Abstract:
:In an effort to clarify factors related to the pathogenesis of experimental osteoarthritis, biochemical alterations were studied in articular soft tissues of adult rabbits through the immobilization of the knee of the hind leg in extension for 3, 7, 11, 18, 35 or 56 days. The medial collateral ligament and medial meniscus of the knee, as well as the joint capsule of the hip, were analysed. Total protein synthesis (measured by [3H]proline incorporation) increased in the immobilized legs in all of the tissues examined. The collagen synthesis rate (estimated by specific radioactivity of hydroxyproline) in the medial collateral ligament was enhanced, whereas the collagen content (measured as hydroxyproline concentration) of the tissue declined temporarily. This observation suggests that the collagen degradation rate transiently exceeds that of collagen synthesis. The results indicate that distinct biochemical alterations occur in the periarticular tissues during the early phases of immobilization-induced osteoarthritis. It is of interest that biochemical changes similar to those of the immobilized leg were seen, to a lesser extent, in the structures of the contralateral nonimmobilized leg.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Eronen I,Videman T,Kurppa Kdoi
10.3109/03009748409100374subject
Has Abstractpub_date
1984-01-01 00:00:00pages
121-8issue
2eissn
0300-9742issn
1502-7732journal_volume
13pub_type
杂志文章abstract::In psoriatic spondylitis, the complication of cervical cord compression with myelopathy is rare. We present a case of psoriatic spondylitis causing cervical myelopathy which required surgical intervention, and review the literature of reported neurological complications in psoriatic spondylitis. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749609104069
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:A proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are B-cell stimulation and survival molecules. We have investigated whether APRIL and/or BAFF activity is enhanced in the systemic and/or intrathechal compartment of patients with neuropsychiatric systemic lupus erythematosus (NPSLE)...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2010.550900
更新日期:2011-01-01 00:00:00
abstract::The intestinal permeability to polyethyleneglycols (PEGs) of varying size in patients with rheumatoid arthritis has been investigated. Permeability was determined by measuring the 6-hour urinary recovery of different-sized PEGs after oral intake of PEG 400, PEG 1000, or PEG 3000. Patients with rheumatoid arthritis exc...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309102897
更新日期:1983-01-01 00:00:00
abstract::Background: Chronic inflammation, as determined by persistently elevated acute-phase reactants in attack-free periods, can occasionally be observed in patients with familial Mediterranean fever (FMF) and is suggested to be a risk factor for the development of amyloidosis. We aimed to investigate the underlying causes ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2018.1558282
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate the possible effects of vimentin (Vim) and citrullinated Vim (cVim) on proliferation capacity, pro-inflammatory cytokine secretion, and the expression of peptidylarginine deiminase type 4 (PADI4) and receptor activator of nuclear factor kappa B ligand (RANKL) in cultured fibroblast-li...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.670263
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of adalimumab, etanercept, and infliximab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX) by calculating the number needed to treat (NNT) using three different methods. METHODS:A systematic literature search of the Cochrane Library, MEDLINE...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.1080/03009740701607067
更新日期:2007-11-01 00:00:00
abstract::Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097498440877
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To investigate the clonal characteristics of B cells in the synovial membranes of rheumatoid arthritis (RA) patients. METHODS:The clonality of B cells at separate sites of the synovial membrane and other tissues from RA patients were investigated by a reverse transcriptase-polymerase chain reaction with a VH...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740310000346
更新日期:2003-01-01 00:00:00
abstract::Antibodies to three major antigens of the non-histone or saline-extractable nuclear antigen (ENA) complex were sought by counterimmunoelectrophoresis (CEP) in three groups of sera which gave different patterns in the immunofluorescence test for antinuclear antibodies (ANA). Precipitins, mainly anti RNP and anti SS-B, ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748409111300
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The diagnosis of Achilles and patella tendinitis has until recently been based on clinical examination, and treatment with local steroid injection has been given blindly. This is the first randomized, double blind, placebo-controlled study of local steroid injection in athletes with chronic tendinitis, which...
journal_title:Scandinavian journal of rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/03009740310004126
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:Calcium hydroxyapatite (HA) is reported to be the major constituent of soft tissue calcinosis in patients with scleroderma (systemic sclerosis, SSc). Mechanical stress and local tissue hypoxia are thought to be important in the pathogenesis of SSc calcinosis. We sought to analyse spontaneously draining mater...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2016.1219766
更新日期:2017-03-01 00:00:00
abstract::Rate of grip development (power), time to reach maximum grip strength and fatigue were not affected by the diurnal variation known to influence maximum grip strength and work during grip formation in normal subjects. Rheumatoid hands were less affected by exercise or temperature change of the forearm than were normal ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748209098173
更新日期:1982-01-01 00:00:00
abstract::In studies on 779 fresh, unselected ANA+ sera, 50 (6.4%) were found to have anti-dsDNA antibodies, by using CIP (C. luciliae immunoperoxidase), and 84% of the 50 patients met the criteria for definite SLE. After freezing 36 of these sera for 13 +/- 1 months, only 52.8% were again positive by CIP. Using CIF (C. lucilia...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748509102043
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To estimate the heritability of Kashin-Beck disease (KBD) in first-degree relatives and to identify chromosome regions likely to contain susceptibility loci for KBD. METHODS:A total of 331 probands with confirmed KBD in their pedigrees were selected from 9331 residents in 17 KBD villages of Linyou county, no...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009740903270599
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. METHODS:Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740510026751
更新日期:2006-01-01 00:00:00
abstract::In 1974-76 patients with early rheumatoid arthritis (duration less than or equal to 6 months) were investigated at the Institute for Rheumatism, Moscow, and at the Rheumatism Foundation Hospital, Heinola, Finland. Of 200 patients in each centre, 142 sex- and age-matched patients were chosen and followed up for one yea...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the gustatory and olfactory functions of patients with rheumatoid arthritis (RA) compared to sex- and age-matched healthy subjects and to investigate a potential relationship between disease activity [using the 28-joint Disease Activity Score (DAS28)] and chemosensory capacity. Furthermore, to di...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2010.517547
更新日期:2011-05-01 00:00:00
abstract::Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748909102104
更新日期:1989-01-01 00:00:00
abstract::To obtain data on the incidence of Reiter's syndrome (RS) as well as on possible simultaneously appearing signs and symptoms of RS in sexual couples we have made interview reports of randomly selected 530 persons: 219 males and 311 females, aged 15 to 54. None had RS. Six males (2.7%) and seven females (2.3%) had a hi...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748209098181
更新日期:1982-01-01 00:00:00
abstract::Fifty-one patients with different connective tissue diseases in either active or clinically inactive phase were studied to detect the incidence of chronic or subclinical consumption coagulopathy in these forms. Every patient received intravenously 20 mu Ci of [125I] fibrinogen and the clearance of the labeled fibrinog...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748009112361
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:Sarcoidosis is a chronic granulomatous disease. Pyrin has anti-inflammatory activity in the regulation of inflammasomes and is encoded by the Mediterranean fever (MEFV) gene. MEFV gene mutations trigger the inflammatory cascade and cause familial Mediterranean fever (FMF). A relationship between various rheu...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2015.1092580
更新日期:2016-01-01 00:00:00
abstract::Preliminary studies indicate that plasma zinc concentrations, as estimated by atomic absorption spectrophotometry, are reduced in rheumatoid arthritis. A relationship has also been established between metacarpal index of osteoporosis and plasma zinc concentrations in rheumatoid subjects. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747509165264
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. METHODS:A total of 138 patients with SSc [...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2010.549837
更新日期:2011-01-01 00:00:00
abstract::Adult Still's disease (ASD) is a rare systemic disorder characterized by fever, arthralgia, cutaneous rash, and lymphadenopathy, with high polymorphonuclear leucocytosis and low glycosylated ferritinaemia. Kidney involvement has been reported rarely. We present a patient with ASD who developed haemolytic uraemic syndr...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740510026689
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:We investigated the antibody levels against early antigens of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV6) in systemic lupus erythematosus (SLE) patients and healthy controls, and further correlated these antibodies to haematology/biochemistry, serology, and disease activit...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2014.973061
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of magnetic resonance imaging (MRI)-guided high power focused ultrasound (FUS) to perform synovectomy noninvasively. METHODS:Five New Zealand white male rabbit knees with experimentally induced arthritis underwent MRI-guided thermal surgery by high power (60 W/10 s) sonication....
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009749950155607
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The painDETECT questionnaire (PDQ) is a mechanism-based pain classification tool assigning patients to one of three categories depending on the quality of the experienced pain. Patients with non-nociceptive pain score high on the PDQ. The objective was to assess the proportions of the three PDQ classificatio...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2016.1139174
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:Schnitzler syndrome (SchS) is an autoinflammatory disorder characterized by chronic urticaria, fever, and monoclonal gammopathy. The success of interleukin-1 (IL-1) blocking therapies suggests a crucial role for IL-1 in disease induction. The aim of this study is to perform a comprehensive analysis of IL-1 f...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2018.1550210
更新日期:2019-05-01 00:00:00
abstract::The aim of this study was to evaluate the presence of PAF-acether (PAF), its specific degrading enzyme acetylhydrolase, and tumor necrosis factor (TNF) concentrations in blood and synovial fluid (SF) from patients with active RA. The variations of the mediators were also evaluated after corticosteroid perfusions in 7 ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749509099308
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Association with human leukocyte antigen (HLA)-DRB alleles, implicated in the aetiopathogenesis of rheumatoid arthritis (RA), is found to be different in various ethnic groups. This study aimed to investigate DRB1 alleles in RA patients in Turkey, and to examine the effect of these alleles on disease severity...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740310003901
更新日期:2003-01-01 00:00:00