Gastrointestinal bleeding: dyspeptic symptoms and clinical course in relation to use of non-steroidal antiinflammatory drugs.

Abstract:

:To study the symptoms of NSAID-associated gastroduodenal bleeding, 94 patients (median age 71 years, range 19-90), were included in a prospective, clinical trial where hematemesis or melena from gastroduodenal ulceration or haemorrhagic/erosive gastritis were the inclusion criteria. NSAID use within one month was studied in relation to subjective symptoms prior to admission and to clinical course of the episode. Significantly fewer of the NSAID users (n = 54) than the non-users (n = 40) had experienced prior peptic ulceration or dyspeptic symptoms. Otherwise, no differences were seen between users and non-users, as regards pre-admission epigastric pain, heartburn or nausea. Also, the clinical course was similar in the two groups. We also found sporadic and regular NSAID use to be similar in this respect. These data do not support the alleged masking of ulcer symptoms by NSAIDs in bleeding ulcers.

journal_name

Scand J Rheumatol

authors

Aabakken L,Weberg R,Lygren I,Eidsvoll B,Stray N,Osnes M

doi

10.3109/03009749109096813

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

366-9

issue

5

eissn

0300-9742

issn

1502-7732

journal_volume

20

pub_type

临床试验,杂志文章
  • Intestinal permeability to different-sized polyethyleneglycols in patients with rheumatoid arthritis.

    abstract::The intestinal permeability to polyethyleneglycols (PEGs) of varying size in patients with rheumatoid arthritis has been investigated. Permeability was determined by measuring the 6-hour urinary recovery of different-sized PEGs after oral intake of PEG 400, PEG 1000, or PEG 3000. Patients with rheumatoid arthritis exc...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748309102897

    authors: Tagesson C,Bengtsson A

    更新日期:1983-01-01 00:00:00

  • Shoulder muscle strength, endurance and electromyographic fatigue in ankylosing spondylitis.

    abstract::Shoulder muscle performance was tested in 8 working ankylosing spondylitis (AS) patients and compared with 10 healthy male referents. The AS patients were all in a non-active state and had no shoulder symptoms. Electromyographic fatigue development in the descending part of the trapezius muscle was significantly faste...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709165269

    authors: Hagberg M,Hagner IM,Bjelle A

    更新日期:1987-01-01 00:00:00

  • Predictive value of a multi-biomarker disease activity score for clinical remission and radiographic progression in patients with early rheumatoid arthritis: a post-hoc study of the OPERA trial.

    abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2018.1464206

    authors: Brahe CH,Østergaard M,Johansen JS,Defranoux N,Wang X,Bolce R,Sasso EH,Ørnbjerg LM,Hørslev-Petersen K,Stengaard-Pedersen K,Junker P,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Lottenburg

    更新日期:2019-01-01 00:00:00

  • Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea.

    abstract:OBJECTIVE:To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. METHODS:Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740510026751

    authors: Joung CI,Jun JB,Chung WT,Song GG,Choe JY,Chang HK,Yoo DH

    更新日期:2006-01-01 00:00:00

  • The number needed to treat for adalimumab, etanercept, and infliximab based on ACR50 response in three randomized controlled trials on established rheumatoid arthritis: a systematic literature review.

    abstract:OBJECTIVE:To compare the efficacy of adalimumab, etanercept, and infliximab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX) by calculating the number needed to treat (NNT) using three different methods. METHODS:A systematic literature search of the Cochrane Library, MEDLINE...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,评审

    doi:10.1080/03009740701607067

    authors: Kristensen LE,Christensen R,Bliddal H,Geborek P,Danneskiold-Samsøe B,Saxne T

    更新日期:2007-11-01 00:00:00

  • (D)-penicillamine treatment in systemic sclerosis (scleroderma). Effect on nutritional capillary circulation.

    abstract::Four patients with systemic sclerosis (scleroderma) were treated with (D)-penicillamine (1.2-1.8 g/d) for 18-60 months. All patients improved. Vital capillary microscopy demonstrated that the number of visible skin capillaries increased during therapy, thus indicating a more efficient nutritional circulation. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747709095427

    authors: Mellstedt H,Fagrell B,Holm G,Björkholm M

    更新日期:1977-01-01 00:00:00

  • Rheumatoid arthritis evaluated by locomotion score. A population study.

    abstract::The effects of rheumatoid arthritis on locomotion status were assessed in an epidemiologically representative Swedish population sample. In a steady community of 12,707 inhabitants, 82 patients were found fulfilling ARA criteria 5-8 (Rome 1961). Prevalence was 0.51% for men, 0.78 for women and 0.65 in the overall popu...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749009095047

    authors: Jonsson B,Larsson SE

    更新日期:1990-01-01 00:00:00

  • Patients with primary Sjögren's syndrome treated for two months with evening primrose oil.

    abstract::Twenty-four female and 4 male patients, all fulfilling the Copenhagen criteria for primary Sjögren's syndrome (primary SS), were treated for 8 weeks with evening primrose oil (Efamol). Efamol is a seed oil which consists primarily of the n-6 essential fatty acids (EFA): cis-linoleic acid and gammalinolenic acid (GLA)....

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748609102073

    authors: Oxholm P,Manthorpe R,Prause JU,Horrobin D

    更新日期:1986-01-01 00:00:00

  • Wrist synovectomy in juvenile chronic arthritis (JCA).

    abstract::Synovectomy of 20 wrist joints in 15 patients with juvenile chronic arthritis (JCA) was performed and results were evaluated 3 (0.5-5) years after surgery. The surgical procedure consisted of synovectomy of the radiocarpal joint, around the ulnar head and in all intercarpal joints. Resection of the ulnar head was not ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749009102534

    authors: Hanff G,Sollerman C,Elborgh R,Pettersson H

    更新日期:1990-01-01 00:00:00

  • Predicting the outcome of rheumatoid arthritis. A Soviet-Finnish co-operative study.

    abstract::The prognostically important signs and symptoms in the early stage of rheumatoid arthritis were studied in 136 patients selected and treated in Moscow and in 139 patients in Heinola, Finland. The follow-up time was 3 years. The outcome was poor in patients with early signs of radiological destruction in the joints, wi...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748409102665

    authors: Isomäki H,Martio J,Sarna S,Kiviniemi P,Akimova T,Ievleva L,Mylov N,Trofimova T

    更新日期:1984-01-01 00:00:00

  • William Musgrave's (1655-1721) system of arthritides. Did it include rheumatoid arthritis?

    abstract::Three dissertations on arthritis in Latin by the Englishman William Musgrave have been reviewed to find possible descriptions of rheumatoid arthritis. Polyarticular long-lasting joint pain in women are the cases most probable to be rheumatoid arthritis. This was found in 18 of 150 case stories. In the general sections...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 传,历史文章,杂志文章

    doi:10.3109/03009749509095162

    authors: Hansen SE

    更新日期:1995-01-01 00:00:00

  • Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.

    abstract::No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097402317255372

    authors: Mayordomo L,Marenco JL,Gomez-Mateos J,Rejon E

    更新日期:2002-01-01 00:00:00

  • Major salivary gland sonography in Sjögren's syndrome: diagnostic value of a novel ultrasonography score (0-12) for parenchymal inhomogeneity.

    abstract:OBJECTIVE:To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD:A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. On...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009740903270623

    authors: Milic VD,Petrovic RR,Boricic IV,Radunovic GL,Pejnovic NN,Soldatovic I,Damjanov NS

    更新日期:2010-03-01 00:00:00

  • The relative value of spinal and thoracic mobility measurements in ankylosing spondylitis.

    abstract::The relative value of nine spinal and thoracic mobility measurements was investigated in 73 male patients with ankylosing spondylitis (AS). The value of a test was obtained by the relative ranks of validity, reliability and sensitivity to change. Validity was determined as age-adjusted correlation of the test result w...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749509099291

    authors: Viitanen JV,Kautiainen H,Suni J,Kokko ML,Lehtinen K

    更新日期:1995-01-01 00:00:00

  • Home parenteral nutrition is beneficial in systemic sclerosis patients with gastrointestinal dysfunction.

    abstract:OBJECTIVES:To assess 12-month changes in nutritional status and quality of life (QoL) in systemic sclerosis (SSc) patients requiring home parenteral nutrition (HPN). METHOD:We conducted a retrospective, single-centre database analysis of SSc patients regarding a 12-month period of HPN at an interdisciplinary Universit...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1064543

    authors: Stanga Z,Aeberhard C,Schärer P,Kocher A,Adler S,Villiger PM

    更新日期:2016-01-01 00:00:00

  • Effect of indomethacin and naproxen on the metabolism of collagen in adjuvant-induced arthritis.

    abstract::The effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [3H]-proline, both the specific and total radioactivity of [3H]-hydroxyproline being determined in skin collagen fractions and in urine. It was found that collagen synthesis and conversion of soluble t...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748109095291

    authors: Arumugham R,Bose SM

    更新日期:1981-01-01 00:00:00

  • Clinical experience of 13 cases with severe pulmonary hemorrhage in systemic lupus erythematosus with active nephritis.

    abstract::Pulmonary hemorrhage is a rare, but serious manifestation of systemic lupus erythematosus (SLE). Herein, we report 13 cases of severe pulmonary hemorrhage in SLE. Hemoptysis was present in 11 patients. All thirteen patients had active nephritis and were in the stage of nephrotic syndrome. A majority of the patients ha...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097498442406

    authors: Liu MF,Lee JH,Weng TH,Lee YY

    更新日期:1998-01-01 00:00:00

  • Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China.

    abstract:OBJECTIVE:To estimate the heritability of Kashin-Beck disease (KBD) in first-degree relatives and to identify chromosome regions likely to contain susceptibility loci for KBD. METHODS:A total of 331 probands with confirmed KBD in their pedigrees were selected from 9331 residents in 17 KBD villages of Linyou county, no...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009740903270599

    authors: Shi XW,Guo X,Lv AL,Kang L,Zhou YL,Zhang YZ,Wu XM,Bai YD

    更新日期:2010-05-01 00:00:00

  • The effect of transcutaneous electrical nerve stimulation (TNS) on joint pain in patients with rheumatoid arthritis.

    abstract::The effect of transcutaneous nerve stimulation (TNS) on joint pain was studied in patients with rheumatoid arthritis. Three different forms of TNS were used in an attempt to evaluate the influence of placebo effects. The results were evaluated by means of loading tests and from the patients' own assessments of pain re...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Mannheimer C,Lund S,Carlsson CA

    更新日期:1978-01-01 00:00:00

  • Cerebrospinal fluid levels of a proliferation-inducing ligand (APRIL) are increased in patients with neuropsychiatric systemic lupus erythematosus.

    abstract:OBJECTIVES:A proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are B-cell stimulation and survival molecules. We have investigated whether APRIL and/or BAFF activity is enhanced in the systemic and/or intrathechal compartment of patients with neuropsychiatric systemic lupus erythematosus (NPSLE)...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2010.550900

    authors: Hopia L,Thangarajh M,Khademi M,Laveskog A,Wallström E,Svenungsson E,Andersson M

    更新日期:2011-01-01 00:00:00

  • Increased chromosome damage in systemic sclerosis skin fibroblasts.

    abstract:OBJECTIVE:To evaluate chromosome damage, by means of micronucleus frequency, in dermal fibroblasts from affected and non-affected skin from systemic sclerosis (SSc) patients and from controls. METHODS:Primary fibroblast cultures were obtained by biopsy from affected and non-affected skin from SSc patients. Control fib...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009741003685640

    authors: Martins EP,Fuzzi HT,Kayser C,Alarcon RT,Rocha MG,Chauffaille ML,Andrade LE

    更新日期:2010-01-01 00:00:00

  • Pulmonary function in patients with rheumatoid arthritis.

    abstract::106 women and 38 men suffering from definite or classical rheumatoid arthritis underwent a pulmonary function test. The results were correlated to the duration and various clinical activity parameters of the disease. Pulmonary diffusion capacity was found to be reduced compared with the predicted values (p less than 0...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748209098172

    authors: Oxholm P,Madsen EB,Manthorpe R,Rasmussen FV

    更新日期:1982-01-01 00:00:00

  • Lysozyme concentrations in synovial fluid, pleural fluid and thoracic duct lymph in rheumatoid arthritis.

    abstract::Lysozyme (LZM) concentrations in synovial fluid were determined in patients with seropositive and seronegative rheumatoid arthritis (RA) and in patients whose arthritic exudates had been caused by Reiter's disease, a Yersinia enterocolitica infection, osteoarthritis, or trauma. Patients with rheumatoid disease had sig...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748509102021

    authors: Klockars M,Pettersson T

    更新日期:1985-01-01 00:00:00

  • Fear-avoidance beliefs about physical activity in adults with rheumatoid arthritis.

    abstract:OBJECTIVES:The aim of this study was to describe fear-avoidance beliefs about physical activity and explore how these beliefs correlate with sociodemographic, disease-specific, and psychosocial factors in adults with rheumatoid arthritis (RA). METHOD:This cross-sectional study is part of the Physical Activity in Rheum...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2014.932432

    authors: Lööf H,Demmelmaier I,Henriksson EW,Lindblad S,Nordgren B,Opava CH,Johansson UB

    更新日期:2015-01-01 00:00:00

  • Acute non-purulent inflammatory arthropathy associated with Staphylococcus aureus abscess.

    abstract::Case 1. A 20-year-old woman presented 4 weeks post-partum with widespread symmetrical inflammatory polyarthropathy with marked synovitis. Investigations revealed grossly raised CRP with negative immunology screen. A few days before presentation she saw her general practitioner with left-sided mastitis, which then deve...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097400750001978

    authors: Al-Allaf AW,Pullar T

    更新日期:2000-01-01 00:00:00

  • Activation of the coagulation system in connective tissue diseases. A study of [125I] fibrinogen clearance.

    abstract::Fifty-one patients with different connective tissue diseases in either active or clinically inactive phase were studied to detect the incidence of chronic or subclinical consumption coagulopathy in these forms. Every patient received intravenously 20 mu Ci of [125I] fibrinogen and the clearance of the labeled fibrinog...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112361

    authors: Canesi BA,Banfi F,Rossi AF,Sinigaglia L

    更新日期:1980-01-01 00:00:00

  • Anti-cardiolipin antibodies, Raynaud's phenomenon with digital ischemia, and non small cell carcinoma of the lung.

    abstract::Raynaud's phenomenon, digital ischemia, antinuclear antibodies and anticardiolipin antibodies are uncommon features of malignancy. The association of all of these in a patient with malignancy has not previously been reported. We describe a 52 year old woman with non small-cell carcinoma of the lung who also had Raynau...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162978

    authors: Vaidya S,Logan JW

    更新日期:2001-01-01 00:00:00

  • Anti-CD20 therapy of treatment-resistant Wegener's granulomatosis: favourable but temporary response.

    abstract::Rituximab is a genetically engineered chimeric monoclonal immunoglobulin (Ig)G1 antibody. It binds the CD20 trans-membrane surface antigen expressed by mature B cells but not by antibody secreting plasma cells, and removes the cells by activating complement, inducing cell-mediated lysis, and by apoptosis. Mainly used ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/02813430510015269

    authors: Omdal R,Wildhagen K,Hansen T,Gunnarsson R,Kristoffersen G

    更新日期:2005-05-01 00:00:00

  • Diurnal and sequential grip functions in normal subjects and effects of temperature change and exercise of the forearm on grip function in patients with rheumatoid arthritis and in normal controls.

    abstract::Rate of grip development (power), time to reach maximum grip strength and fatigue were not affected by the diurnal variation known to influence maximum grip strength and work during grip formation in normal subjects. Rheumatoid hands were less affected by exercise or temperature change of the forearm than were normal ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748209098173

    authors: Pearson R,MacKinnon MJ,Meek AP,Myers DB,Palmer DG

    更新日期:1982-01-01 00:00:00

  • Pain and pain problems among subjects with systemic lupus erythematosus in Iceland.

    abstract::This population study includes the majority of all systemic lupus erythematosus (SLE) patients in Iceland (n = 65). The study lists various self-rated pain descriptions both from a 54-item pain questionnaire and from the somatisation section of the Diagnostic Interview Schedule (DIS). Results show SLE patients to have...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749309095104

    authors: Líndal E,Thorlacius S,Stefánsson JG,Steinsson K

    更新日期:1993-01-01 00:00:00