Abstract:
:We have recently shown that synoviocytes and extracellular matrices exhibit distinct patterns of carbohydrate expression. Their biological relevance is however not known. The purpose of the present study was to find out whether human synovial tissue would also show a specific receptor pattern for complex sugar molecules. Endogenous lectins were displayed by means of biotinylated neoglycoproteins and sulfated polysaccharides in paraffin-embedded material or cryosections. In addition to certain carbohydrate components that are known to be constituents of the carbohydrate part of cellular glycoconjugates, our panel included heparin and fucoidan, a sulfated fucose. Binding sites were shown using the avidin-peroxidase technique for light microscopy. The results were compared with immunohistochemical methods and enzyme histochemistry. Our study demonstrates that human synovial tissue contains a complex pattern of endogenous lectins depending on the different types of synovitis. The staining method we used in the investigation allows for precise localization of saccharide binding receptors and is therefore believed to be a reliable technique for further phenotypic characterization of synovial cells.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Zschäbitz A,Gabius HJ,Stofft E,Reichel Wdoi
10.3109/03009749109096796subject
Has Abstractpub_date
1991-01-01 00:00:00pages
242-51issue
4eissn
0300-9742issn
1502-7732journal_volume
20pub_type
杂志文章abstract:OBJECTIVE:FURIN is a proprotein convertase enzyme that inhibits the proinflammatory function of T cells and myeloid cells. Elevated FURIN expression levels have been reported in immune-mediated diseases, such as primary Sjögren's syndrome. Here, we investigated the levels of FURIN in peripheral blood (PB) and synovial ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2018.1520294
更新日期:2019-05-01 00:00:00
abstract::Radiological examinations of the temporomandibular joints are not so often performed in patients with rheumatoid arthritis (RA). However, greater abnormalities of the mandibular head and neck may be evaluated at cervical radiography. With a new method, where the perpendicular distance from the palato-occipital line to...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748709102507
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the correlation between antiphosphatidylethanolamine antibodies (aPE) and some antiphospholipid antibodies (aPL)-related clinical manifestations in patients with systemic lupus erythematosus (SLE). METHODS:Patients with SLE (n=217) were tested for the presence of aPE, anticardiolipin antibodies (...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097401316909594
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a luciferase reporter gen...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2014.938113
更新日期:2015-05-01 00:00:00
abstract::Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnorma...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097400750041433
更新日期:2000-01-01 00:00:00
abstract::Objectives: To study associations between different anthropometric measures and incident gout, and to find the best predictive measure. Method: We used the baseline investigation from the Malmö Diet and Cancer study, excluding cases of prevalent gout (n = 28 081). Cox regression for each anthropometric measurement was...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2019.1583368
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Over the past few years researchers have suggested that vitamin D plays a diverse role in autoimmune diseases such as systemic lupus erythematosus (SLE). We sought to determine the prevalence and predictors of vitamin D deficiency in a cohort of non-supplemented female SLE patients from the Mediterranean reg...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.697189
更新日期:2012-01-01 00:00:00
abstract::Synovectomy of 20 wrist joints in 15 patients with juvenile chronic arthritis (JCA) was performed and results were evaluated 3 (0.5-5) years after surgery. The surgical procedure consisted of synovectomy of the radiocarpal joint, around the ulnar head and in all intercarpal joints. Resection of the ulnar head was not ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749009102534
更新日期:1990-01-01 00:00:00
abstract::Dorland's Illustrated Medical Dictionary gives the following definition of dactylitis (deltaalphachitauupsilonlambdaomicronsigma = digit): 'inflammation of a finger or toe'. Although any inflammatory process involving the fingers or toes may be called dactylitis, the term has entered in current use only in some well-d...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.1080/03009740600906677
更新日期:2006-09-01 00:00:00
abstract::In a hospital population of 154 patients with a wide range of inflammatory rheumatic diseases, patients with sicca symptoms were subjected to objective ocular and oral tests to establish cases with Sjögren's syndrome (SS). The plasma level of the leukocyte protein calprotectin has been shown to be a good indicator of ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749409103041
更新日期:1994-01-01 00:00:00
abstract::In biopsies from normal-looking skin, immune complexes in the dermo-epidermal junction zone were found by a direct immunofluorescence technique in 14 of 17 patients with systemic lupus erythematosus, in 6 of 12 patients with rheumatoid arthritis, but in none of 10 patients with temporal arteritis and 25 normal control...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747709095430
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:Our previous study identified rs559946, a human urate transporter 1 (hURAT1) single nucleotide polymorphism (SNP), as being significantly associated with risk of primary hyperuricaemia (HUA) in a Han Chinese population. In the current study we aimed to identify the genetic effects of rs559946 on gout suscept...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2013.808375
更新日期:2014-01-01 00:00:00
abstract::Reports of the rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults are reviewed in order to determine the most common presentations and which individuals are at risk for rheumatic disease. Relevant English-language articles were identified through a Medline search and from bibliographies...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.3109/03009749409103055
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of geographic variation on the risk of digital ulcer (DU) development in systemic sclerosis (SSc) patients. METHODS:This cross-sectional, multicentre study evaluated patients with SSc from centres located in different geographic regions of Brazil (subtropical and tropical climate zo...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/03009742.2016.1233994
更新日期:2017-07-01 00:00:00
abstract::Objective: Erosion healing in rheumatoid arthritis (RA) is difficult to demonstrate. This extension study aimed to determine whether 2 years of teriparatide (TPTD) produces erosion healing. Method: Subjects in a previous 12 month randomized controlled trial of TPTD in RA were invited to receive 12 additional months of...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1772362
更新日期:2021-01-01 00:00:00
abstract::In 1974-76 patients with early rheumatoid arthritis (duration less than or equal to 6 months) were investigated at the Institute for Rheumatism, Moscow, and at the Rheumatism Foundation Hospital, Heinola, Finland. Of 200 patients in each centre, 142 sex- and age-matched patients were chosen and followed up for one yea...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::A case of gold-induced enterocolitis in a 69-year-old female with rheumatoid arthritis who had received the new gold compound by oral administration (Auranofin (AF) for 4 weeks) is reported. Mild diarrhoea is a commonly described side effect accompanying AF, but in this case a severe colitis developed. The course of t...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309098544
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To study mortality from infections and accuracy of pre-mortem diagnoses in patients with rheumatoid arthritis (RA) autopsied during a 40-year period. METHODS:We investigated infectious causes of death, findings at autopsy, and clinicians' estimation of cause of death in 369 consecutively autopsied RA and 371...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740600556258
更新日期:2006-07-01 00:00:00
abstract::Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1774646
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:We sought to investigate the cost of living with rheumatoid arthritis (RA) and evaluate the influence of both demographics and specific disease characteristics on these costs. METHODS:We used a population-based questionnaire to survey 895 patients living in the city of Malmö, Sweden, during 2002. Data were o...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740601089580
更新日期:2007-05-01 00:00:00
abstract::We investigated the frequency of gut inflammation and the role of gut lesion in the pathogenesis of the ankylosing spondylitis (AS) in Korean patients. Ileocolonoscopy and biopsy of the colon and terminal ileum were performed on 24 Korean patients with AS. Endoscopic lesions were observed in 7 patients (29.2%). The le...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/03009749709065722
更新日期:1997-01-01 00:00:00
abstract::Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), ch...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749609080008
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:This study examined differences in reactions to disability between early and established rheumatoid arthritis (RA) patients, and whether these reactions were related to age, physical functioning, acceptance of illness, or self-efficacy. METHODS:Thirty-four patients with early RA (< 2 years since diagnosis) ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740310004685
更新日期:2004-01-01 00:00:00
abstract::Antibodies to soluble ribonucleoprotein (sRNP) are by definition a prerequisite for the diagnosis mixed connective tissue disease (MCTD). They are also found in 30--40% of other rheumatic conditions with a high titred speckled IFL reaction. The same is true for the most characteristic clinical features of MCTD, viz. R...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747809095661
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:There is evidence that fat tissue may influence the response to therapy in patients with arthritis. The aim of this study was to assess whether the body mass index (BMI) affects rates of clinical remission in patients with psoriatic arthritis (PsA) treated with anti-tumour necrosis factor (TNF)-α biological ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.715186
更新日期:2013-01-01 00:00:00
abstract::The effect of glycosaminoglycan polysulphate as medication for osteoarthritis was studied in an experimental model of osteoarthritis induced by periodic immobilization of rabbit knees. In a pilot experiment with 5 weeks of continuous immobilization there were indistinct differences between treated and control groups. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309098538
更新日期:1983-01-01 00:00:00
abstract::Psychological and emotional status was assessed in 36 patients with systemic lupus erythematosus (SLE) with the General Health Questionnaire-30 (GHQ-30) and Minnesota Multiphasic Personality Inventory (MMPI) questionnaires. The two tests were found to measure different aspects of psychological functioning. More than 5...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097498442226
更新日期:1998-01-01 00:00:00
abstract::A case of bilateral temporomandibular joint (TMJ) ankylosis in a Chinese male patient with ankylosing spondylitis is presented. A review of the literature emphasizes the rarity of this arthro-pathology in ankylosing spondylitis. The importance in the recognition of this complication by clinical examination supplemente...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749709115833
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Foot orthoses are commonly prescribed as an intervention for people with rheumatoid arthritis (RA). Data relating to the cost-effectiveness of foot orthoses in people with RA are limited. The aim was to evaluate the clinical and cost-effectiveness of two types of foot orthoses in people with established RA. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/03009742.2016.1196500
更新日期:2017-05-01 00:00:00
abstract::This population study includes the majority of all systemic lupus erythematosus (SLE) patients in Iceland (n = 65). The study lists various self-rated pain descriptions both from a 54-item pain questionnaire and from the somatisation section of the Diagnostic Interview Schedule (DIS). Results show SLE patients to have...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749309095104
更新日期:1993-01-01 00:00:00