Antibody profiles of sera giving different nuclear staining patterns.

Abstract:

:Antibodies to three major antigens of the non-histone or saline-extractable nuclear antigen (ENA) complex were sought by counterimmunoelectrophoresis (CEP) in three groups of sera which gave different patterns in the immunofluorescence test for antinuclear antibodies (ANA). Precipitins, mainly anti RNP and anti SS-B, were found most commonly (61%) in 70 sera with a speckled ANA pattern but were less frequent (8%) in 61 sera with a homogeneous ANA pattern and exceptional (1%) in 72 sera which showed fibrillar ANA staining. Rim staining was an insensitive indicator of nDNA antibody. An enzyme immunoassay (EIA), specific for anti-SS-B was more sensitive than CEP and identified this antibody in 28 sera, compared with 18 for CEP.

journal_name

Scand J Rheumatol

authors

Wangel AG,Teppo AM,Pollard A,Howarth S

doi

10.3109/03009748409111300

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

303-9

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

13

pub_type

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