Effects of a PEGylated soluble TNF receptor type 1 (PEG sTNF-RI) on cytokine expression in adjuvant arthritis.

Abstract:

OBJECTIVE:To investigate the effects of TNF blocking therapy on synovial immune activity in rat adjuvant arthritis (AA) by measuring mRNA expression of key macrophage and T cell cytokines during PEG sTNF-RI treatment (10mg/kg) on days 8, 10 and 12. METHODS:Paw volume was assessed every 3-4 days. Ankles were removed for quantitative radiology and histology and synovial membrane removed to determine cytokine mRNA expression using semi-quantitative RT-PCR. T cells in joints were quantified by immunohistochemistry. RESULTS:Paw volume was significantly decreased in rats treated with PEG STNF-RI from days 12 to 17. Histology scores and synovial T cell numbers were reduced on days 13 and 17 and radiology scores significantly reduced on day 13. Expression of synovial TNF, IFN-gamma, IL-17, IL-2 and IL-4 mRNA was unchanged in treated rats and TGF-beta expression was significantly increased at day 13. CONCLUSIONS:PEG sTNF-RI attenuates AA and disease recurs after treatment ceases, similar to human rheumatoid arthritis. Continued TNF production and/or ongoing T cell activity, may explain the recrudescence of disease once treatment is stopped.

journal_name

Scand J Rheumatol

authors

Bush KA,Walker JS,Frazier J,Kirkham BW

doi

10.1080/030097402320318378

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

198-204

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

31

pub_type

杂志文章
  • C3 activation products, C3 containing immune complexes, the terminal complement complex and native C9 in patients with rheumatoid arthritis.

    abstract::Complement activation products, C9 and C3-containing circulating immune complexes (CIC), were evaluated in plasma and synovial fluid (SF) from patients with rheumatoid arthritis (RA) and osteoarthritis. C3 activation products and the fluid phase terminal complement complex were considerably elevated in SF from RA pati...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749109103019

    authors: Olmez U,Garred P,Mollnes TE,Harboe M,Berntzen HB,Munthe E

    更新日期:1991-01-01 00:00:00

  • Cystatin C concentration is correlated with disease activity in rheumatoid arthritis patients.

    abstract:OBJECTIVES:Rheumatoid arthritis (RA) is a systemic, inflammatory disease. Renal involvement worsens the course of RA and increases mortality. It is suggested that chronic inflammatory processes may contribute to renal impairment. The aim of this study was to investigate the impact of chronic inflammation and RA activit...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2011.571219

    authors: Targońska-Stepniak B,Majdan M

    更新日期:2011-01-01 00:00:00

  • Gustatory and olfactory function in rheumatoid arthritis.

    abstract:OBJECTIVES:To evaluate the gustatory and olfactory functions of patients with rheumatoid arthritis (RA) compared to sex- and age-matched healthy subjects and to investigate a potential relationship between disease activity [using the 28-joint Disease Activity Score (DAS28)] and chemosensory capacity. Furthermore, to di...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2010.517547

    authors: Steinbach S,Proft F,Schulze-Koops H,Hundt W,Heinrich P,Schulz S,Gruenke M

    更新日期:2011-05-01 00:00:00

  • Decrease of proteinuria in a patient with adult-onset Still's disease and glomerulonephritis after anti-TNFalpha therapy.

    abstract::We report the case of a 41-year-old man diagnosed with Still's disease. Multiple disease-modifying anti-rheumatic drug (DMARD) therapies failed to induce disease remission or to prevent progressive joint destruction. The man presented with active arthritis and classical Still's rash accompanied by fever. Anti-tumour n...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740600844688

    authors: Thonhofer R,Soleiman A,Kriessmayr M,Thonhofer U,Wipfler E,Gaugg M,Eder S,Erlacher L

    更新日期:2006-11-01 00:00:00

  • Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.

    abstract::No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097402317255372

    authors: Mayordomo L,Marenco JL,Gomez-Mateos J,Rejon E

    更新日期:2002-01-01 00:00:00

  • Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study.

    abstract::Objective: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease. Studies suggest that pro-inflammatory cytokines may be attenuated by the vagus nerve through the cholinergic anti-inflammatory pathway. We aimed to evaluate the anti-inflammatory effects of short-term transcutaneous non-invasive vagus...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1764617

    authors: Drewes AM,Brock C,Rasmussen SE,Møller HJ,Brock B,Deleuran BW,Farmer AD,Pfeiffer-Jensen M

    更新日期:2021-01-01 00:00:00

  • Polymyalgia rheumatica and chronic lymphatic leukaemia.

    abstract::A patient with polymyalgia rheumatica (PMR) is reported in whom, at the time of diagnosis, the number of lymphocytes in peripheral blood and bone marrow was normal. Lymphocytic infiltration typical of PMR was detected in renal and muscle biopsy specimens, and a liver fine-needle aspirate contained an abnormal lymphocy...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747709095438

    authors: von Knorring J,Selroos O

    更新日期:1977-01-01 00:00:00

  • Immunohistochemical demonstration of insulin-like growth factor I in inflammatory lesions in Wegener's granulomatosis and idiopathic midline destructive disease.

    abstract::The immunoreactivity of the trophic peptide insulin-like growth factor I (IGF-I; somatomedin C) was mapped in nasal mucosa biopsies from three patients with Wegener's granulomatosis (WG) and one with idiopathic midline destructive disease (IMDD; idiopathic midline granuloma). Strongly increased IGF-I immuno-reactivity...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909095410

    authors: Hansson HA,Petruson B,Petruson K

    更新日期:1989-01-01 00:00:00

  • Involvement of the lateral atlanto-axial joints as first and late symptom of rheumatoid arthritis.

    abstract::Thirty cases of unilateral or bilateral atlanto-axial arthritis are described. They were found among 606 RA patients. According to the degree of involvement, the 30 cases were divided into four groups: A. 16 cases. B. 5 cases. C. 7 cases. D. 2 cases. In two patients the atlanto-axial arthritis was the primary lesion. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165372

    authors: Kerckhove HV

    更新日期:1987-01-01 00:00:00

  • Clonal analysis of B cells in the synovial membrane of patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the clonal characteristics of B cells in the synovial membranes of rheumatoid arthritis (RA) patients. METHODS:The clonality of B cells at separate sites of the synovial membrane and other tissues from RA patients were investigated by a reverse transcriptase-polymerase chain reaction with a VH...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740310000346

    authors: Shiokawa S,Matsumato N,Nishimura J

    更新日期:2003-01-01 00:00:00

  • Cell proliferation in rheumatoid synovial tissue.

    abstract::Rheumatoid synovial tissue cell proliferation was studied by incubating fresh synovial tissue samples with [3H]-thymidine in vitro. The samples were collected at operation from 7 rheumatoid patients. It was found that 0.9-4.9% of the total cell population, excluding the synovial lining cells, became labelled. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747709095429

    authors: Nykänen PJ,Jyväsjärvi SH,Pätiälä HV

    更新日期:1977-01-01 00:00:00

  • Healing of erosions in rheumatoid arthritis remains elusive: results with 24 months of the anabolic agent teriparatide.

    abstract::Objective: Erosion healing in rheumatoid arthritis (RA) is difficult to demonstrate. This extension study aimed to determine whether 2 years of teriparatide (TPTD) produces erosion healing. Method: Subjects in a previous 12 month randomized controlled trial of TPTD in RA were invited to receive 12 additional months of...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1772362

    authors: Duryea J,Gravallese EM,Wortman JR,Xu C,Lu B,Kay J,Solomon DH

    更新日期:2021-01-01 00:00:00

  • The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome.

    abstract:OBJECTIVE:To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production. METHODS:We genotyped 111 unrelated German Caucasian patients with pSS and...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740801910353

    authors: Willeke P,Gaubitz M,Schotte H,Becker H,Domschke W,Schlüter B

    更新日期:2008-07-01 00:00:00

  • Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma.

    abstract:OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2010.549837

    authors: Danielides S,Mavragani CP,Katsakoulas I,Zintzaras E,Drosos AA,Vlachoyiannopoulos PG,Moutsopoulos HM

    更新日期:2011-01-01 00:00:00

  • Association between inflammasome-related polymorphisms and psoriatic arthritis.

    abstract::Objective: Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease associated with psoriasis. Underlying genetic factors are considered important for disease expression and prognosis of PsA. Interleukin-1β-regulating protein complexes called inflammasomes are associated with several inflammatory diseases, e....

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1834611

    authors: Juneblad K,Kastbom A,Johansson L,Rantapää-Dahlqvist S,Söderkvist P,Alenius GM

    更新日期:2020-12-10 00:00:00

  • The use of anthropometric measures in the prediction of incident gout: results from a Swedish community-based cohort study.

    abstract::Objectives: To study associations between different anthropometric measures and incident gout, and to find the best predictive measure. Method: We used the baseline investigation from the Malmö Diet and Cancer study, excluding cases of prevalent gout (n = 28 081). Cox regression for each anthropometric measurement was...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2019.1583368

    authors: Wändell P,Andreasson A,Hagström H,Kapetanovic MC,Carlsson AC

    更新日期:2019-07-01 00:00:00

  • Adherence to cardiovascular prevention strategies in patients with rheumatoid arthritis.

    abstract:OBJECTIVES:Patients with rheumatoid arthritis (RA) have a high risk of cardiovascular disease (CVD). Recent national and international guidelines suggest strict treatment of CVD risk factors in RA. The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in patients with RA. METHOD...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1028997

    authors: van Breukelen-van der Stoep DF,Zijlmans J,van Zeben D,Klop B,van de Geijn GJ,van der Meulen N,Hazes M,Birnie E,Castro Cabezas M

    更新日期:2015-01-01 00:00:00

  • Patients with primary Sjögren's syndrome treated for two months with evening primrose oil.

    abstract::Twenty-four female and 4 male patients, all fulfilling the Copenhagen criteria for primary Sjögren's syndrome (primary SS), were treated for 8 weeks with evening primrose oil (Efamol). Efamol is a seed oil which consists primarily of the n-6 essential fatty acids (EFA): cis-linoleic acid and gammalinolenic acid (GLA)....

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009748609102073

    authors: Oxholm P,Manthorpe R,Prause JU,Horrobin D

    更新日期:1986-01-01 00:00:00

  • IgG subclass distribution of autoantibodies against ribonucleoproteins.

    abstract::The IgG subclass distribution of anti-RNP antibodies was determined in sera from 34 patients. The antibodies were mainly of the complement-fixing IgG1 subclass with minor contributions of IgG3 and IgG4 antibodies. Selected sera contained IgG2 (non-complement fixing) anti-RNP antibodies and may possibly identify a subg...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748609092672

    authors: Hammarström L,Heigl Z,Smith CI

    更新日期:1986-01-01 00:00:00

  • Teeth loss and the inflammation of teeth-supporting tissues in rheumatoid disease.

    abstract::To compare the state of dentition between rheumatoid and control patients, ortopanthomograms were taken of 126 rheumatoid and 119 control patients. This roenthenologic examination revealed a signficantly higher incidence of teeth loss among the rheumatoid patients than among the control patients. To determine whether ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747509095615

    authors: Malmström M,Calonius PE

    更新日期:1975-01-01 00:00:00

  • Anti-cardiolipin antibodies, Raynaud's phenomenon with digital ischemia, and non small cell carcinoma of the lung.

    abstract::Raynaud's phenomenon, digital ischemia, antinuclear antibodies and anticardiolipin antibodies are uncommon features of malignancy. The association of all of these in a patient with malignancy has not previously been reported. We describe a 52 year old woman with non small-cell carcinoma of the lung who also had Raynau...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162978

    authors: Vaidya S,Logan JW

    更新日期:2001-01-01 00:00:00

  • The effect of HLA-DR antigens on the susceptibility to, and clinical expression of psoriatic arthritis.

    abstract:OBJECTIVE:To analyse the relative role of HLA-DR antigens in the susceptibility to, and clinical expression of psoriatic arthritis (PsA). PATIENTS AND METHODS:A retrospective cohort study of 120 patients with PsA who were assessed according to a standard protocol. Patients were classified in accordance with the predom...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740410005953

    authors: Queiro-Silva R,Torre-Alonso JC,Tinturé-Eguren T,López-Lagunas I

    更新日期:2004-01-01 00:00:00

  • Reiter's syndrome in Greenland. A clinical and epidermiological study of two communities.

    abstract::Patients with post-venereal Reiter's syndrome, living in the districts of Egedesminde and Jakobshavn in Greenland, were ascertained from medical records and patient examinations. Fifty-one patients were found to have definite Reiter's syndrome according to the ARA proposed criteria. The prevalence of the disease is 1....

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748509102040

    authors: Bardin T,Enel C,Lathrop M,Becker-Christensen F

    更新日期:1985-01-01 00:00:00

  • Immunoglobulin deposits in the dermo-epidermal junction zone in patients with systemic lupus erythematosus. Rheumatoid arthritis and temporal arteritis compared by serological testing including alpha2-macroglobulin.

    abstract::In biopsies from normal-looking skin, immune complexes in the dermo-epidermal junction zone were found by a direct immunofluorescence technique in 14 of 17 patients with systemic lupus erythematosus, in 6 of 12 patients with rheumatoid arthritis, but in none of 10 patients with temporal arteritis and 25 normal control...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747709095430

    authors: Permin H,Juhl F,Wiik A,Balslov JT

    更新日期:1977-01-01 00:00:00

  • Bone mineral density in fibromyalgia patients--correlation to disease activity.

    abstract:OBJECTIVE:To compare bone mass (BMD) in women with fibromyalgia (FM) with healthy females, and to evaluate whether self-reported pain and lack of functional capacity correlate to reduced BMD in FM patients. METHODS:Thirty-one FM patients (20 pre- and 11 postmenopausal) and fourty-one healthy women (30 pre- and 10 post...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740310002470

    authors: Jensen B,Wittrup IH,Bliddal H,Danneskiold-Samsøe B,Faber J

    更新日期:2003-01-01 00:00:00

  • Repair of bone erosions in rheumatoid arthritis: a systematic literature review.

    abstract::Objective: The aim of this study was to review the literature to identify studies reporting repair of erosions in rheumatoid arthritis (RA).Method: A systematic literature search for publications on the repair of erosions was performed in PubMed and Embase, limited to human adults and published in English. Titles, abs...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2019.1606274

    authors: Forslind K,Svensson B

    更新日期:2019-11-01 00:00:00

  • Influence of auranofin on lymphocyte membrane fluidity in rheumatoid arthritis. A fluorescence polarization study.

    abstract::Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748909102104

    authors: Beccerica E,Piergiacomi G,Curatola G,Ferretti G

    更新日期:1989-01-01 00:00:00

  • Predictive value of a multi-biomarker disease activity score for clinical remission and radiographic progression in patients with early rheumatoid arthritis: a post-hoc study of the OPERA trial.

    abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2018.1464206

    authors: Brahe CH,Østergaard M,Johansen JS,Defranoux N,Wang X,Bolce R,Sasso EH,Ørnbjerg LM,Hørslev-Petersen K,Stengaard-Pedersen K,Junker P,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Lottenburg

    更新日期:2019-01-01 00:00:00

  • Substance P receptor (NK1) gene expression in synovial tissue in rheumatoid arthritis and osteoarthritis.

    abstract::The distribution of messenger RNA coding for substance P receptor (NK1) in rheumatoid synovia and the relationship between signal intensity of NK1 mRNA and clinical parameters of disease activity were investigated. The synovia from 10 patients with rheumatoid arthritis (RA) and 7 patients with osteoarthritis was inves...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097498441010

    authors: Sakai K,Matsuno H,Tsuji H,Tohyama M

    更新日期:1998-01-01 00:00:00

  • Risk factors for reported influenza and influenza-like symptoms in patients with rheumatoid arthritis.

    abstract:OBJECTIVES:To determine the prevalence and predictors of influenza and influenza-like symptoms in patients with rheumatoid arthritis (RA). METHOD:Questionnaires were sent to patients registered as having RA and they were asked to fill in per month any period and details of influenza-like symptoms and vaccination. An e...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2012.670729

    authors: Dirven L,Huizinga TW,Allaart CF

    更新日期:2012-10-01 00:00:00