A five day course of high dose corticosteroids has no effect on the clearance of soluble aggregates of human immunoglobulin G in healthy volunteers.

Abstract:

:It is thought that glucocorticosteroids impair the clearance of immune complexes by the mononuclear phagocyte system (MPS). We studied the effect of a five day course of prednisone (1 mg/kg body weight per day) on MPS function in 10 healthy volunteers, using soluble radiolabeled aggregates of human immunoglobulin G as a probe. MPS function was assessed before steroid treatment, and again 24 hours after the last dose of prednisone. Elimination kinetics and the uptake of the immunoglobulin aggregates by liver and spleen did not change after prednisone treatment. This suggests that, in contrast to general belief, high doses of glucocorticosteroids have no direct, acute effect on MPS function.

journal_name

Scand J Rheumatol

authors

Halma C,Daha MR,Evers-Schouten JH,Pauwels EK,van Es LA

doi

10.3109/03009749209095084

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

129-33

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

21

pub_type

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