Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol.

Abstract:

OBJECTIVE:To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. METHODS:Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4/8 weeks; maintenance: after 6 months). RESULTS:Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problems and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux, abdominal pain and indigestion symptoms. During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea. CONCLUSION:QoL in arthritis patients on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.

journal_name

Scand J Rheumatol

authors

Yeomans N,Wilson I,Långström G,Hawkey C,Naesdal J,Walan A,Wiklund I

doi

10.1080/030097401317148516

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

328-34

issue

6

eissn

0300-9742

issn

1502-7732

journal_volume

30

pub_type

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