Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.

Abstract:

:No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-TNF-alpha treatment has been recently reported. Very recently 70 cases of tuberculosis were reported from the FDA Adverse Event Reporting System. We report a case of pulmonary miliary tuberculosis in a RA patient treated with TNF-alpha blockade. The important role of TNF-alpha in defence against tuberculosis and possible mechanisms of anti-TNF-alpha agents impairing tuberculosis immune response are discussed.

journal_name

Scand J Rheumatol

authors

Mayordomo L,Marenco JL,Gomez-Mateos J,Rejon E

doi

10.1080/030097402317255372

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

44-5

issue

1

eissn

0300-9742

issn

1502-7732

journal_volume

31

pub_type

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