Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells.

Abstract:

OBJECTIVE:To analyse the levels of interleukin-6 (IL-6) in the synovial fluids and sera of patients with osteoarthritis (OA) and to identify the IL-6-secreting cells. METHODS:Serum, synovial fluid, synovial tissue, and articular cartilage samples were collected from 49 OA patients with end-stage knee or hip OA who underwent joint replacement surgery. Serum and synovial fluid levels of IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) and IL-6-secreting cells were identified by immunohistochemistry. RESULTS:Eight out of 49 patients (16%) exhibited elevated IL-6 levels in the synovial fluids, averaging at 2022+/-526 pg/mL, while the levels in the rest of the patients averaged at 132+/-19 pg/mL. The sera levels of all patients were comparable in the 10 pg/mL range. Immunohistochemical analyses revealed plasma cells in the synovial lining of the high producers as the source of IL-6. CONCLUSIONS:Synovial fluid IL-6 levels may help to classify OA patients and may point to a subgroup with a particular impact from their immune system.

journal_name

Scand J Rheumatol

authors

Doss F,Menard J,Hauschild M,Kreutzer HJ,Mittlmeier T,Müller-Steinhardt M,Müller B

doi

10.1080/03009740701250785

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

136-9

issue

2

eissn

0300-9742

issn

1502-7732

pii

778057274

journal_volume

36

pub_type

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