Subsets of activated T cells in patients with systemic lupus erythematosus: the relation to cell cycle.

Abstract:

:The correlation among the various markers of activated T cells (soluble interleukin 2 receptor (sIL-2R), HLA-DR+ and HLA-DP+ T cells, proliferating cell nuclear antigen (PCNA) positive lymphocytes) were examined in patients with systemic lupus erythematosus (SLE), and related to the cell cycle. The concentration of sIL-2R and the proportion of HLA-DR+ T cells, HLA-DP+ T cells or PCNA+ lymphocytes were increased significantly as compared to that in normal subjects. And, the concentrations of sIL-2R correlated with the proportions of PCNA+ lymphocytes, but not with the proportions of HLA-DR+ T cells, HLA-DP+ T cells. The correlation between sIL-2R and PCNA+ lymphocytes was attributed to both indicators being increased during the G1B or S phase in normal T cells upon stimulation by phytohemagglutinin (PHA). Upon cell cycle analysis it was learned that activated T cells could be found in the G1A and the S phases.

journal_name

Scand J Rheumatol

authors

Tokano Y,Morimoto S,Hishikawa T,Murashima A,Abe M,Sekigawa I,Takasaki Y,Hashimoto H,Okumura K,Shirai T,Hirose S

doi

10.3109/03009749709065662

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

37-42

issue

1

eissn

0300-9742

issn

1502-7732

journal_volume

26

pub_type

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