Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs.

Abstract:

:This paper reports the effects of peroral administration of the two non-steroid anti-inflammatory drugs ibuprofen and flubiprofen on orthotopic and induced heterotopic bone. The treatment induced no effects on the mineral or hydroxyproline contents of femur compared with a control group. Nor could any generalized toxic effects of the treatment be detected with respect to bodyweights or serum values of calcium, phosphate or albumin. Treatment with the drugs was commenced one week before initiating the heterotopic bone formation by implanting pieces of demineralized bone matrix in the abdominal muscle of growing rats. A significant decrease in specific amounts of calcium and phosphate was noted in the induced new-formed bone 4 weeks after implantation, whereas no such effect was apparent 2 weeks after implantation.

journal_name

Scand J Rheumatol

authors

Törnkvist H,Nilsson OS,Bauer FC,Lindholm TS

doi

10.3109/03009748309102907

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

177-80

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

12

pub_type

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