C3 activation products, C3 containing immune complexes, the terminal complement complex and native C9 in patients with rheumatoid arthritis.

Abstract:

:Complement activation products, C9 and C3-containing circulating immune complexes (CIC), were evaluated in plasma and synovial fluid (SF) from patients with rheumatoid arthritis (RA) and osteoarthritis. C3 activation products and the fluid phase terminal complement complex were considerably elevated in SF from RA patients reaching levels five- to eighttimes that in plasma, consistant with a local activation of the whole cascade in the joints. The results emphazise the importance of detecting C3 activation by neoepitope expression instead of single fragment determinations. The concentration of native C9 was lower in synovial fluid compared with plasma, consistant with the excessive local complement activation. Increased CIC levels which correlated with the degree of complement activation were also found in the SF from the RA patients.

journal_name

Scand J Rheumatol

authors

Olmez U,Garred P,Mollnes TE,Harboe M,Berntzen HB,Munthe E

doi

10.3109/03009749109103019

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

183-9

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

20

pub_type

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