The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.

Abstract:

:YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthritic (n=9) and macroscopically normal (n=5) human articular cartilage, collected from 12 pre-selected areas of the femoral head, to discover a potential role for YKL-40 in cartilage remodelling in osteoarthritis. Immunohistochemical analysis showed that YKL-40 staining was found in chondrocytes of osteoarthritic cartilage mainly in the superficial and middle zone of the cartilage rather than the deep zone. There was a tendency for high number of YKL-40 positive chondrocytes in areas of the femoral head with a considerable biomechanical load. The number of chondrocytes with a positive staining for YKL-40 was in general low in normal cartilage. The present findings, together with previous observations, suggests that YKL-40 may be of importance in cartilage remodelling/degradation of osteoarthritic joints.

journal_name

Scand J Rheumatol

authors

Volck B,Ostergaard K,Johansen JS,Garbarsch C,Price PA

doi

10.1080/03009749950154257

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

171-9

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

28

pub_type

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