当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF RHEUMATOLOGY期刊下所有文献 > Serum levels of IL-33 and its receptor ST2 are elevated in patients with ankylosing spondylitis.

Serum levels of IL-33 and its receptor ST2 are elevated in patients with ankylosing spondylitis.

Abstract：

OBJECTIVES:The aims of this study were to measure the levels of interleukin (IL)-33 and ST2 and T-helper (Th)2-associated cytokines (IL-13, IL-4, IL-5) in patients with ankylosing spondylitis (AS), and examine the correlation of serum cytokine levels with disease activity and laboratory parameters. METHOD:Serum IL-33, IL-13, IL-4, and IL-5 levels were assessed by sandwich enzyme-linked immunosorbent assay (ELISA), and the mRNA levels of IL-33 and ST2 were quantified by real-time quantitative polymerase chain reaction (RT-qPCR), in 43 AS samples and compared with 27 age- and sex-matched healthy controls. RESULTS:Serum IL-33, IL-13, and IL-4 levels were increased significantly in AS patients compared with controls (p < 0.01); moreover, serum IL-33 and IL-13 levels were significantly higher in patients with active AS than in those with inactive AS (p < 0.05). The serum levels of IL-5 showed no significant difference between AS patients and controls (p > 0.05). Serum IL-33 levels were positively correlated with both IL-13 (r = 0.306, p < 0.01) and IL-4 levels (r = 0.432, p < 0.01). The mRNA levels of IL-33 and ST2 were significantly different between AS patients and controls (p < 0.01) but not between active and inactive AS patients. CONCLUSIONS:Serum levels of IL-33 could partially reflect AS disease activity and indicate that IL-33/ST2 signalling plays an important role in the pathogenesis of AS.

journal_name

Scand J Rheumatol

journal_title

Scandinavian journal of rheumatology

authors

Li GX,Wang S,Duan ZH,Zeng Z,Pan FM

doi

10.3109/03009742.2012.735700

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

226-31

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

42

pub_type

杂志文章

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