Epstein-Barr virus early antigen diffuse (EBV-EA/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients.

Abstract:

OBJECTIVE:We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients. METHOD:We used enzyme-linked immunosorbent assay (ELISA) to investigate the prevalence of EBV early antigen diffuse (EBV-EA/D) antibodies in sera from 60 patients with SLE, 40 with scleroderma (SSc), 20 with primary Sjögren's syndrome (pSS), 20 with rheumatoid arthritis (RA), 20 healthy controls, and also subjects with various circulating autoantibodies. Samples from patients were obtained from clinics specialized within the diseases in Denmark and Sweden and samples from healthy controls were obtained from volunteers. RESULTS:A significant elevated titre of immunoglobulin (Ig)A, IgG, and IgM EBV-EA/D antibodies was found in SLE patients compared to healthy controls, a finding not explained by immunosuppressive treatment or disease activity. The largest difference was observed for IgA EBV-EA/D antibodies (p = 0.0013) with a seropositive rate of 58% in SLE patients and 0% in healthy controls. RA and SSc patients and individuals seropositive for anti-Scl-70 were additionally found to have elevated titres of IgA EBV-EA/D antibodies (40%, p = 0.014; 60%, p = 0.015; and 38.5%, p = 0.045, respectively). However, the titres were generally lower than in SLE patients. CONCLUSION:Our findings support an association between EBV and SLE. The elevated titre of EBV-EA/D-directed IgA antibodies found in SLE patients could suggest reactivation of EBV in epithelial cells or reinfection of epithelial cells after reactivation in B cells, indicating lack of control of the latent infection.

journal_name

Scand J Rheumatol

authors

Draborg AH,Jørgensen JM,Müller H,Nielsen CT,Jacobsen S,Iversen LV,Theander E,Nielsen LP,Houen G,Duus K

doi

10.3109/03009742.2012.665944

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

280-9

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

41

pub_type

杂志文章
  • Involvement of the lateral atlanto-axial joints as first and late symptom of rheumatoid arthritis.

    abstract::Thirty cases of unilateral or bilateral atlanto-axial arthritis are described. They were found among 606 RA patients. According to the degree of involvement, the 30 cases were divided into four groups: A. 16 cases. B. 5 cases. C. 7 cases. D. 2 cases. In two patients the atlanto-axial arthritis was the primary lesion. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165372

    authors: Kerckhove HV

    更新日期:1987-01-01 00:00:00

  • Enhanced breakdown of bovine articular cartilage proteoglycans by conditioned synovial medium. The effect of serum and dextran sulphate.

    abstract::Medium from cultured bovine synovial membrane when applied to articular cartilage from the same animal enhanced proteoglycan breakdown, as measured by the release of [35S]sulphate from prelabelled cartilage, principally by activating chondrocytes to secrete or activate their own enzymes. This effect persisted whether ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748209098113

    authors: Jones IL,Klämfeldt A,McGuire MB

    更新日期:1982-01-01 00:00:00

  • Prevalence and significance of MEFV gene mutations in patients with sarcoidosis.

    abstract:OBJECTIVES:Sarcoidosis is a chronic granulomatous disease. Pyrin has anti-inflammatory activity in the regulation of inflammasomes and is encoded by the Mediterranean fever (MEFV) gene. MEFV gene mutations trigger the inflammatory cascade and cause familial Mediterranean fever (FMF). A relationship between various rheu...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1092580

    authors: Sever F,Kobak S,Goksel Ö,Goksel T,Orman M,Berdeli A

    更新日期:2016-01-01 00:00:00

  • Plant thorn synovitis diagnosed by magnetic resonance imaging.

    abstract::Plant thorn synovitis is an overlooked cause of monoarthritis, with difficulties in diagnosis and treatment (1). We report on a case of thorn induced synovitis, not confirmed by histopathology, but strongly suspected by magnetic resonance imaging (MRI), that visualizes the foreign body (first case reported). ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749409103051

    authors: Maillot F,Goupille P,Valat JP

    更新日期:1994-01-01 00:00:00

  • Prevalence of interstitial lung involvement in patients with connective tissue diseases assessed with high-resolution computed tomography.

    abstract:OBJECTIVES:To assess the prevalence of interstitial lung disease (ILD) in patients with different forms of connective tissue disease (CTD) using non-invasive procedures including high-resolution computed tomography (HRCT) and to evaluate the relationship between the imaging and functional status of the patients. METHO...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1080/03009740600844381

    authors: Afeltra A,Zennaro D,Garzia P,Gigante A,Vadacca M,Ruggiero A,Dardes N,Navajas MF,Zobel BB,Amoroso A

    更新日期:2006-09-01 00:00:00

  • Cervical myelopathy in psoriatic spondylitis.

    abstract::In psoriatic spondylitis, the complication of cervical cord compression with myelopathy is rare. We present a case of psoriatic spondylitis causing cervical myelopathy which required surgical intervention, and review the literature of reported neurological complications in psoriatic spondylitis. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749609104069

    authors: Akagi S,Saito T,Kato I,Ogawa R

    更新日期:1996-01-01 00:00:00

  • The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome.

    abstract:OBJECTIVE:To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production. METHODS:We genotyped 111 unrelated German Caucasian patients with pSS and...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740801910353

    authors: Willeke P,Gaubitz M,Schotte H,Becker H,Domschke W,Schlüter B

    更新日期:2008-07-01 00:00:00

  • The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.

    abstract::YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthriti...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950154257

    authors: Volck B,Ostergaard K,Johansen JS,Garbarsch C,Price PA

    更新日期:1999-01-01 00:00:00

  • Exercises may be as efficient as subacromial decompression in patients with subacromial stage II impingement: 4-8-years' follow-up in a prospective, randomized study.

    abstract:OBJECTIVES:To compare the prognosis of subacromial impingement (SAI) stage II treated conservatively or with subacromial decompression. METHODS:A follow-up study after 4-8 years in a randomized controlled trial (RCT) with 90 adult cases with SAI treated in a Danish hospital from 1996 to 2000 with graded physiotherapy ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009740600556167

    authors: Haahr JP,Andersen JH

    更新日期:2006-05-01 00:00:00

  • IgM, IgG and IgA rheumatoid factors (antiglobulins) in early rheumatoid arthritis and their production of articular index over one year.

    abstract::An enzyme-linked immunosorbent assay was used to detect antiglobulins (rheumatoid factors, RF) of various classes in 33 patients with recently diagnosed rheumatoid arthritis and to follow their progress with 3-monthly checks for 1 year. For RF, IgA-RF and IgM-RF showed greater sensitivity than the latex test, either o...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709165411

    authors: March RE,Kirwan JR,Reeback JS,Holborow EJ

    更新日期:1987-01-01 00:00:00

  • Perinatal outcome in pregnancies of women with connective tissue disease and inflammatory rheumatic disease in Norway.

    abstract::Perinatal outcome in infants of women with rheumatic disease notified between 1967 95 to the Medical Birth Registry of Norway was compared to women without such disease. Logistic regression provided odds ratios for associations between rheumatic disease and perinatal outcome for 3 time periods: 1967-76, 1977-86, and 1...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950155337

    authors: Skomsvoll JF,Ostensen M,Irgens LM,Baste V

    更新日期:1999-01-01 00:00:00

  • Antinuclear antibody screening in this new millennium: farewell to the microscope?

    abstract::ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime,...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162860

    authors: Nossent H,Rekvig OP

    更新日期:2001-01-01 00:00:00

  • The relative value of spinal and thoracic mobility measurements in ankylosing spondylitis.

    abstract::The relative value of nine spinal and thoracic mobility measurements was investigated in 73 male patients with ankylosing spondylitis (AS). The value of a test was obtained by the relative ranks of validity, reliability and sensitivity to change. Validity was determined as age-adjusted correlation of the test result w...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749509099291

    authors: Viitanen JV,Kautiainen H,Suni J,Kokko ML,Lehtinen K

    更新日期:1995-01-01 00:00:00

  • The effect of fasting on plasma cyclic adenosine-3', 5'-monophosphate in rheumatoid arthritis.

    abstract::Cyclic adenosine-3', 5'-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment du...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112353

    authors: Trang LE,Lövgren O,Bendz R,Mjös O

    更新日期:1980-01-01 00:00:00

  • Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.

    abstract:OBJECTIVES:The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. METHOD:A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2013.786755

    authors: Qiu R,Zhang H,Zhao H,Li J,Guo C,Gong Y,Liu Q

    更新日期:2013-01-01 00:00:00

  • Group II phospholipase A2 in synovial fluid and serum in acute arthritis.

    abstract::Increased catalytic activity of synovial-type (group II) phospholipase A2 (syn-PLA2), has been associated with cartilage erosions in rheumatoid arthritis and osteoarthritis. The catalytic activity of phospholipase A2 and the concentration of syn-PLA2 were measured in a prospective study in synovial fluid (SF) samples ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749409103030

    authors: Kortekangas P,Aro HT,Nevalainen TJ

    更新日期:1994-01-01 00:00:00

  • Enthesitis of proximal insertion of the deltoid in the course of seronegative spondyloarthritis. An atypical enthesitis that can mime impingement syndrome.

    abstract:OBJECTIVE:To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics. METHODS:A retrospective study of clinical, sonographic and radiological examinations of the shoulders of 100 ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:

    authors: Falsetti P,Frediani B,Filippou G,Acciai C,Baldi F,Storri L,Bisogno S,Marcolongo R

    更新日期:2002-01-01 00:00:00

  • Prevalence of spondyloarthropathies in an Italian population sample: a regional community-based study.

    abstract:OBJECTIVE:To estimate the prevalence of spondyloarthropathies (SpA) in an adult population in Marche, a region located in central Italy. METHODS:A cross-sectional population-based study was conducted on a target adult population of 20 882. Questionnaires were sent to a random sample of 3664 individuals aged 18 years a...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740600904243

    authors: De Angelis R,Salaffi F,Grassi W

    更新日期:2007-01-01 00:00:00

  • Immunoperoxidase assay for anti-dsDNA antibodies using Crithidia luciliae substrates.

    abstract::In studies on 779 fresh, unselected ANA+ sera, 50 (6.4%) were found to have anti-dsDNA antibodies, by using CIP (C. luciliae immunoperoxidase), and 84% of the 50 patients met the criteria for definite SLE. After freezing 36 of these sera for 13 +/- 1 months, only 52.8% were again positive by CIP. Using CIF (C. lucilia...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748509102043

    authors: Lee TK,Rothberger H

    更新日期:1985-01-01 00:00:00

  • Anti-cardiolipin antibodies, Raynaud's phenomenon with digital ischemia, and non small cell carcinoma of the lung.

    abstract::Raynaud's phenomenon, digital ischemia, antinuclear antibodies and anticardiolipin antibodies are uncommon features of malignancy. The association of all of these in a patient with malignancy has not previously been reported. We describe a 52 year old woman with non small-cell carcinoma of the lung who also had Raynau...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162978

    authors: Vaidya S,Logan JW

    更新日期:2001-01-01 00:00:00

  • Activation of the coagulation system in connective tissue diseases. A study of [125I] fibrinogen clearance.

    abstract::Fifty-one patients with different connective tissue diseases in either active or clinically inactive phase were studied to detect the incidence of chronic or subclinical consumption coagulopathy in these forms. Every patient received intravenously 20 mu Ci of [125I] fibrinogen and the clearance of the labeled fibrinog...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112361

    authors: Canesi BA,Banfi F,Rossi AF,Sinigaglia L

    更新日期:1980-01-01 00:00:00

  • Ileocolonoscopic and histologic studies of Korean patients with ankylosing spondylitis.

    abstract::We investigated the frequency of gut inflammation and the role of gut lesion in the pathogenesis of the ankylosing spondylitis (AS) in Korean patients. Ileocolonoscopy and biopsy of the colon and terminal ileum were performed on 24 Korean patients with AS. Endoscopic lesions were observed in 7 patients (29.2%). The le...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009749709065722

    authors: Lee YH,Ji JD,Kim JS,Bak YT,Lee CH,Kim CH,Chae YS,Song GG

    更新日期:1997-01-01 00:00:00

  • Immunoprecipitates used as a reagent for rheumatoid factors.

    abstract::IgM and IgG rheumatoid factors (RFs) were purified by affinity chromatography and gel filtration. The preparations thus obtained were used as standards in a radio-immunoassay for RF detection. In this assay, RFs were reacted with immunoprecipitates, and the RFs were detected with radiolabelled (F(ab')2 fragments speci...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748409100395

    authors: Nordfang O,Høier-Madsen M,Danielsen A

    更新日期:1984-01-01 00:00:00

  • X-ray diffraction analysis of spontaneously draining calcinosis in scleroderma patients.

    abstract:OBJECTIVES:Calcium hydroxyapatite (HA) is reported to be the major constituent of soft tissue calcinosis in patients with scleroderma (systemic sclerosis, SSc). Mechanical stress and local tissue hypoxia are thought to be important in the pathogenesis of SSc calcinosis. We sought to analyse spontaneously draining mater...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2016.1219766

    authors: Hsu VM,Emge T,Schlesinger N

    更新日期:2017-03-01 00:00:00

  • The safety profile of low-dose cladribine in refractory rheumatoid arthritis. A pilot trial.

    abstract::Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.3109/03009749709065702

    authors: Schirmer M,Mur E,Pfeiffer KP,Thaler J,Konwalinka G

    更新日期:1997-01-01 00:00:00

  • Serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and systemic idiopathic vasculitis.

    abstract::Soluble interleukin 2 receptor (sIL2R) may be used as an index of immune perturbation. We report on the correlation between the serum levels of sIL2R, as assessed with a sandwich-ELISA, and disease activity in 61 patients with Systemic Lupus Erythematosus (SLE) and in 15 with systemic idiopathic vasculitis (SIV). The ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749309095125

    authors: Danieli MG,Paoletti P,Recchioni A,Gabrielli A,Danieli G

    更新日期:1993-01-01 00:00:00

  • The effect of multimeric adiponectin isoforms and leptin on the function of rheumatoid fibroblast-like synoviocytes.

    abstract:OBJECTIVES:To evaluate the effects of physiologically relevant concentrations of multimeric adiponectin isoforms and leptin on the function of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). METHOD:FLS, isolated from the synovial tissue of 21 RA patients, were stimulated for 24 h with ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1025833

    authors: Kontny E,Janicka I,Skalska U,Maśliński W

    更新日期:2015-01-01 00:00:00

  • Effects of osmium tetroxide on the rabbit knee joint normal synovial membrane.

    abstract::The effect of osmium tetroxide, which is used in treatment of rheumatoid arthritis, was histologically and electronmicroscopically examined in the normal synovial membrane of the rabbit. The animals were albino rabbits, and they were 20 altogether. 0.3 ml. of 1% OsO(4) solution was injected, i.a., in the right knee. T...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165362

    authors: Möttönen M,Pantio M,Nevalainen T

    更新日期:1987-01-01 00:00:00

  • Relationship of cell growth to collagen synthesis in glucocorticoid treated A/J and C57BL6/J neonatal mouse dermal fibroblasts.

    abstract::Primary cultures of neonatal dermal fibroblasts from two strains of mice (A/J and C57BL6/J) were utilized as an in vitro system to investigate the effects of glucocorticoids on cell growth and collagen synthesis. Protein and DNA synthesis were lower in untreated (control) A/J fibroblasts than in C57BL6/J fibroblasts. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748309099741

    authors: Verbruggen LA,Orloff S,Rao VH,Salomon DS

    更新日期:1983-01-01 00:00:00

  • The value of the diagnostic criteria in rheumatoid arthritis.

    abstract::The ARA and the New York diagnostic criteria for rheumatoid arthritis were studied in 411 patients with a recent inflammatory joint disease (100 with RA, 311 with other disease) in order to evaluate their value in distinguishing progressive rheumatoid arthritis from other joint diseases. Rheumatoid factor, symmetrical...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748309102003

    authors: Kaarela K,Hämeenkorpi R,Isomäki H

    更新日期:1983-01-01 00:00:00