Abstract:
:ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime, many of the nuclear and cytoplasmatic auto-antigens, related to specific types of autoimmune disease, have been characterised and can be tested for in specific ELISA assays (E-ANA). These assays are in large part automated and enable the large volume testing required, by the current attitude, to use ANA-testing for its high negative predictive value in the exclusion of systemic autoimmune disease. In addition, E-ANA assays give specific results for clinically relevant autoantibodies, while its test repertoire can be altered at any given time to reflect changes in current thinking on relevant auto-antigens. Thus, we suggest that the unspecific F-ANA test should no longer be considered the gold standard for the detection of clinically relevant autoantibodies.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Nossent H,Rekvig OPdoi
10.1080/030097401300162860keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
123-6; discussion 127-8issue
3eissn
0300-9742issn
1502-7732journal_volume
30pub_type
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journal_title:Scandinavian journal of rheumatology
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journal_title:Scandinavian journal of rheumatology
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journal_title:Scandinavian journal of rheumatology
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doi:10.3109/03009749209099229
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abstract:OBJECTIVE:We sought to investigate the cost of living with rheumatoid arthritis (RA) and evaluate the influence of both demographics and specific disease characteristics on these costs. METHODS:We used a population-based questionnaire to survey 895 patients living in the city of Malmö, Sweden, during 2002. Data were o...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740601089580
更新日期:2007-05-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748609102075
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doi:10.1080/030097498440877
更新日期:1998-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740600907923
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/03009740802629424
更新日期:2009-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097402760375197
更新日期:2002-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740701721769
更新日期:2008-05-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749009095047
更新日期:1990-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309099741
更新日期:1983-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749609104069
更新日期:1996-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748809098805
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/03009740701218741
更新日期:2007-07-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747909114633
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009740903002257
更新日期:2009-11-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
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doi:10.3109/03009748209098173
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509099308
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/03009740902911664
更新日期:2009-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-05-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 社论,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1764617
更新日期:2021-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097498442406
更新日期:1998-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748209098172
更新日期:1982-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/03009742.2016.1196500
更新日期:2017-05-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009740903270623
更新日期:2010-03-01 00:00:00