Abstract:
:The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovial membrane volume was significantly reduced (median -52%) in all 9 patients brought into clinical remission (p < 0.01), while no significant change was found in patients with clinical relapse. The early synovial enhancement was not significantly changed. MRI revealed progressive erosive changes in 2 patients. The time of relapse was correlated to a MR-erosion score, but not to early synovial enhancement or volumes of synovium or effusion (Spearman tests). MRI-determined synovial membrane volumes and early synovial enhancement may be objective quantitative markers of inflammation. MR-scores of cartilage and bone erosions are sensitive to progressive changes occurring within a month.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Ostergaard M,Stoltenberg M,Gideon P,Wieslander S,Sonne-Holm S,Kryger P,Sonne Mdoi
10.3109/03009749509095146subject
Has Abstractpub_date
1995-01-01 00:00:00pages
5-12issue
1eissn
0300-9742issn
1502-7732journal_volume
24pub_type
杂志文章abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/03009742.2018.1464206
更新日期:2019-01-01 00:00:00
abstract::Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748909102104
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:Ischaemic digital ulcers (DUs) are a common complication of systemic sclerosis (SSc). This study aimed to characterize patients with SSc and ongoing DUs treated with the endothelin receptor antagonist bosentan in clinical practice in France. METHOD:An observational, retrospective, longitudinal study was con...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/03009742.2014.887768
更新日期:2014-01-01 00:00:00
abstract::The clinical outcome and tolerability following treatment with samarium-153 particulate hydroxyapatite was evaluated in patients with persistent rheumatoid knee synovitis. The clinical review of 18 patients treated with intra-articular samarium-153 particulate hydroxyapatite combined with triamcinolone hexacetonide wh...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749609065647
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and predictors of influenza and influenza-like symptoms in patients with rheumatoid arthritis (RA). METHOD:Questionnaires were sent to patients registered as having RA and they were asked to fill in per month any period and details of influenza-like symptoms and vaccination. An e...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2012.670729
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To compare the risk of acute coronary syndrome (ACS) between patients with and without ankylosing spondylitis (AS). METHOD:This retrospective cohort study identified all patients with AS aged ≥ 18 years newly diagnosed from 2000 to 2009, registered in the National Health Insurance Research Database (NHIRD) ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2013.822097
更新日期:2014-01-01 00:00:00
abstract::A case of gold-induced enterocolitis in a 69-year-old female with rheumatoid arthritis who had received the new gold compound by oral administration (Auranofin (AF) for 4 weeks) is reported. Mild diarrhoea is a commonly described side effect accompanying AF, but in this case a severe colitis developed. The course of t...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309098544
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. METHODS:Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740510026751
更新日期:2006-01-01 00:00:00
abstract::Objective: The aim of this study was to review the literature to identify studies reporting repair of erosions in rheumatoid arthritis (RA).Method: A systematic literature search for publications on the repair of erosions was performed in PubMed and Embase, limited to human adults and published in English. Titles, abs...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2019.1606274
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Interleukin-1 (IL-1) has been implicated in the pathogenesis of several rheumatic inflammatory diseases, including adult-onset Still's disease (AOSD) and systemic-onset juvenile idiopathic arthritis (SoJIA). Several clinical trials also suggest that anakinra, a human recombinant interleukin-1 receptor antagon...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740701340081
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular and biochemical profile of skeletal muscle mitochondria of patients with isolated polymyalgia rheumatica (PMR). PATIENTS AND METHODS:We included patients with a recent diagnosis of PMR and as control healthy individuals submitted to orthopedic surgery. Skeletal muscle was obtaine...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009749950155526
更新日期:1999-01-01 00:00:00
abstract::The risk of a disease flare-up and the side-effects experienced during the use of oral contraceptives (OCs) were studied in 85 female SLE patients, 18-44 years old, regularly attending two specialist rheumatological clinics. Thirty-one patients had used combined oral contraceptives (cOCs) during or after the onset of ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749109096822
更新日期:1991-01-01 00:00:00
abstract::Background: Chronic inflammation, as determined by persistently elevated acute-phase reactants in attack-free periods, can occasionally be observed in patients with familial Mediterranean fever (FMF) and is suggested to be a risk factor for the development of amyloidosis. We aimed to investigate the underlying causes ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2018.1558282
更新日期:2019-07-01 00:00:00
abstract::Fc-receptors for IgG (Fc gamma R) are important triggers of effector function in macrophages. We have investigated the distribution of cells bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in 14 synovia and 3 nodules from rheumatoid arthritis (RA) patients, using monoclonal antibodies on serial cryostat sectio...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749009102116
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. METHOD:A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2013.786755
更新日期:2013-01-01 00:00:00
abstract::Objective: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease. Studies suggest that pro-inflammatory cytokines may be attenuated by the vagus nerve through the cholinergic anti-inflammatory pathway. We aimed to evaluate the anti-inflammatory effects of short-term transcutaneous non-invasive vagus...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2020.1764617
更新日期:2021-01-01 00:00:00
abstract::Based on open studies. D-penicillamine (DPA) has been used for the treatment of systemic sclerosis (SSc) but we believe the controlled trial of this drug in SSc does not support its use to treat this disease. Open trials are inevitably biased by selection bias and randomized, blinded, controlled studies are required t...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.1080/030097401316909495
更新日期:2001-01-01 00:00:00
abstract::Immobilization of a rabbit leg in extension results in the early development of an aseptic inflammation, synovial effusion and stiffening, and subsequent osteoarthritis of the knee. To study the pathogenesis of this experimental osteoarthritis, the hydrostatic pressures were measured in the knee, and distal metaphysis...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748809098756
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:We investigated the antibody levels against early antigens of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV6) in systemic lupus erythematosus (SLE) patients and healthy controls, and further correlated these antibodies to haematology/biochemistry, serology, and disease activit...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2014.973061
更新日期:2015-01-01 00:00:00
abstract::Rheumatoid synovial tissue cell proliferation was studied by incubating fresh synovial tissue samples with [3H]-thymidine in vitro. The samples were collected at operation from 7 rheumatoid patients. It was found that 0.9-4.9% of the total cell population, excluding the synovial lining cells, became labelled. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747709095429
更新日期:1977-01-01 00:00:00
abstract::Objective: Pain is a common and distressing feature of juvenile idiopathic arthritis (JIA). Pain interference (PI) is underexplored in long-term conditions such as JIA. The aim of this study was to explore the factors associated with PI in young adults with JIA. Methods: All consecutive JIA patients aged 18-30 years i...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/03009742.2019.1596308
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To determine the effect of inflammation through exposure to tumour necrosis factor (TNF)alpha on T lymphocytes in patients with systemic lupus erythematosus (SLE). METHODS:We studied the effect of TNFalpha on T-lymphocyte apoptosis in patients with SLE, rheumatoid arthritis (RA), and in healthy controls. Apo...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009740802409496
更新日期:2009-03-01 00:00:00
abstract::The right knee of adult rabbits was immobilized in extension for 5 weeks. The rabbits were then allowed to move freely for 8 weeks. Some rabbits were given 100 mg of ibuprofen (Brufen) daily per os during the immobilization and remobilization periods. The controls were not given any drug. The development of the thickn...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748009098145
更新日期:1980-01-01 00:00:00
abstract::Four patients with systemic sclerosis (scleroderma) were treated with (D)-penicillamine (1.2-1.8 g/d) for 18-60 months. All patients improved. Vital capillary microscopy demonstrated that the number of visible skin capillaries increased during therapy, thus indicating a more efficient nutritional circulation. ...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747709095427
更新日期:1977-01-01 00:00:00
abstract::This paper reports the effects of peroral administration of the two non-steroid anti-inflammatory drugs ibuprofen and flubiprofen on orthotopic and induced heterotopic bone. The treatment induced no effects on the mineral or hydroxyproline contents of femur compared with a control group. Nor could any generalized toxi...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748309102907
更新日期:1983-01-01 00:00:00
abstract::A patient with polymyalgia rheumatica (PMR) is reported in whom, at the time of diagnosis, the number of lymphocytes in peripheral blood and bone marrow was normal. Lymphocytic infiltration typical of PMR was detected in renal and muscle biopsy specimens, and a liver fine-needle aspirate contained an abnormal lymphocy...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009747709095438
更新日期:1977-01-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and serositis. Typical attacks of FMF last 3 to 5 days. Fever and myalgia are not always improved by colchicine therapy and sometimes require steroid therapy. We present two cases of severe prolonged febrile myalgia where steroid therapy...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/030097400447615
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To apply the Rasch model to the Norwegian version of the Arthritis Self-Efficacy Scale (ASES). METHOD:The ASES was included in a self-administered questionnaire sent to 224 patients attending one of three rehabilitation centres for rheumatic diseases in Norway in 2009. The fit of the ASES to the Rasch model...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2016.1155644
更新日期:2017-01-01 00:00:00
abstract::With improved disease survival, arterial thromboembolism has become an important cause of morbidity in patients with systemic lupus erythematosus (SLE). A number of conventional and non-conventional risk factors are associated with accelerated atherosclerosis. Regular surveillance and control of traditional risk facto...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章,评审
doi:10.1080/03009740600601526
更新日期:2006-03-01 00:00:00
abstract::The aetiology of ankylosing spondylitis (AS) may involve certain enterobacteria. It is therefore interesting that serum polymeric IgA, a precursor of secretory IgA, was statistically elevated in active AS (n = 35) and that levels were comparable to those found in yersiniosis (n = 12); this might indicate antigenic sti...
journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009748609092598
更新日期:1986-01-01 00:00:00