract：:In a series of 100 adult patients with definite rheumatoid arthritis of at most 3 years' duration and with no previous penicillamine, gold or systemic corticosteroid treatment, 50 patients were treated with D-penicillamine and 50 with gold for one yar. The dose of penicillamine was 600 mg daily. Sodium aurothiomalate ...

journal_title：Scandinavian journal of rheumatology

authors： Mäkisara P,Nissilä M,Kajander A,Martio J,von Essen R,Anttila P,Mäkisara GL

更新日期：1978-01-01 00:00:00

abstract：:To determine the reliability of tender point assessment by manual palpation in patients with fibromyalgia, and to investigate the sources of variance, tender point scores by manual palpation were obtained in 30 fibromyalgia patients by 2 investigators; the assessments were repeated after 1 week. Test-retest stability ...

journal_title：Scandinavian journal of rheumatology

authors： Jacobs JW,Geenen R,van der Heide A,Rasker JJ,Bijlsma JW

更新日期：1995-01-01 00:00:00

abstract：:It is thought that glucocorticosteroids impair the clearance of immune complexes by the mononuclear phagocyte system (MPS). We studied the effect of a five day course of prednisone (1 mg/kg body weight per day) on MPS function in 10 healthy volunteers, using soluble radiolabeled aggregates of human immunoglobulin G as...

journal_title：Scandinavian journal of rheumatology

authors： Halma C,Daha MR,Evers-Schouten JH,Pauwels EK,van Es LA

更新日期：1992-01-01 00:00:00

abstract：:The degrees of anaemia and microcytosis in 100 patients with juvenile chronic arthritis (JCA) were analysed according to the pattern of disease and its activity. Microcytosis was common (40% of patients had a mean corpuscular volume (MCV) of less than 75 fl), sometimes severe (MCV less than 65 fl in 14 patients), and ...

journal_title：Scandinavian journal of rheumatology

authors： Harvey AR,Pippard MJ,Ansell BM

更新日期：1987-01-01 00:00:00

abstract：:The evidence base for treatment of systemic vasculitis is reviewed in this article. Accurate diagnosis and evaluation of disease status is crucial to the appropriate management of these cases and disease status should be employed as a means of staging so that appropriate therapy can be offered tailored to the individu...

journal_title：Scandinavian journal of rheumatology

authors： Luqmani RA

更新日期：2000-01-01 00:00:00

abstract：:Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...

journal_title：Scandinavian journal of rheumatology

authors： Leu Agelii M,Andersson M,Jones BL,Sjöwall C,Kastbom A,Hafström I,Forslind K,Gjertsson I

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to assess the T cell cytokines IFN-gamma, IL-2, IL-4 and IL-5 in labial salivary glands (LSG) in Sjögren's syndrome (SS) and healthy controls using RT-PCR and immunohistochemistry. IFN-gamma is always or almost always produced in SS and in healthy controls. IL-2 was also found in some ...

journal_title：Scandinavian journal of rheumatology

authors： Konttinen YT,Kemppinen P,Koski H,Li TF,Jumppanen M,Hietanen J,Santavirta S,Salo T,Larsson A,Hakala M,Sorsa T

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:To provide a thorough description of team rehabilitation care and compare the structure, process, and outcomes in two specialized arthritis rehabilitation settings. METHODS:Patients with inflammatory arthritis scheduled for inpatient rehabilitation in seven specialized rehabilitation centres and three rheum...

journal_title：Scandinavian journal of rheumatology

authors： Klokkerud M,Hagen KB,Løchting I,Uhlig T,Kjeken I,Grotle M

更新日期：2012-02-01 00:00:00

abstract：:In a first stage the effect of a single dose of 3 g of salsalate on serum salicylate level was compared with a single intake of 3 g of soluble or enteric-coated acetylsalicylates in 12 healthy subjects. Salsalate seems to resorb faster than the enteric-coated forms but more slowly than the soluble forms of acetylsalic...

journal_title：Scandinavian journal of rheumatology

authors： Mielants H,Veys EM,Verbruggen G,Schelstraete

更新日期：1981-01-01 00:00:00

abstract：:Cyclic adenosine-3', 5'-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment du...

journal_title：Scandinavian journal of rheumatology

authors： Trang LE,Lövgren O,Bendz R,Mjös O

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The present randomized controlled trial compared arthrocentesis of the effusive knee followed by corticosteroid injection performed by the conventional anatomic landmark palpation-guided technique to the same procedure performed with ultrasound (US) needle guidance. METHODS:Sixty-four palpably effusive knees...

journal_title：Scandinavian journal of rheumatology

authors： Sibbitt WL Jr,Kettwich LG,Band PA,Chavez-Chiang NR,DeLea SL,Haseler LJ,Bankhurst AD

更新日期：2012-02-01 00:00:00

abstract：:The aim of the study was to establish the benefit of an additional hypothetical laboratory criterion for rheumatoid arthritis (RA), comprising positivity for antikeratin antibody (AKA) and/or antiperinuclear factor (APF). The tests were applied to a series of 308 hospital patients with various recent-onset inflammator...

journal_title：Scandinavian journal of rheumatology

authors： von Essen R,Kurki P,Isomäki H,Okubo S,Kautiainen H,Aho K

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of adalimumab, etanercept, and infliximab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX) by calculating the number needed to treat (NNT) using three different methods. METHODS:A systematic literature search of the Cochrane Library, MEDLINE...

journal_title：Scandinavian journal of rheumatology

authors： Kristensen LE,Christensen R,Bliddal H,Geborek P,Danneskiold-Samsøe B,Saxne T

更新日期：2007-11-01 00:00:00

abstract：:The subclass distribution of IgG and IgA plasma cells, and in IgG and IgA rheumatoid factor (RF) producing cells was studied in sections of synovial tissue from seropositive RA and various types of seronegative arthritis, including ankylosing spondylitis, psoriatic arthritis, and Reiter's syndrome. The study was perfo...

journal_title：Scandinavian journal of rheumatology

authors： Mellbye OJ,Vartdal F,Pahle J,Mollnes TE

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients. METHOD:We used enzyme-linked immunosorbent assay (ELISA) to investigate the prevalence of EBV early antigen diffuse (EBV-EA/D) antibodies...

journal_title：Scandinavian journal of rheumatology

authors： Draborg AH,Jørgensen JM,Müller H,Nielsen CT,Jacobsen S,Iversen LV,Theander E,Nielsen LP,Houen G,Duus K

更新日期：2012-08-01 00:00:00

abstract：:Four patients with systemic sclerosis (scleroderma) were treated with (D)-penicillamine (1.2-1.8 g/d) for 18-60 months. All patients improved. Vital capillary microscopy demonstrated that the number of visible skin capillaries increased during therapy, thus indicating a more efficient nutritional circulation. ...

journal_title：Scandinavian journal of rheumatology

authors： Mellstedt H,Fagrell B,Holm G,Björkholm M

更新日期：1977-01-01 00:00:00

abstract：:Thirty-four patients with Sjögren's syndrome were retrospectively examined in order to evaluate longitudinal alterations in objective ocular disease parameters and their possible relation to systemic bromhexine treatment. Twenty-three patients (68%) were initially found to respond to peroral bromhexine treatment and w...

journal_title：Scandinavian journal of rheumatology

authors： Kriegbaum NJ,von Linstow M,Oxholm P,Prause JU

更新日期：1989-01-01 00:00:00

abstract：:In studies on 779 fresh, unselected ANA+ sera, 50 (6.4%) were found to have anti-dsDNA antibodies, by using CIP (C. luciliae immunoperoxidase), and 84% of the 50 patients met the criteria for definite SLE. After freezing 36 of these sera for 13 +/- 1 months, only 52.8% were again positive by CIP. Using CIF (C. lucilia...

journal_title：Scandinavian journal of rheumatology

authors： Lee TK,Rothberger H

更新日期：1985-01-01 00:00:00

abstract：:Oxygen consumption was investigated during phagocytosis by leukocytes in patients suffering from rheumatoid arthritis, juvenile rheumatoid arthritis, dermatomyositis, systemic lupus erythematosus and scleroderma. Compared with the situation in normal persons, the mean oxygen consumption in the total patient group was ...

journal_title：Scandinavian journal of rheumatology

authors： Kvarstein B,Blichfeldt P

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:To evaluate chromosome damage, by means of micronucleus frequency, in dermal fibroblasts from affected and non-affected skin from systemic sclerosis (SSc) patients and from controls. METHODS:Primary fibroblast cultures were obtained by biopsy from affected and non-affected skin from SSc patients. Control fib...

journal_title：Scandinavian journal of rheumatology

authors： Martins EP,Fuzzi HT,Kayser C,Alarcon RT,Rocha MG,Chauffaille ML,Andrade LE

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:We sought to investigate the cost of living with rheumatoid arthritis (RA) and evaluate the influence of both demographics and specific disease characteristics on these costs. METHODS:We used a population-based questionnaire to survey 895 patients living in the city of Malmö, Sweden, during 2002. Data were o...

journal_title：Scandinavian journal of rheumatology

authors： Jacobsson LT,Lindroth Y,Marsal L,Juran E,Bergström U,Kobelt G

更新日期：2007-05-01 00:00:00

abstract：:Radiological examinations of the temporomandibular joints are not so often performed in patients with rheumatoid arthritis (RA). However, greater abnormalities of the mandibular head and neck may be evaluated at cervical radiography. With a new method, where the perpendicular distance from the palato-occipital line to...

journal_title：Scandinavian journal of rheumatology

authors： Redlund-Johnell I

更新日期：1987-01-01 00:00:00

abstract：:Raynaud's phenomenon, digital ischemia, antinuclear antibodies and anticardiolipin antibodies are uncommon features of malignancy. The association of all of these in a patient with malignancy has not previously been reported. We describe a 52 year old woman with non small-cell carcinoma of the lung who also had Raynau...

journal_title：Scandinavian journal of rheumatology

authors： Vaidya S,Logan JW

更新日期：2001-01-01 00:00:00

abstract：:Allergic disorders have been described in a variety of connective tissue disorders. Although an association between allergy and primary Sjögren's syndrome has been suggested, it has not been well documented. The purpose of this study was to analyze the prevalence of several types of allergic disorders in a cohort of p...

journal_title：Scandinavian journal of rheumatology

authors： Tishler M,Paran D,Yaron M

更新日期：1998-01-01 00:00:00

abstract：:X-rays of 20 finger joints, 10 foot joints and 2 wrists of 50 female patients with seropositive rheumatoid arthritis of 10-15 years' duration from 1962, 1972, 1982 and 1992 were evaluated blindly for erosions. A highly significant decline was observed in erosions in finger joints. Erosions had also declined in wrists ...

journal_title：Scandinavian journal of rheumatology

authors： Heikkilä S,Isomäki H

更新日期：1994-01-01 00:00:00

abstract：:134 cationic human IgG myeloma proteins were studied for expression of anti-DNA Idiotypic markers. 64 were studied for 16/6, F4, 3I, and 8.12, and 70 for expression of F4 and 3I. 31.3% showed at least one anti-DNA Id marker and many cationic myelomas were also positive for anti-DNA ELISA reactivity as well as anti-F(a...

journal_title：Scandinavian journal of rheumatology

authors： Williams RC Jr,Malone CC,Silvestris F

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Platelets are thought to participate in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthritis (RA). We showed recently an in vivo increase in platelet-endothelial cell interactions in mice with antigen-induced arthritis (AiA). The underlying mechanisms are not yet clear. The aim of th...

journal_title：Scandinavian journal of rheumatology

authors： Schmitt-Sody M,Metz P,Klose A,Gottschalk O,Zysk S,Hausdorf J,Veihelmann A,Jansson V

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:FURIN is a proprotein convertase enzyme that inhibits the proinflammatory function of T cells and myeloid cells. Elevated FURIN expression levels have been reported in immune-mediated diseases, such as primary Sjögren's syndrome. Here, we investigated the levels of FURIN in peripheral blood (PB) and synovial ...

journal_title：Scandinavian journal of rheumatology

authors： Valli A,Ranta N,Grönholm A,Silvennoinen O,Pesu M,Isomäki P

更新日期：2019-05-01 00:00:00