The effect of daily administration of naproxen on the prothrombin complex activity in patients under long-term therapy with phenprocoumon.

Abstract:

:Out of a total of 150 patients attending an out-patient clinic for anticoagulant therapy, 12 had disorders which normally would indicate a prolonged use of an antirheumatic drug. To 6 of these patients, naproxen (1/4 g twice daily) was given while anticoagulant treatment with phenprocoumon was continued in an unchanged dosage schedule (average dose 2.1 mg/day). On the average, the prothrombin complex activity (PP%) was reduced to a stable level 10--20% below that obtained during a 2-month period before the naproxen treatment was started. No bleeding episodes or other effects were observed. Thus the simultaneous administration of naproxen caused no problems for the maintenance of a stable anticoagulant therapy.

journal_name

Scand J Rheumatol

authors

Petersen PB,Husted S,Mortensen A,Andreasen F

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

54-6

issue

1

eissn

0300-9742

issn

1502-7732

journal_volume

8

pub_type

杂志文章
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    authors: Haara MM,Arokoski JP,Kröger H,Kärkkäinen A,Manninen P,Knekt P,Impivaara O,Heliövaara M

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    doi:10.1080/03009740600904243

    authors: De Angelis R,Salaffi F,Grassi W

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    doi:10.1080/03009740701721769

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    更新日期:2008-05-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748309098554

    authors: Martio J,Kahela P

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    pub_type: 杂志文章

    doi:10.1080/03009749950155337

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    abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2018.1464206

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    更新日期:2019-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909095410

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    更新日期:1989-01-01 00:00:00

  • Atlanto-axial subluxation in rheumatoid arthritis. A study of 104 hospital patients.

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    journal_title:Scandinavian journal of rheumatology

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    doi:10.3109/03009748409111302

    authors: Haaland K,Aadland HA,Haavik TK,Vallersnes FM

    更新日期:1984-01-01 00:00:00

  • Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    authors: Liu Q,Zhao J,Tan R,Zhou H,Lin Z,Zheng M,Romas E,Xu J,Sims NA

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    更新日期:2009-05-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747709095438

    authors: von Knorring J,Selroos O

    更新日期:1977-01-01 00:00:00

  • Allergic disorders in primary Sjögren's syndrome.

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    pub_type: 杂志文章

    doi:10.1080/030097498440769

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    更新日期:1998-01-01 00:00:00

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    doi:10.3109/03009742.2015.1092580

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2016.1196500

    authors: Rome K,Clark H,Gray J,McMeekin P,Plant M,Dixon J

    更新日期:2017-05-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748309098550

    authors: Ranløv PJ,Nielsen SP,Bärenholdt O

    更新日期:1983-01-01 00:00:00

  • Prevalence and predictive factors of comorbidity in rheumatoid arthritis patients monitored prospectively from disease onset up to 20 years: lack of association between inflammation and cardiovascular disease.

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    pub_type: 杂志文章

    doi:10.3109/03009741003674180

    authors: Kapetanovic MC,Lindqvist E,Simonsson M,Geborek P,Saxne T,Eberhardt K

    更新日期:2010-01-01 00:00:00

  • IgM, IgG and IgA rheumatoid factors (antiglobulins) in early rheumatoid arthritis and their production of articular index over one year.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709165411

    authors: March RE,Kirwan JR,Reeback JS,Holborow EJ

    更新日期:1987-01-01 00:00:00

  • Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    authors: Axelsen MB,Eshed I,Østergaard M,Hetland ML,Møller JM,Jensen DV,Krintel SB,Hansen MS,Terslev L,Klarlund M,Poggenborg RP,Balding L,Pedersen SJ

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  • Cyclic nucleotides and catecholamines in rheumatoid arthritis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748309102906

    authors: Trang LE,Lövgren O,Norlund AE,Horn R,Walaas O

    更新日期:1983-01-01 00:00:00

  • The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in synovium.

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    pub_type: 杂志文章

    doi:10.3109/03009749009102116

    authors: Bröker BM,Edwards JC,Fanger MW,Lydyard PM

    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Hanff G,Sollerman C,Elborgh R,Pettersson H

    更新日期:1990-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748609092672

    authors: Hammarström L,Heigl Z,Smith CI

    更新日期:1986-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749109103019

    authors: Olmez U,Garred P,Mollnes TE,Harboe M,Berntzen HB,Munthe E

    更新日期:1991-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1080/03009742.2018.1551963

    authors: Lomborg N,Jakobsen M,Bode CS,Junker P

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    pub_type: 杂志文章

    doi:10.1080/03009740310000346

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    pub_type: 杂志文章

    doi:10.3109/03009749009095047

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    doi:10.3109/03009748309102897

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