Abstract：
OBJECTIVE:To study mortality from infections and accuracy of pre-mortem diagnoses in patients with rheumatoid arthritis (RA) autopsied during a 40-year period. METHODS:We investigated infectious causes of death, findings at autopsy, and clinicians' estimation of cause of death in 369 consecutively autopsied RA and 371 autopsied non-RA patients with same sex, age at death, and year of autopsy. We also compiled clinical features of RA patients from medical records available and examined the association between these and infectious causes of death. RESULTS:Deaths from any infection were more frequent in RA (36%) than in non-RA (26%) patients. In both groups, respiratory and urinary tract infections were the most common infectious causes of death. More RA patients died from urinary tract infections than non-RA patients. In approximately half of the patients in both groups, infection as a cause of death was unrecognized before death, with no major change occurring over the 40-year study period. CONCLUSIONS:Infections, especially respiratory and urinary tract infections, are frequent causes of death in RA patients. The high proportion of undiscovered infections as a cause of death highlights the diagnostic difficulty. With a decreasing number of autopsies being performed at present, greater numbers of infections may be under-reported.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Koivuniemi R,Leirisalo-Repo M,Suomalainen R,Piirainen H,Paimela Ldoi
10.1080/03009740600556258subject
Has Abstractpub_date
2006-07-01 00:00:00pages
273-6issue
4eissn
0300-9742issn
1502-7732pii
KLLK5R01M1083333journal_volume
35pub_type
杂志文章abstract：:Cogan's syndrome (CS) is a rare multisystemic disease characterized by vestibuloauditory dysfunction, inflammatory eye disease and vasculitis. Aortic aneurysms due to aortitis are under-recognized in CS, and are potentially fatal, with two of eight reported cases dying from aneurysm/arterial rupture. The presence of a...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740600907923
更新日期：2007-01-01 00:00:00
abstract：:Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498440877
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:To study the prevalence of comorbid conditions at diagnosis and during follow-up in a cohort of patients with early rheumatoid arthritis (RA) followed prospectively over 20 years, and to identify possible early predictive factors for future comorbidities. METHODS:A community-based cohort of 183 patients (me...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009741003674180
更新日期：2010-01-01 00:00:00
abstract：:Oxygen consumption was investigated during phagocytosis by leukocytes in patients suffering from rheumatoid arthritis, juvenile rheumatoid arthritis, dermatomyositis, systemic lupus erythematosus and scleroderma. Compared with the situation in normal persons, the mean oxygen consumption in the total patient group was ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747709095439
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients. METHOD:We used enzyme-linked immunosorbent assay (ELISA) to investigate the prevalence of EBV early antigen diffuse (EBV-EA/D) antibodies...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2012.665944
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:The present randomized controlled trial compared arthrocentesis of the effusive knee followed by corticosteroid injection performed by the conventional anatomic landmark palpation-guided technique to the same procedure performed with ultrasound (US) needle guidance. METHODS:Sixty-four palpably effusive knees...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.3109/03009742.2011.599071
更新日期：2012-02-01 00:00:00
abstract：:A patient with familial Pelger-Huet (PH) anomaly, which accompanied tuberculosis, and acute polyarthritis is described. Investigations surrounding this case suggests that the immunological abnormalities may be associated with the PH anomaly and the tuberculosis, and that the complications may be related to the develop...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749509095172
更新日期：1995-01-01 00:00:00
abstract：:The effect of transcutaneous nerve stimulation (TNS) on joint pain was studied in patients with rheumatoid arthritis. Three different forms of TNS were used in an attempt to evaluate the influence of placebo effects. The results were evaluated by means of loading tests and from the patients' own assessments of pain re...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1978-01-01 00:00:00
abstract：:The influence of one week's treatment with acetylsalicylic acid, ketoprofen, ketoprofen sustained-release capsules (Biovail capsules), and ketoprofen sustained-release tablets (IBP tablet) on gastrointestinal bleeding was investigated in 41 healthy male volunteers by means of a radiochromium assay. The physiological f...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/03009748309098550
更新日期：1983-01-01 00:00:00
abstract：:A total of 62 rheumatoid knee joints were treated with intra-articular 90Y. Results were assessed by clinical, roentgenologic and thermographic examination after a six-month follow-up. The majority of the joints had moderate roentgenologic manifestations of RA before treatment. The roentgenologic stage of the disease ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747509165443
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVES:To determine which variables at baseline are predictive for the development of rheumatoid arthritis (RA) from palindromic rheumatism (PR) in a Japanese population. METHODS:Anti-cyclic citrullinated peptide (anti-CCP) antibodies, joint involvement pattern, genotypes of HLA-DRB1, peptidylarginine deiminase (P...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009741003604534
更新日期：2010-08-01 00:00:00
abstract：:Primary cultures of neonatal dermal fibroblasts from two strains of mice (A/J and C57BL6/J) were utilized as an in vitro system to investigate the effects of glucocorticoids on cell growth and collagen synthesis. Protein and DNA synthesis were lower in untreated (control) A/J fibroblasts than in C57BL6/J fibroblasts. ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748309099741
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Aseptic loosening is one of the most important problems that can occur after total hip arthroplasty (THA). In this study, we analysed levels of large tenascin-C (TN-C) variants and compared them in pseudosynovial fluid from patients with aseptic loosening after THA with those in synovial fluid from patients u...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740510026733
更新日期：2005-11-01 00:00:00
abstract：:We have recently shown that synoviocytes and extracellular matrices exhibit distinct patterns of carbohydrate expression. Their biological relevance is however not known. The purpose of the present study was to find out whether human synovial tissue would also show a specific receptor pattern for complex sugar molecul...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749109096796
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2010.549837
更新日期：2011-01-01 00:00:00
abstract：:The effect of glycosaminoglycan polysulphate as medication for osteoarthritis was studied in an experimental model of osteoarthritis induced by periodic immobilization of rabbit knees. In a pilot experiment with 5 weeks of continuous immobilization there were indistinct differences between treated and control groups. ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748309098538
更新日期：1983-01-01 00:00:00
abstract：:Immobilization of a rabbit leg in extension results in the early development of an aseptic inflammation, synovial effusion and stiffening, and subsequent osteoarthritis of the knee. To study the pathogenesis of this experimental osteoarthritis, the hydrostatic pressures were measured in the knee, and distal metaphysis...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748809098756
更新日期：1988-01-01 00:00:00
abstract：:Rate of grip development (power), time to reach maximum grip strength and fatigue were not affected by the diurnal variation known to influence maximum grip strength and work during grip formation in normal subjects. Rheumatoid hands were less affected by exercise or temperature change of the forearm than were normal ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748209098173
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:To determine if calprotectin is predictive for outcome in patients with rheumatoid arthritis (RA). METHODS:Fifty six RA in-patients with variable disease duration were prospectively followed for five years. Clinical and laboratory data were collected to assess disease activity. Health Assessment Questionnair...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097402320817077
更新日期：2002-01-01 00:00:00
abstract：:Vibrio vulnificus infection commonly presents as sepsis or wound infection. A case of alcoholic liver cirrhosis developed acute left heel pain and swelling 2 days after ingesting raw fish. Two sets of blood cultures indicated V. vulnificus. HLA-B27 was negative. Ultrasonography revealed left Achilles tendinitis. Fluid...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740701721769
更新日期：2008-05-01 00:00:00
abstract：:Objective: Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease associated with psoriasis. Underlying genetic factors are considered important for disease expression and prognosis of PsA. Interleukin-1β-regulating protein complexes called inflammasomes are associated with several inflammatory diseases, e....
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2020.1834611
更新日期：2020-12-10 00:00:00
abstract：:We investigated the frequency of gut inflammation and the role of gut lesion in the pathogenesis of the ankylosing spondylitis (AS) in Korean patients. Ileocolonoscopy and biopsy of the colon and terminal ileum were performed on 24 Korean patients with AS. Endoscopic lesions were observed in 7 patients (29.2%). The le...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/03009749709065722
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVES:Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a luciferase reporter gen...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2014.938113
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVES:Giant cell arteritis (GCA) is a systemic disease with extensive vascular involvement. The aim of this study was to investigate the cumulative incidence of large vessel involvement (LVI) in GCA, the distribution of vessels involved, and predictors for LVI. METHOD:Patients with biopsy-proven GCA in a defined ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2016.1190984
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:The reproducibility of clinical tests for skin extensibility and consistency, essential for differentiating between types of Ehlers-Danlos syndrome (EDS) and benign joint hypermobility syndrome (BJHS), is unknown. Paraclinical methods may provide objective differential diagnostic methods. METHODS:Six EDS, 1...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740802520714
更新日期：2009-05-01 00:00:00
abstract：:Out of a total of 150 patients attending an out-patient clinic for anticoagulant therapy, 12 had disorders which normally would indicate a prolonged use of an antirheumatic drug. To 6 of these patients, naproxen (1/4 g twice daily) was given while anticoagulant treatment with phenprocoumon was continued in an unchange...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:In biopsies from normal-looking skin, immune complexes in the dermo-epidermal junction zone were found by a direct immunofluorescence technique in 14 of 17 patients with systemic lupus erythematosus, in 6 of 12 patients with rheumatoid arthritis, but in none of 10 patients with temporal arteritis and 25 normal control...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747709095430
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVES:Patients with rheumatoid arthritis (RA) have a high risk of cardiovascular disease (CVD). Recent national and international guidelines suggest strict treatment of CVD risk factors in RA. The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in patients with RA. METHOD...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1028997
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:This study examined differences in reactions to disability between early and established rheumatoid arthritis (RA) patients, and whether these reactions were related to age, physical functioning, acceptance of illness, or self-efficacy. METHODS:Thirty-four patients with early RA (< 2 years since diagnosis) ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740310004685
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:Cationic lipid complexes bind to angiogenic endothelial cells of solid tumours and microvessels of chronic inflammatory tissue. Methotrexate (MTX) is one of the drugs used in the therapy of rheumatoid arthritis (RA); it is applied systemically but can have serious side-effects. The aim of this study was to i...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1030448
更新日期：2015-01-01 00:00:00
