Cationic myeloma M-components frequently show cross-reacting anti-DNA, Anti-F(ab')2 and anti-nucleosome specificities.

Abstract:

:134 cationic human IgG myeloma proteins were studied for expression of anti-DNA Idiotypic markers. 64 were studied for 16/6, F4, 3I, and 8.12, and 70 for expression of F4 and 3I. 31.3% showed at least one anti-DNA Id marker and many cationic myelomas were also positive for anti-DNA ELISA reactivity as well as anti-F(ab')2. Five M-components showed anti-nucleosome reactivity and one without detectable anti-DNA Id markers showed very strong anti-nucleosome antibody which was also inhibited by DNA and Sm antigens. Anti-idiotypic antisera produced either against Id(+) anti-DNA reactive M components or F(ab')2 fragments of affinity purified SLE IgG anti-DNA showed preferential cross-reactive idiotype reactivity between Id(+) anti-DNA reactive M components. Our findings indicate that human IgG monoclonal proteins positive for several common anti-DNA Ids and possessing anti-DNA ELISA reactivity, can serve as models for SLE Id marker antigens and as a source to prepare anti-Ids from IVIG.

journal_name

Scand J Rheumatol

authors

Williams RC Jr,Malone CC,Silvestris F

doi

10.3109/03009749709115823

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

79-87

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

26

pub_type

杂志文章
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    authors: Harvey AR,Pippard MJ,Ansell BM

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    doi:10.3109/03009748509165498

    authors: Withrington RH,Sturge RA,Mitchell N

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  • Sudden death and Wegener's granulomatosis of the pituitary.

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    doi:10.1080/030097400750041433

    authors: Woywodt A,Knoblauch H,Kettritz R,Schneider W,Göbel U

    更新日期:2000-01-01 00:00:00

  • Immobilization leads to early changes in hydrostatic pressure of bone and joint. A study on experimental osteoarthritis in rabbits.

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    journal_title:Scandinavian journal of rheumatology

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    doi:10.3109/03009748809098756

    authors: Kallio PE,Michelsson JE,Björkenheim JM

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  • A radiological survey of the hips and knees in female specialist teachers of physical education.

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    journal_title:Scandinavian journal of rheumatology

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    doi:10.3109/03009747909114633

    authors: Eastmond CJ,Hudson A,Wright V

    更新日期:1979-01-01 00:00:00

  • Measurement of the viscosity of synovial fluid.

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    journal_title:Scandinavian journal of rheumatology

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    doi:

    authors: Reimann I,Stougaard J,Northeved A

    更新日期:1975-01-01 00:00:00

  • Intra-articular glucocorticoid treatment of the rheumatoid wrist. An ultrasonographic study.

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    pub_type: 临床试验,杂志文章

    doi:10.1080/030097401753180336

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    更新日期:2001-01-01 00:00:00

  • Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.

    abstract::The synthesis and release of collagenase in the presence of the neuropeptide substance P (SP) and capsaicin, were investigated in vitro using identical synoviocyte cultures from patients with rheumatoid arthritis (RA). On average 10(-12) M SP augmented statistically significantly the collagenase production by approxim...

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    pub_type: 杂志文章

    doi:10.3109/03009749109165283

    authors: Partsch G,Matucci-Cerinic M,Marabini S,Jantsch S,Pignone A,Cagnoni M

    更新日期:1991-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1080/030097400750002058

    authors: Sidi G,Shinar Y,Livneh A,Langevitz P,Pras M,Pras E

    更新日期:2000-01-01 00:00:00

  • The prevalence of rheumatoid arthritis in different geographical areas in sweden.

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    pub_type: 杂志文章

    doi:10.3109/03009747009165382

    authors: Hellgren L

    更新日期:1987-01-01 00:00:00

  • Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.

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    authors: Mayordomo L,Marenco JL,Gomez-Mateos J,Rejon E

    更新日期:2002-01-01 00:00:00

  • Glycosaminoglycans in human articular cartilage of the lower femoral epiphysis in osteoarthrosis.

    abstract::Biopsy specimens of human articular cartilage were taken from the caudal summits and from the posterior part of both epicondyles of the right lower femoral epiphysis of 20 individuals within 12 hours post mortem. 12 articular surfaces were normal and 8 included changes attributable to osteoarthrosis. In one individual...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    authors: Bjelle A

    更新日期:1977-01-01 00:00:00

  • Autoantibodies to IL-1 alpha in sera from umbilical cords, children, and adults, and from patients with juvenile chronic arthritis.

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    authors: Müller K,Hansen MB,Zak M,Nielsen S,Pedersen FK,de Nully P,Bendtzen K

    更新日期:1996-01-01 00:00:00

  • Incidence of thromboembolic events in patients with primary Sjögren's syndrome.

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    authors: Haga HJ,Jacobsen EM,Peen E

    更新日期:2008-03-01 00:00:00

  • The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis.

    abstract::Glucocorticoids (GCs) have powerful and potent anti-inflammatory and immunomodulatory effects in rheumatoid arthritis (RA) and many other diseases. These effects are mediated by up to four different mechanisms of action: cytosolic glucocorticoid receptor (cGCR)-mediated classical genomic and rapid non-genomic effects,...

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    pub_type: 杂志文章,评审

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    authors: Buttgereit F,Saag KG,Cutolo M,da Silva JA,Bijlsma JW

    更新日期:2005-01-01 00:00:00

  • Relationship of cell growth to collagen synthesis in glucocorticoid treated A/J and C57BL6/J neonatal mouse dermal fibroblasts.

    abstract::Primary cultures of neonatal dermal fibroblasts from two strains of mice (A/J and C57BL6/J) were utilized as an in vitro system to investigate the effects of glucocorticoids on cell growth and collagen synthesis. Protein and DNA synthesis were lower in untreated (control) A/J fibroblasts than in C57BL6/J fibroblasts. ...

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    pub_type: 杂志文章

    doi:10.3109/03009748309099741

    authors: Verbruggen LA,Orloff S,Rao VH,Salomon DS

    更新日期:1983-01-01 00:00:00

  • A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis.

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  • Wrist synovectomy in juvenile chronic arthritis (JCA).

    abstract::Synovectomy of 20 wrist joints in 15 patients with juvenile chronic arthritis (JCA) was performed and results were evaluated 3 (0.5-5) years after surgery. The surgical procedure consisted of synovectomy of the radiocarpal joint, around the ulnar head and in all intercarpal joints. Resection of the ulnar head was not ...

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    authors: Hanff G,Sollerman C,Elborgh R,Pettersson H

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  • Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis.

    abstract:OBJECTIVE:To evaluate the association between trabecular bone score (TBS) and new bone formation in ankylosing spondylitis (AS) patients, and to investigate whether TBS is independently associated with new bone formation. METHOD:Sixty-eight patients with AS underwent spinal magnetic resonance imaging (MRI) and dual-en...

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709102509

    authors: van den Ouweland FA,Corstens FH,van de Putte LB,Gribnau FW

    更新日期:1987-01-01 00:00:00

  • Acute non-purulent inflammatory arthropathy associated with Staphylococcus aureus abscess.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1080/03009740802520714

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    更新日期:2003-01-01 00:00:00

  • Non-nociceptive pain in rheumatoid arthritis is frequent and affects disease activity estimation: cross-sectional data from the FRAME study.

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