当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF RHEUMATOLOGY期刊下所有文献 > Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea.

Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea.

Abstract：

OBJECTIVE:To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. METHODS:Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology (ACR) classification criteria for SSc were enrolled. The controls were 144 healthy, disease-free Koreans. HLA-DRB1 genotypes were assessed by the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. RESULTS:The HLA-DRB1*15 allele was increased in anti-topoisomerase I autoantibody (anti-topo I)-positive SSc patients [p = 0.003, p corrected (p(corr)) = 0.039, odds ratio (OR) = 3.43, 95% confidence interval (CI) 1.45-8.13] compared with controls. The DRB1*11 allele was also observed more frequently in anti-topo I-positive SSc than in controls (13.3% vs. 4.2%) but not statistically significant (p = 0.053, p(corr) = 0.689). In patients with SSc, the DRB1*04 allele was associated with subcutaneous calcinosis (p = 0.048, OR = 4.56, 95% CI 1.07-19.37). Patients with overlap syndrome showed a negative association with the DRB1*04 allele (p = 0.036, OR = 0.26, 95% CI 0.08-0.91). CONCLUSION:The HLA-DRB1*15 allele was associated with the development of anti-topo I-positive SSc in Koreans. In addition, the DRB1*04 allele was associated with certain clinical features in SSc patients.

journal_name

Scand J Rheumatol

journal_title

Scandinavian journal of rheumatology

authors

Joung CI,Jun JB,Chung WT,Song GG,Choe JY,Chang HK,Yoo DH

doi

10.1080/03009740510026751

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

39-43

issue

1

eissn

0300-9742

issn

1502-7732

pii

KKMV1G173333T180

journal_volume

35

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY文献大全
  • Treatment of intravenous immunoglobulin-resistant Kawasaki disease with methotrexate.

    abstract：OBJECTIVE:To evaluate the effect of low-dose oral methotrexate (MTX) as treatment for patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). METHODS:The subjects were four patients with KD, aged 8 months to 8 years old, who showed persistent disease after treatment with high-dose IVIG (2 g...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009740510026328

    authors： Ahn SY,Kim DS

    更新日期：2005-03-01 00:00:00

  • Disease activity trajectories in rheumatoid arthritis: a tool for prediction of outcome.

    abstract：:Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009742.2020.1774646

    authors： Leu Agelii M,Andersson M,Jones BL,Sjöwall C,Kastbom A,Hafström I,Forslind K,Gjertsson I

    更新日期：2021-01-01 00:00:00

  • Clinical outcome after one year following samarium-153 particulate hydroxyapatite radiation synovectomy.

    abstract：:The clinical outcome and tolerability following treatment with samarium-153 particulate hydroxyapatite was evaluated in patients with persistent rheumatoid knee synovitis. The clinical review of 18 patients treated with intra-articular samarium-153 particulate hydroxyapatite combined with triamcinolone hexacetonide wh...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009749609065647

    authors： Clunie G,Lui D,Cullum I,Ell PJ,Edwards JC

    更新日期：1996-01-01 00:00:00

  • Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity.

    abstract：OBJECTIVE:To measure serum levels of antibodies against cyclic citrullinated peptide (anti-CCP antibodies) and serum cartilage oligomeric matrix protein (COMP) in patients with early joint inflammation, and to study the correlation of these two tests with clinical measurements. METHODS:Adult patients with recent-onset...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009740310004856

    authors： Söderlin MK,Kastbom A,Kautiainen H,Leirisalo-Repo M,Strandberg G,Skogh T

    更新日期：2004-01-01 00:00:00

  • Risk factors for reported influenza and influenza-like symptoms in patients with rheumatoid arthritis.

    abstract：OBJECTIVES:To determine the prevalence and predictors of influenza and influenza-like symptoms in patients with rheumatoid arthritis (RA). METHOD:Questionnaires were sent to patients registered as having RA and they were asked to fill in per month any period and details of influenza-like symptoms and vaccination. An e...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2012.670729

    authors： Dirven L,Huizinga TW,Allaart CF

    更新日期：2012-10-01 00:00:00

  • The hURAT1 rs559946 polymorphism and the incidence of gout in Han Chinese men.

    abstract：OBJECTIVES:Our previous study identified rs559946, a human urate transporter 1 (hURAT1) single nucleotide polymorphism (SNP), as being significantly associated with risk of primary hyperuricaemia (HUA) in a Han Chinese population. In the current study we aimed to identify the genetic effects of rs559946 on gout suscept...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2013.808375

    authors： Li C,Yu Q,Han L,Wang C,Chu N,Liu S

    更新日期：2014-01-01 00:00:00

  • William Musgrave's (1655-1721) system of arthritides. Did it include rheumatoid arthritis?

    abstract：:Three dissertations on arthritis in Latin by the Englishman William Musgrave have been reviewed to find possible descriptions of rheumatoid arthritis. Polyarticular long-lasting joint pain in women are the cases most probable to be rheumatoid arthritis. This was found in 18 of 150 case stories. In the general sections...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 传,历史文章,杂志文章

    doi：10.3109/03009749509095162

    authors： Hansen SE

    更新日期：1995-01-01 00:00:00

  • The effect of transcutaneous electrical nerve stimulation (TNS) on joint pain in patients with rheumatoid arthritis.

    abstract：:The effect of transcutaneous nerve stimulation (TNS) on joint pain was studied in patients with rheumatoid arthritis. Three different forms of TNS were used in an attempt to evaluate the influence of placebo effects. The results were evaluated by means of loading tests and from the patients' own assessments of pain re...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Mannheimer C,Lund S,Carlsson CA

    更新日期：1978-01-01 00:00:00

  • Incidence and predictors of thoracic aortic damage in biopsy-proven giant cell arteritis.

    abstract：:Objective: To describe the frequency and predisposing factors of aortic structural disease among patients with biopsy-proven giant cell arteritis (GCA). Method: A retrospective review identified all patients with biopsy-proven GCA from 1998 to 2013 with aortic imaging. Kaplan-Meier methods were used to estimate cumula...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009742.2020.1786855

    authors： Koster MJ,Crowson CS,Labarca C,Warrington KJ

    更新日期：2020-09-17 00:00:00

  • The recognition of rheumatoid arthritis in the eighteenth century. The contribution of Linné and Boissier de la Croix de Sauvages.

    abstract：:Linné and Boissier de la Croix de Sauvages, two botanists and physicians of the mideighteenth century, proposed systems for the classification of diseases. Their medical works have been examined for passages suggestive of rheumatoid arthritis (RA). References to gouty arthritis dominated in Linné's works. Sauvages des...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 传,历史文章,杂志文章

    doi：10.3109/03009749309099267

    authors： Hansen SE

    更新日期：1993-01-01 00:00:00

  • The influence of antirheumatic drugs on the occurrence of peptic ulcers. A controlled study of patients with chronic rheumatic diseases.

    abstract：:46 patients who had an ulcer (verified by X-ray pictures) during treatment at the Rheumatism Foundation Hospital were compared with two patient groups of the same size. The first control group consisted of randomly selected patients who had been examined in the same way for the same indications but where the X-ray pic...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 临床试验,杂志文章

    doi：10.1080/03009748009098130

    authors： Martio J

    更新日期：1980-01-01 00:00:00

  • IgM, IgG and IgA rheumatoid factors (antiglobulins) in early rheumatoid arthritis and their production of articular index over one year.

    abstract：:An enzyme-linked immunosorbent assay was used to detect antiglobulins (rheumatoid factors, RF) of various classes in 33 patients with recently diagnosed rheumatoid arthritis and to follow their progress with 3-monthly checks for 1 year. For RF, IgA-RF and IgM-RF showed greater sensitivity than the latex test, either o...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009748709165411

    authors： March RE,Kirwan JR,Reeback JS,Holborow EJ

    更新日期：1987-01-01 00:00:00

  • Antibodies to early EBV, CMV, and HHV6 antigens in systemic lupus erythematosus patients.

    abstract：OBJECTIVES:We investigated the antibody levels against early antigens of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV6) in systemic lupus erythematosus (SLE) patients and healthy controls, and further correlated these antibodies to haematology/biochemistry, serology, and disease activit...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2014.973061

    authors： Rasmussen NS,Draborg AH,Nielsen CT,Jacobsen S,Houen G

    更新日期：2015-01-01 00:00:00

  • Cerebrospinal fluid levels of a proliferation-inducing ligand (APRIL) are increased in patients with neuropsychiatric systemic lupus erythematosus.

    abstract：OBJECTIVES:A proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are B-cell stimulation and survival molecules. We have investigated whether APRIL and/or BAFF activity is enhanced in the systemic and/or intrathechal compartment of patients with neuropsychiatric systemic lupus erythematosus (NPSLE)...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2010.550900

    authors： Hopia L,Thangarajh M,Khademi M,Laveskog A,Wallström E,Svenungsson E,Andersson M

    更新日期：2011-01-01 00:00:00

  • Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma.

    abstract：OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2010.549837

    authors： Danielides S,Mavragani CP,Katsakoulas I,Zintzaras E,Drosos AA,Vlachoyiannopoulos PG,Moutsopoulos HM

    更新日期：2011-01-01 00:00:00

  • Immunohistochemical demonstration of insulin-like growth factor I in inflammatory lesions in Wegener's granulomatosis and idiopathic midline destructive disease.

    abstract：:The immunoreactivity of the trophic peptide insulin-like growth factor I (IGF-I; somatomedin C) was mapped in nasal mucosa biopsies from three patients with Wegener's granulomatosis (WG) and one with idiopathic midline destructive disease (IMDD; idiopathic midline granuloma). Strongly increased IGF-I immuno-reactivity...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009748909095410

    authors： Hansson HA,Petruson B,Petruson K

    更新日期：1989-01-01 00:00:00

  • A follow-up study of the progress of keratoconjunctivitis sicca and response to treatment in primary Sjögren's syndrome.

    abstract：:Thirty-four patients with Sjögren's syndrome were retrospectively examined in order to evaluate longitudinal alterations in objective ocular disease parameters and their possible relation to systemic bromhexine treatment. Twenty-three patients (68%) were initially found to respond to peroral bromhexine treatment and w...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009748909099928

    authors： Kriegbaum NJ,von Linstow M,Oxholm P,Prause JU

    更新日期：1989-01-01 00:00:00

  • Systemic vasculitis associated with Fasciola hepatica infection.

    abstract：:We report the case of a 50-year-old man who presented with systemic vasculitis associated with Fasciola hepatica infection. The patient presented with severe skin, kidney, spleen, ophthalmic, and neurological compromise. An immunological examination for primary vasculitis was negative and other infections were discoun...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009740500303231

    authors： Llanos C,Soto L,Sabugo F,Gallegos I,Valenzuela O,Verdaguer J,Cuchacovich M

    更新日期：2006-03-01 00:00:00

  • Rheumatoid arthritis evaluated by locomotion score. A population study.

    abstract：:The effects of rheumatoid arthritis on locomotion status were assessed in an epidemiologically representative Swedish population sample. In a steady community of 12,707 inhabitants, 82 patients were found fulfilling ARA criteria 5-8 (Rome 1961). Prevalence was 0.51% for men, 0.78 for women and 0.65 in the overall popu...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009749009095047

    authors： Jonsson B,Larsson SE

    更新日期：1990-01-01 00:00:00

  • Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China.

    abstract：OBJECTIVE:To estimate the heritability of Kashin-Beck disease (KBD) in first-degree relatives and to identify chromosome regions likely to contain susceptibility loci for KBD. METHODS:A total of 331 probands with confirmed KBD in their pedigrees were selected from 9331 residents in 17 KBD villages of Linyou county, no...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009740903270599

    authors： Shi XW,Guo X,Lv AL,Kang L,Zhou YL,Zhang YZ,Wu XM,Bai YD

    更新日期：2010-05-01 00:00:00

  • Major salivary gland sonography in Sjögren's syndrome: diagnostic value of a novel ultrasonography score (0-12) for parenchymal inhomogeneity.

    abstract：OBJECTIVE:To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD:A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. On...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009740903270623

    authors： Milic VD,Petrovic RR,Boricic IV,Radunovic GL,Pejnovic NN,Soldatovic I,Damjanov NS

    更新日期：2010-03-01 00:00:00

  • Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol.

    abstract：OBJECTIVE:To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. METHODS:Validated baseline and follow-up QoL questionnaires were completed by...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 临床试验,杂志文章

    doi：10.1080/030097401317148516

    authors： Yeomans N,Wilson I,Långström G,Hawkey C,Naesdal J,Walan A,Wiklund I

    更新日期：2001-01-01 00:00:00

  • Use of bosentan for digital ulcers related to systemic sclerosis: a real-life retrospective French study of 89 patients treated since specific approval.

    abstract：OBJECTIVES:Ischaemic digital ulcers (DUs) are a common complication of systemic sclerosis (SSc). This study aimed to characterize patients with SSc and ongoing DUs treated with the endothelin receptor antagonist bosentan in clinical practice in France. METHOD:An observational, retrospective, longitudinal study was con...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章,多中心研究

    doi：10.3109/03009742.2014.887768

    authors： Agard C,Carpentier PH,Mouthon L,Clerson P,Gressin V,Bérezné A,Diot E,Jego P,Lok C,Sparsa A,Chatelus E,Van Kien AK,Quéré I,Sibilia J,Hachulla E

    更新日期：2014-01-01 00:00:00

  • Differences associated with age at onset in early systemic sclerosis patients: a report from the EULAR Scleroderma Trials and Research Group (EUSTAR) database.

    abstract：OBJECTIVE:The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years' duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. METHOD:Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) ...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章,多中心研究

    doi：10.1080/03009742.2018.1459830

    authors： Carreira PE,Carmona L,Joven BE,Loza E,Andréu JL,Riemekasten G,Vettori S,Balbir-Gurman A,Airò P,Walker U,Damjanov N,Matucci-Cerinic M,Ananieva LP,Rednic S,Czirják L,Distler O,Farge D,Hesselstrand R,Corrado A,Caramasc

    更新日期：2019-01-01 00:00:00

  • Glycosaminoglycans in human articular cartilage of the lower femoral epiphysis in osteoarthrosis.

    abstract：:Biopsy specimens of human articular cartilage were taken from the caudal summits and from the posterior part of both epicondyles of the right lower femoral epiphysis of 20 individuals within 12 hours post mortem. 12 articular surfaces were normal and 8 included changes attributable to osteoarthrosis. In one individual...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：

    authors： Bjelle A

    更新日期：1977-01-01 00:00:00

  • An assessment of the new "SCORE" index as a predictor of osteoporosis in women.

    abstract：BACKGROUND:The study was done to determine whether the new SCORE (Simple Calculated Osteoporosis Risk Estimation) index might reduce the utilization of bone mineral density (BMD) measurement. METHODS:989 consecutive patients who were referred by a range of physicians for BMD assessments at one of two clinics had a SCO...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/030097401750065300

    authors： Russell AS,Morrison RT

    更新日期：2001-01-01 00:00:00

  • Feasibility and estimated efficacy of blood flow restricted training in female patients with rheumatoid arthritis: a randomized controlled pilot study.

    abstract：:Objectives: The study aimed to evaluate the feasibility of a blood flow restriction (BFR) training regimen in patients with rheumatoid arthritis (RA); and to compare the effects of 4 weeks of BFR training with low-intensity strength training on muscle strength, muscle endurance, and joint pain in patients with RA. Met...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009742.2020.1829701

    authors： Jønsson AB,Johansen CV,Rolving N,Pfeiffer-Jensen M

    更新日期：2020-12-10 00:00:00

  • Comparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis.

    abstract：:Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, a microcrystalline tablet, and a capsule containing enterosoluble granules. Absorption from each preparation was good in all pat...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.3109/03009748309098554

    authors： Martio J,Kahela P

    更新日期：1983-01-01 00:00:00

  • Serum levels of IL-33 and its receptor ST2 are elevated in patients with ankylosing spondylitis.

    abstract：OBJECTIVES:The aims of this study were to measure the levels of interleukin (IL)-33 and ST2 and T-helper (Th)2-associated cytokines (IL-13, IL-4, IL-5) in patients with ankylosing spondylitis (AS), and examine the correlation of serum cytokine levels with disease activity and laboratory parameters. METHOD:Serum IL-33,...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.3109/03009742.2012.735700

    authors： Li GX,Wang S,Duan ZH,Zeng Z,Pan FM

    更新日期：2013-01-01 00:00:00

  • Cogan's syndrome with recurrent carotid and aortic aneurysms: a potentially fatal disorder mimicking Marfan syndrome.

    abstract：:Cogan's syndrome (CS) is a rare multisystemic disease characterized by vestibuloauditory dysfunction, inflammatory eye disease and vasculitis. Aortic aneurysms due to aortitis are under-recognized in CS, and are potentially fatal, with two of eight reported cases dying from aneurysm/arterial rupture. The presence of a...

    journal_title：Scandinavian journal of rheumatology

    pub_type： 杂志文章

    doi：10.1080/03009740600907923

    authors： Low AH,Su JW,Sin KY,Fong KY,Thumboo J

    更新日期：2007-01-01 00:00:00