Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma.

Abstract:

OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [46 with diffuse (dSSc) and 92 with limited scleroderma (lSSc)] and 100 healthy controls (HC) were tested for the presence of ATA [anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies] using a commercial enzyme-linked immunosorbent assay (ELISA). Clinical and serological data were recorded. RESULTS:An increased prevalence of anti-TPO but not anti-Tg antibodies was detected in patients with SSc compared to HC (27.5% vs. 14%, p = 0.016). Of note, a statistically significant increase of anti-TPO was detected only in patients with lSSc compared to HC (32.6% vs. 14%, p = 0.003). No correlations with other clinical features were detected. CONCLUSIONS:An increased prevalence of anti-TPO antibodies was identified in patients with lSSc. We propose that ATA testing should be offered to this subgroup of patients.

journal_name

Scand J Rheumatol

authors

Danielides S,Mavragani CP,Katsakoulas I,Zintzaras E,Drosos AA,Vlachoyiannopoulos PG,Moutsopoulos HM

doi

10.3109/03009742.2010.549837

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

299-303

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

40

pub_type

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