Abstract:
:The occurrence of both multiple sclerosis (MS) and systemic lupus erythematosus (SLE) has previously been described in several members within the same family and in twins of successive generations, but the finding of both diseases in one patient is a great rarity. We here report on a rare coexistence of MS and SLE both in mother and daughter. Both patients fulfill the diagnostic criteria of primary-progressive subtype of MS as well as SLE. The finding constitutes supporting evidence of a common genetic background for these two autoimmune disorders.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Hietaharju A,Peltola J,Seppä J,Luukkainen R,Dastidar Pdoi
10.1080/03009740151095484keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
120-2issue
2eissn
0300-9742issn
1502-7732journal_volume
30pub_type
杂志文章abstract:OBJECTIVES:To study the link between metabolic syndrome (MetS), endothelial injury, and atherosclerosis in patients with systemic lupus erythematosus (SLE). METHODS:Consecutive SLE patients without a history of arterial thrombosis were screened for atherosclerosis at the carotid and coronary arteries by B-mode ultraso...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009740903046668
更新日期:2010-01-01 00:00:00
abstract::A radiological study of osteoarthrosis of the hips and knees has been performed in 364 female specialist physical education teachers, aged 46--60 years, who qualified between the years 1935 and 1950. The teachers were contacted by postal questionnaire and A.P. radiographs of the pelvis and knees were performed at a ho...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747909114633
更新日期:1979-01-01 00:00:00
abstract::Eight patients with a radiological diagnosis of Osteitis condensans ilii (OCI) had clinical features similar to those of 8 patients with sacro-iliitis (SI). The X-ray appearances may be very difficult to differentiate on standard films and discrimination between the two conditions has to be made from a combination of ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748509165498
更新日期:1985-01-01 00:00:00
abstract::Cytokines are signalling glycoproteins mediating acute inflammation, chronic inflammation, and connective tissue destruction. The present study was designed to characterize the profile of cytokine message in normal human articular cartilage and from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), by m...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097498441191
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Patients with rheumatoid arthritis (RA) have a high risk of cardiovascular disease (CVD). Recent national and international guidelines suggest strict treatment of CVD risk factors in RA. The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in patients with RA. METHOD...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2015.1028997
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of TNF blocking therapy on synovial immune activity in rat adjuvant arthritis (AA) by measuring mRNA expression of key macrophage and T cell cytokines during PEG sTNF-RI treatment (10mg/kg) on days 8, 10 and 12. METHODS:Paw volume was assessed every 3-4 days. Ankles were removed fo...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097402320318378
更新日期:2002-01-01 00:00:00
abstract::Vibrio vulnificus infection commonly presents as sepsis or wound infection. A case of alcoholic liver cirrhosis developed acute left heel pain and swelling 2 days after ingesting raw fish. Two sets of blood cultures indicated V. vulnificus. HLA-B27 was negative. Ultrasonography revealed left Achilles tendinitis. Fluid...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740701721769
更新日期:2008-05-01 00:00:00
abstract::Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnorma...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097400750041433
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To study the prevalence of comorbid conditions at diagnosis and during follow-up in a cohort of patients with early rheumatoid arthritis (RA) followed prospectively over 20 years, and to identify possible early predictive factors for future comorbidities. METHODS:A community-based cohort of 183 patients (me...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009741003674180
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To analyse the clinical features of Chinese undifferentiated spondyloarthritis (USpA) patients with predominantly axial involvement, and in particular the influence of human leucocyte antigen (HLA)-B27 and magnetic resonance imaging (MRI) of the sacroiliac joint (SIJ) on the classification of axial USpA. ME...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2011.585348
更新日期:2011-11-01 00:00:00
abstract::Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/03009749709065702
更新日期:1997-01-01 00:00:00
abstract::In a first stage the effect of a single dose of 3 g of salsalate on serum salicylate level was compared with a single intake of 3 g of soluble or enteric-coated acetylsalicylates in 12 healthy subjects. Salsalate seems to resorb faster than the enteric-coated forms but more slowly than the soluble forms of acetylsalic...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/03009748109095292
更新日期:1981-01-01 00:00:00
abstract::SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) is a new sulfhydryl compound having a relatively similar chemical structure to Tiopronin and D-penicillamine. An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and wit...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/03009748609092674
更新日期:1986-01-01 00:00:00
abstract::This population study includes the majority of all systemic lupus erythematosus (SLE) patients in Iceland (n = 65). The study lists various self-rated pain descriptions both from a 54-item pain questionnaire and from the somatisation section of the Diagnostic Interview Schedule (DIS). Results show SLE patients to have...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749309095104
更新日期:1993-01-01 00:00:00
abstract::Objective: Low molecular mass hyaluronan causes inflammatory processes and can act as a pro-inflammatory cytokine in skin and other sites of activity in psoriatic arthritis (PsA). This study investigated whether the molecular mass distribution of hyaluronan (HA) in skin and the quantity of circulating HA are related t...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1080/03009742.2019.1577490
更新日期:2019-07-01 00:00:00
abstract::Based on open studies. D-penicillamine (DPA) has been used for the treatment of systemic sclerosis (SSc) but we believe the controlled trial of this drug in SSc does not support its use to treat this disease. Open trials are inevitably biased by selection bias and randomized, blinded, controlled studies are required t...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.1080/030097401316909495
更新日期:2001-01-01 00:00:00
abstract::We have recently shown that synoviocytes and extracellular matrices exhibit distinct patterns of carbohydrate expression. Their biological relevance is however not known. The purpose of the present study was to find out whether human synovial tissue would also show a specific receptor pattern for complex sugar molecul...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749109096796
更新日期:1991-01-01 00:00:00
abstract::Preliminary studies indicate that plasma zinc concentrations, as estimated by atomic absorption spectrophotometry, are reduced in rheumatoid arthritis. A relationship has also been established between metacarpal index of osteoporosis and plasma zinc concentrations in rheumatoid subjects. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747509165264
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/03009742.2018.1464206
更新日期:2019-01-01 00:00:00
abstract::The effect of transcutaneous nerve stimulation (TNS) on joint pain was studied in patients with rheumatoid arthritis. Three different forms of TNS were used in an attempt to evaluate the influence of placebo effects. The results were evaluated by means of loading tests and from the patients' own assessments of pain re...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:To analyse the relative role of HLA-DR antigens in the susceptibility to, and clinical expression of psoriatic arthritis (PsA). PATIENTS AND METHODS:A retrospective cohort study of 120 patients with PsA who were assessed according to a standard protocol. Patients were classified in accordance with the predom...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740410005953
更新日期:2004-01-01 00:00:00
abstract::The relative value of nine spinal and thoracic mobility measurements was investigated in 73 male patients with ankylosing spondylitis (AS). The value of a test was obtained by the relative ranks of validity, reliability and sensitivity to change. Validity was determined as age-adjusted correlation of the test result w...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509099291
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. METHODS:Validated baseline and follow-up QoL questionnaires were completed by...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.1080/030097401317148516
更新日期:2001-01-01 00:00:00
abstract::The inflammatory cells in the minor salivary glands in situ in 11 patients with Sjögren's syndrome were characterized by using intracellular markers for T lymphocytes, plasma cells, mononuclear phagocytes and granulocytes. The methods used to demonstrate the markers were optimized histochemical and immunoperoxidase te...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748109095324
更新日期:1981-01-01 00:00:00
abstract::The immunoreactivity of the trophic peptide insulin-like growth factor I (IGF-I; somatomedin C) was mapped in nasal mucosa biopsies from three patients with Wegener's granulomatosis (WG) and one with idiopathic midline destructive disease (IMDD; idiopathic midline granuloma). Strongly increased IGF-I immuno-reactivity...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748909095410
更新日期:1989-01-01 00:00:00
abstract::Out of a total of 150 patients attending an out-patient clinic for anticoagulant therapy, 12 had disorders which normally would indicate a prolonged use of an antirheumatic drug. To 6 of these patients, naproxen (1/4 g twice daily) was given while anticoagulant treatment with phenprocoumon was continued in an unchange...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. METHOD:A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2013.786755
更新日期:2013-01-01 00:00:00
abstract::The coexistence of cryoglobulinemia and C4 deficiency was found in one family. Twelve subjects were examined, most of them being asymptomatic. Cryoglobulins were found in 9 members and its type was defined in 6 of them, 3 having mixed IgM-IgG and 3 having monoclonal IgM cryoglobulins. The concentration of the third co...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748409100379
更新日期:1984-01-01 00:00:00
abstract::Objective: The aim of this study was to review the literature to identify studies reporting repair of erosions in rheumatoid arthritis (RA).Method: A systematic literature search for publications on the repair of erosions was performed in PubMed and Embase, limited to human adults and published in English. Titles, abs...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2019.1606274
更新日期:2019-11-01 00:00:00
abstract::To determine the reliability of tender point assessment by manual palpation in patients with fibromyalgia, and to investigate the sources of variance, tender point scores by manual palpation were obtained in 30 fibromyalgia patients by 2 investigators; the assessments were repeated after 1 week. Test-retest stability ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509100882
更新日期:1995-01-01 00:00:00