Abstract：
:Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus previous Disease Activity Scores, as they lack the time component. We propose a longitudinal approach that identifies subgroups of patients while capturing their evolution across several clinical outcomes simultaneously (multi-trajectories). Method: For exploration, the RA cohort BARFOT (n = 2829) was used to identify 24 month post-diagnosis simultaneous trajectories of 28-joint Disease Activity Score and its components. Measurements were available at inclusion (0), 3, 6, 12, 24, and 60 months. Multi-trajectories were found with latent class growth modelling. For validation, the TIRA-2 cohort (n = 504) was used. Radiographic changes, assessed by the modified Sharp van der Heijde score, were correlated with trajectory membership. Results: Three multi-trajectories were identified, with 39.6% of the patients in the lowest and 18.9% in the highest (worst) trajectory. Patients in the worst trajectory had on average eight tender and six swollen joints after 24 months. Radiographic changes at 24 and 60 months were significantly increased from the lowest to the highest trajectory. Conclusion: Multi-trajectories constitute a powerful tool for identifying subgroups of RA patients and could be used in future studies searching for predictive biomarkers for disease progression. The evolution and shape of the trajectories in TIRA-2 were very similar to those in BARFOT, even though TIRA-2 is a newer cohort.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Leu Agelii M,Andersson M,Jones BL,Sjöwall C,Kastbom A,Hafström I,Forslind K,Gjertsson Idoi
10.1080/03009742.2020.1774646subject
Has Abstractpub_date
2021-01-01 00:00:00pages
1-10issue
1eissn
0300-9742issn
1502-7732journal_volume
50pub_type
杂志文章abstract：:Antibodies to soluble ribonucleoprotein (sRNP) are by definition a prerequisite for the diagnosis mixed connective tissue disease (MCTD). They are also found in 30--40% of other rheumatic conditions with a high titred speckled IFL reaction. The same is true for the most characteristic clinical features of MCTD, viz. R...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747809095661
更新日期：1978-01-01 00:00:00
abstract：:Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnorma...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097400750041433
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:To compare the prognosis of subacromial impingement (SAI) stage II treated conservatively or with subacromial decompression. METHODS:A follow-up study after 4-8 years in a randomized controlled trial (RCT) with 90 adult cases with SAI treated in a Danish hospital from 1996 to 2000 with graded physiotherapy ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1080/03009740600556167
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To determine the effect of inflammation through exposure to tumour necrosis factor (TNF)alpha on T lymphocytes in patients with systemic lupus erythematosus (SLE). METHODS:We studied the effect of TNFalpha on T-lymphocyte apoptosis in patients with SLE, rheumatoid arthritis (RA), and in healthy controls. Apo...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740802409496
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:Cationic lipid complexes bind to angiogenic endothelial cells of solid tumours and microvessels of chronic inflammatory tissue. Methotrexate (MTX) is one of the drugs used in the therapy of rheumatoid arthritis (RA); it is applied systemically but can have serious side-effects. The aim of this study was to i...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1030448
更新日期：2015-01-01 00:00:00
abstract：:The aetiology of ankylosing spondylitis (AS) may involve certain enterobacteria. It is therefore interesting that serum polymeric IgA, a precursor of secretory IgA, was statistically elevated in active AS (n = 35) and that levels were comparable to those found in yersiniosis (n = 12); this might indicate antigenic sti...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748609092598
更新日期：1986-01-01 00:00:00
abstract：:Medium from cultured bovine synovial membrane when applied to articular cartilage from the same animal enhanced proteoglycan breakdown, as measured by the release of [35S]sulphate from prelabelled cartilage, principally by activating chondrocytes to secrete or activate their own enzymes. This effect persisted whether ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748209098113
更新日期：1982-01-01 00:00:00
abstract：:This study is the first report of the permeability status of nailfold capillaries in psoriatic arthritis (PA). "Traditional" nailfold capillary microscopy and intravital fluorescence videomicroscopy were carried out at the nailfold of 13 patients with PA. Twenty five healthy subjects served as controls for nailfold ca...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749209099229
更新日期：1992-01-01 00:00:00
abstract：:To study the role of copper in inflammatory rheumatic diseases, serum copper, serum ceruloplasmin concentration, erythrocyte sedimentation rate, and radio-copper studies were performed in 11 male patients with ankylosing spondylitis, in 12 female patients with rheumatoid arthritis and in 7 normal male subjects. The oc...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747809098838
更新日期：1978-01-01 00:00:00
abstract：OBJECTIVE:Platelets are thought to participate in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthritis (RA). We showed recently an in vivo increase in platelet-endothelial cell interactions in mice with antigen-induced arthritis (AiA). The underlying mechanisms are not yet clear. The aim of th...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740701218741
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics. METHODS:A retrospective study of clinical, sonographic and radiological examinations of the shoulders of 100 ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748909102104
更新日期：1989-01-01 00:00:00
abstract：:The right knee of adult rabbits was immobilized in extension for 5 weeks. The rabbits were then allowed to move freely for 8 weeks. Some rabbits were given 100 mg of ibuprofen (Brufen) daily per os during the immobilization and remobilization periods. The controls were not given any drug. The development of the thickn...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748009098145
更新日期：1980-01-01 00:00:00
abstract：:X-rays of 20 finger joints, 10 foot joints and 2 wrists of 50 female patients with seropositive rheumatoid arthritis of 10-15 years' duration from 1962, 1972, 1982 and 1992 were evaluated blindly for erosions. A highly significant decline was observed in erosions in finger joints. Erosions had also declined in wrists ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749409102128
更新日期：1994-01-01 00:00:00
abstract：:An investigation has been carried out on the presence of iron in striated muscle from normal individuals and from patients with rheumatoid disease. The methods used for the estimation of iron required a neutron activation analysis of total iron and extraction of hemoglobin in cyanide buffer. The results disclosed that...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747609099906
更新日期：1976-01-01 00:00:00
abstract：:SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) is a new sulfhydryl compound having a relatively similar chemical structure to Tiopronin and D-penicillamine. An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and wit...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.3109/03009748609092674
更新日期：1986-01-01 00:00:00
abstract：:Biopsy specimens of human articular cartilage were taken from the caudal summits and from the posterior part of both epicondyles of the right lower femoral epiphysis of 20 individuals within 12 hours post mortem. 12 articular surfaces were normal and 8 included changes attributable to osteoarthrosis. In one individual...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:To analyse the relative role of HLA-DR antigens in the susceptibility to, and clinical expression of psoriatic arthritis (PsA). PATIENTS AND METHODS:A retrospective cohort study of 120 patients with PsA who were assessed according to a standard protocol. Patients were classified in accordance with the predom...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740410005953
更新日期：2004-01-01 00:00:00
abstract：:The clinical outcome and tolerability following treatment with samarium-153 particulate hydroxyapatite was evaluated in patients with persistent rheumatoid knee synovitis. The clinical review of 18 patients treated with intra-articular samarium-153 particulate hydroxyapatite combined with triamcinolone hexacetonide wh...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749609065647
更新日期：1996-01-01 00:00:00
abstract：:Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.3109/03009749709065702
更新日期：1997-01-01 00:00:00
abstract：:This paper reports the effects of peroral administration of the two non-steroid anti-inflammatory drugs ibuprofen and flubiprofen on orthotopic and induced heterotopic bone. The treatment induced no effects on the mineral or hydroxyproline contents of femur compared with a control group. Nor could any generalized toxi...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748309102907
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVES:To provide a thorough description of team rehabilitation care and compare the structure, process, and outcomes in two specialized arthritis rehabilitation settings. METHODS:Patients with inflammatory arthritis scheduled for inpatient rehabilitation in seven specialized rehabilitation centres and three rheum...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,多中心研究
doi：10.3109/03009742.2011.601757
更新日期：2012-02-01 00:00:00
abstract：:Immobilization of a rabbit leg in extension results in the early development of an aseptic inflammation, synovial effusion and stiffening, and subsequent osteoarthritis of the knee. To study the pathogenesis of this experimental osteoarthritis, the hydrostatic pressures were measured in the knee, and distal metaphysis...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748809098756
更新日期：1988-01-01 00:00:00
abstract：:Objective: Pain is a common and distressing feature of juvenile idiopathic arthritis (JIA). Pain interference (PI) is underexplored in long-term conditions such as JIA. The aim of this study was to explore the factors associated with PI in young adults with JIA. Methods: All consecutive JIA patients aged 18-30 years i...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1080/03009742.2019.1596308
更新日期：2019-09-01 00:00:00
abstract：:Free, total, and peptide hydroxyproline levels were determined in synovial fluid obtained from the knee joints of 60 patients with theumatoid arthritis (RA), and 26 patients with degenerative joint disease. In addition, in 160 synovial fluid samples obtained from 121 patients including 50 with degenerative joint disea...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747509095617
更新日期：1975-01-01 00:00:00
abstract：:In the general population of 39,418 persons within areas in the counties of Norrbotten (BD), Jämtland (Z), Skaraborg (R), Kristianstad west coast (LV), and Kristianstad east coast (L) in Sweden all the inhabitants over the age of seven (in Norrbotten over the age of 14) were investigated for the total number of cases ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747009165382
更新日期：1987-01-01 00:00:00
abstract：:A case of bilateral temporomandibular joint (TMJ) ankylosis in a Chinese male patient with ankylosing spondylitis is presented. A review of the literature emphasizes the rarity of this arthro-pathology in ankylosing spondylitis. The importance in the recognition of this complication by clinical examination supplemente...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749709115833
更新日期：1997-01-01 00:00:00
abstract：:Case 1. A 20-year-old woman presented 4 weeks post-partum with widespread symmetrical inflammatory polyarthropathy with marked synovitis. Investigations revealed grossly raised CRP with negative immunology screen. A few days before presentation she saw her general practitioner with left-sided mastitis, which then deve...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097400750001978
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1080/03009742.2018.1464206
更新日期：2019-01-01 00:00:00
abstract：:A case of gold-induced enterocolitis in a 69-year-old female with rheumatoid arthritis who had received the new gold compound by oral administration (Auranofin (AF) for 4 weeks) is reported. Mild diarrhoea is a commonly described side effect accompanying AF, but in this case a severe colitis developed. The course of t...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748309098544
更新日期：1983-01-01 00:00:00
