当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF RHEUMATOLOGY期刊下所有文献 > Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis.

Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis.

Abstract：

OBJECTIVE:To evaluate the association between trabecular bone score (TBS) and new bone formation in ankylosing spondylitis (AS) patients, and to investigate whether TBS is independently associated with new bone formation. METHOD:Sixty-eight patients with AS underwent spinal magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry of the lumbar spine to measure TBS and bone mineral density at baseline. Lateral radiographs of the cervical and lumbar spine (baseline and 2 years) were assessed for new bone formation (syndesmophyte formation and/or growth combined), and spinal MRIs were assessed for the presence or absence of fat metaplasia (FM) at the first to fourth lumbar vertebrae. The factors associated with new bone formation were analysed at the patient level and the vertebral level. RESULTS:New bone formation had developed in 17 patients (25%) at 2 year follow-up. Patients with new bone formation had a higher prevalence of FM and lower TBS at baseline than patients without new bone formation (p = 0.013 and p = 0.041). At the patient level, FM on MRI and low TBS (< 1.23) were significantly associated with new bone formation. At the vertebral level, new bone formation had developed in 25 out of 231 vertebrae (11%) after 2 years. Vertebrae with both FM on MRI and low TBS tended to have more new bone formation (p < 0.001). Syndesmophytes and low TBS (< 1.23) independently increased the risk of new bone formation at the level of individual vertebrae. CONCLUSION:At both patient and individual vertebral levels, low TBS was associated with new bone formation independently of FM on MRI.

journal_name

Scand J Rheumatol

journal_title

Scandinavian journal of rheumatology

authors

Kang KY,Jung JY,Lee SK,Min HK,Hong YS,Park SH,Ju JH

doi

10.1080/03009742.2019.1704053

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

292-300

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

49

pub_type

杂志文章

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