Abstract:
OBJECTIVES:To evaluate the effects of physiologically relevant concentrations of multimeric adiponectin isoforms and leptin on the function of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). METHOD:FLS, isolated from the synovial tissue of 21 RA patients, were stimulated for 24 h with interleukin (IL)-1β (1 ng/mL) and adiponectin isoforms [fraction enriched with high-molecular-weight (HMW) oligomers and middle-molecular-weight (MMW) hexamers or low-molecular-weight (LMW) trimers, 10 μg/mL each], or leptin (10 ng/mL), either separately or in a combination of IL-1β and the respective adipokine. Moreover, cells were pre-treated for 24 h with adipokines, then stimulated for 8 h with IL-1β. The concentrations of IL-6, IL-8, matrix metalloproteinase (MMP)-3, and dickkopf (DKK)-1, an inhibitor of osteoblastogenesis, in culture supernatants, as well as the concentrations of leptin, HMW, MMW, and LMW adiponectin in sera and synovial fluid (SF) samples, were measured by specific enzyme-linked immunosorbent assays (ELISAs). RESULTS:In comparison with sera, SF samples contained similar amounts of leptin, lower amounts of total adiponectin but a higher proportion of the LMW isoform. Separately added IL-1β and HMW/MMW adiponectin, but not LMW adiponectin or leptin, up-regulated the release of IL-6, IL-8, and MMP-3 from FLS but no synergy was observed in co-stimulation experiments. However, pre-treatment of FLS with HMW/MMW or LMW significantly raised the IL-1β-triggered secretion of MMP-3 and IL-6 or MMP-3, respectively. CONCLUSIONS:Adiponectin not only triggers pro-inflammatory and pro-destructive activities of rheumatoid FLS but also pre-disposes these cells to a stronger response to IL-1β. Thus, it is likely that adiponectin is more important in the initiation phase than in the chronic phase of RA.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Kontny E,Janicka I,Skalska U,Maśliński Wdoi
10.3109/03009742.2015.1025833subject
Has Abstractpub_date
2015-01-01 00:00:00pages
363-8issue
5eissn
0300-9742issn
1502-7732journal_volume
44pub_type
杂志文章abstract::The prevalence of rheumatoid arthritis in 1,287 persons living in densely populated areas and 1, 287 persons living in thinly populated areas, matched as to sex, age, occupation and geographical area, was compared. The patient material was obtained in an epidemiological survey of rheumatoid arthritis (ARA definition) ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747009165351
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics. METHODS:A retrospective study of clinical, sonographic and radiological examinations of the shoulders of 100 ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The objective was to prospectively evaluate the short as well as the long-term effects of intensive physiotherapy in a stable, sunny and warm climate on physical function and health related quality of life in patients with rheumatoid arthritis (RA) and spondylarthropathies (SpA). METHODS:Ninety-three Swedish...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.1080/03009740310000120
更新日期:2003-01-01 00:00:00
abstract::Rate of grip development (power), time to reach maximum grip strength and fatigue were not affected by the diurnal variation known to influence maximum grip strength and work during grip formation in normal subjects. Rheumatoid hands were less affected by exercise or temperature change of the forearm than were normal ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748209098173
更新日期:1982-01-01 00:00:00
abstract::Objectives: Low body weight is an easily assessable cause of Raynaud's phenomenon (RP), and is frequently overlooked by clinicians. We aim to investigate the association of low body weight (body mass index < 18.5 kg/m2), involuntary weight loss, and nutritional restrictions with the presence of RP. Method: Participant...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1780310
更新日期:2020-10-16 00:00:00
abstract:OBJECTIVE:To establish by ultrasonography (US) the frequency of calcaneal entheses involvement in erosive osteoarthritis (EOA), nodal osteoarthritis (NOA), RA and PsA, and to compare these results in order to aid clinicians in the differential diagnosis among these diseases. A comparison between US results and radiogra...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740310003721
更新日期:2003-01-01 00:00:00
abstract::Objective: Vasculopathy in systemic sclerosis (SSc) is characterized by the obliteration of arterioles and a reduced capillary density in various tissues. In SSc, atrophic alterations of the choroid have been suggested based on morphological data acquired by optical coherence tomography (OCT). In this study, we aimed ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2019.1641616
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2010.549837
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The diagnosis of Achilles and patella tendinitis has until recently been based on clinical examination, and treatment with local steroid injection has been given blindly. This is the first randomized, double blind, placebo-controlled study of local steroid injection in athletes with chronic tendinitis, which...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/03009740310004126
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To analyse the clinical features of Chinese undifferentiated spondyloarthritis (USpA) patients with predominantly axial involvement, and in particular the influence of human leucocyte antigen (HLA)-B27 and magnetic resonance imaging (MRI) of the sacroiliac joint (SIJ) on the classification of axial USpA. ME...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2011.585348
更新日期:2011-11-01 00:00:00
abstract::Shoulder muscle performance was tested in 8 working ankylosing spondylitis (AS) patients and compared with 10 healthy male referents. The AS patients were all in a non-active state and had no shoulder symptoms. Electromyographic fatigue development in the descending part of the trapezius muscle was significantly faste...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748709165269
更新日期:1987-01-01 00:00:00
abstract::A case of bilateral temporomandibular joint (TMJ) ankylosis in a Chinese male patient with ankylosing spondylitis is presented. A review of the literature emphasizes the rarity of this arthro-pathology in ankylosing spondylitis. The importance in the recognition of this complication by clinical examination supplemente...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749709115833
更新日期:1997-01-01 00:00:00
abstract::Fc-receptors for IgG (Fc gamma R) are important triggers of effector function in macrophages. We have investigated the distribution of cells bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in 14 synovia and 3 nodules from rheumatoid arthritis (RA) patients, using monoclonal antibodies on serial cryostat sectio...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749009102116
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Calcium hydroxyapatite (HA) is reported to be the major constituent of soft tissue calcinosis in patients with scleroderma (systemic sclerosis, SSc). Mechanical stress and local tissue hypoxia are thought to be important in the pathogenesis of SSc calcinosis. We sought to analyse spontaneously draining mater...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2016.1219766
更新日期:2017-03-01 00:00:00
abstract::The aim of this study was to evaluate the presence of PAF-acether (PAF), its specific degrading enzyme acetylhydrolase, and tumor necrosis factor (TNF) concentrations in blood and synovial fluid (SF) from patients with active RA. The variations of the mediators were also evaluated after corticosteroid perfusions in 7 ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509099308
更新日期:1995-01-01 00:00:00
abstract::The initial evaluation of 25 patients suspected of suffering from Sjögren's syndrome (SS) disclosed that sialopenia and glandular atrophy without focal sialo-adenitis was the second most common cause, after SS itself, of patient complaints. This emphasizes the importance of conclusive diagnostic criteria to prevent ov...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/03009748809098766
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:A proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are B-cell stimulation and survival molecules. We have investigated whether APRIL and/or BAFF activity is enhanced in the systemic and/or intrathechal compartment of patients with neuropsychiatric systemic lupus erythematosus (NPSLE)...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2010.550900
更新日期:2011-01-01 00:00:00
abstract::This paper reports the effects of peroral administration of the two non-steroid anti-inflammatory drugs ibuprofen and flubiprofen on orthotopic and induced heterotopic bone. The treatment induced no effects on the mineral or hydroxyproline contents of femur compared with a control group. Nor could any generalized toxi...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309102907
更新日期:1983-01-01 00:00:00
abstract::The aim of the present study was to assess the T cell cytokines IFN-gamma, IL-2, IL-4 and IL-5 in labial salivary glands (LSG) in Sjögren's syndrome (SS) and healthy controls using RT-PCR and immunohistochemistry. IFN-gamma is always or almost always produced in SS and in healthy controls. IL-2 was also found in some ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097499442577
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:There is evidence that fat tissue may influence the response to therapy in patients with arthritis. The aim of this study was to assess whether the body mass index (BMI) affects rates of clinical remission in patients with psoriatic arthritis (PsA) treated with anti-tumour necrosis factor (TNF)-α biological ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.715186
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Platelets are thought to participate in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthritis (RA). We showed recently an in vivo increase in platelet-endothelial cell interactions in mice with antigen-induced arthritis (AiA). The underlying mechanisms are not yet clear. The aim of th...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740701218741
更新日期:2007-07-01 00:00:00
abstract::Objective: Pain is a common and distressing feature of juvenile idiopathic arthritis (JIA). Pain interference (PI) is underexplored in long-term conditions such as JIA. The aim of this study was to explore the factors associated with PI in young adults with JIA. Methods: All consecutive JIA patients aged 18-30 years i...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/03009742.2019.1596308
更新日期:2019-09-01 00:00:00
abstract::Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748909102104
更新日期:1989-01-01 00:00:00
abstract::The IgG subclass distribution of anti-RNP antibodies was determined in sera from 34 patients. The antibodies were mainly of the complement-fixing IgG1 subclass with minor contributions of IgG3 and IgG4 antibodies. Selected sera contained IgG2 (non-complement fixing) anti-RNP antibodies and may possibly identify a subg...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748609092672
更新日期:1986-01-01 00:00:00
abstract::Three dissertations on arthritis in Latin by the Englishman William Musgrave have been reviewed to find possible descriptions of rheumatoid arthritis. Polyarticular long-lasting joint pain in women are the cases most probable to be rheumatoid arthritis. This was found in 18 of 150 case stories. In the general sections...
journal_title:Scandinavian journal of rheumatology
pub_type: 传,历史文章,杂志文章
doi:10.3109/03009749509095162
更新日期:1995-01-01 00:00:00
abstract::Objectives: The study aimed to evaluate the feasibility of a blood flow restriction (BFR) training regimen in patients with rheumatoid arthritis (RA); and to compare the effects of 4 weeks of BFR training with low-intensity strength training on muscle strength, muscle endurance, and joint pain in patients with RA. Met...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1829701
更新日期:2020-12-10 00:00:00
abstract::In an effort to clarify factors related to the pathogenesis of experimental osteoarthritis, biochemical alterations were studied in articular soft tissues of adult rabbits through the immobilization of the knee of the hind leg in extension for 3, 7, 11, 18, 35 or 56 days. The medial collateral ligament and medial meni...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748409100374
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. METHODS:WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients start...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2016.1231338
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Juvenile idiopathic arthritis (JIA) frequently causes temporomandibular joint (TMJ) inflammation. The aim of this study was to evaluate the presence of orofacial pain and temporomandibular dysfunction in patients with JIA and controls. METHODS. Forty-one patients with JIA and 41 age- and sex-matched healthy ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.675585
更新日期:2012-10-01 00:00:00
abstract::The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovi...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509095146
更新日期:1995-01-01 00:00:00