Group II phospholipase A2 in synovial fluid and serum in acute arthritis.

Abstract:

:Increased catalytic activity of synovial-type (group II) phospholipase A2 (syn-PLA2), has been associated with cartilage erosions in rheumatoid arthritis and osteoarthritis. The catalytic activity of phospholipase A2 and the concentration of syn-PLA2 were measured in a prospective study in synovial fluid (SF) samples from 66 patients with acute knee joint effusion. The median (range) of the concentration of syn-PLA2 in SF was 210 micrograms/l (80-1480 micrograms/l) in culture-positive septic arthritis, 460 micrograms/l (270-1040 micrograms/l) in reactive arthritis, 780 micrograms/l (120-2710 micrograms/l) in osteoarthritis and 230 micrograms/l (80-1400 micrograms/l) in traumatic joint effusions. High concentrations of syn-PLA2 are found also in SF of patients with arthritides not expected to lead to permanent destruction of cartilage.

journal_name

Scand J Rheumatol

authors

Kortekangas P,Aro HT,Nevalainen TJ

doi

10.3109/03009749409103030

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

68-72

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

23

pub_type

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