The safety profile of low-dose cladribine in refractory rheumatoid arthritis. A pilot trial.

Abstract:

:Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given a subcutaneous dosage of 0.05 mg/kg 2-CdA weekly over a period of 8 weeks. Of the lymphocyte subsets, both T and B cells decreased below the normal range, whereas natural killer cells remained stable. These changes were the only side-effects noted during treatment and 4 weeks afterwards. In one patient a pacemaker was implanted for reasons unlikely to be related to 2-CdA administration. We conclude that even low-dose 2-CdA (0.05 mg/kg) can decrease T and B cell populations in patients with refractory RA, but other side-effects are unlikely. For assessing the possible clinical efficacy of low-dose 2-CdA further studies are warranted.

journal_name

Scand J Rheumatol

authors

Schirmer M,Mur E,Pfeiffer KP,Thaler J,Konwalinka G

doi

10.3109/03009749709065702

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

376-9

issue

5

eissn

0300-9742

issn

1502-7732

journal_volume

26

pub_type

临床试验,杂志文章
  • Differentiation between early rheumatoid arthritis patients and healthy persons by conventional and dynamic contrast-enhanced magnetic resonance imaging.

    abstract:OBJECTIVES:To identify the magnetic resonance imaging (MRI) parameter that best differentiates healthy persons and patients with early rheumatoid arthritis (RA), and to investigated responsiveness to treatment of various MRI parameters. METHOD:Conventional MRI and dynamic contrast-enhanced (DCE)-MRI of the hand were p...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2013.824022

    authors: Axelsen MB,Ejbjerg BJ,Hetland ML,Skjødt H,Majgaard O,Lauridsen UB,Hørslev-Petersen K,Boesen M,Kubassova O,Bliddal H,Østergaard M

    更新日期:2014-01-01 00:00:00

  • Nailfold capillary permeability in psoriatic arthritis.

    abstract::This study is the first report of the permeability status of nailfold capillaries in psoriatic arthritis (PA). "Traditional" nailfold capillary microscopy and intravital fluorescence videomicroscopy were carried out at the nailfold of 13 patients with PA. Twenty five healthy subjects served as controls for nailfold ca...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209099229

    authors: Grassi W,Core P,Carlino G,Cervini C

    更新日期:1992-01-01 00:00:00

  • Gastrointestinal blood loss during treatment with naproxen for rheumatoid arthritis.

    abstract::In 9 patients with active rheumatoid arthritis we studied gastrointestinal blood loss during well tolerated therapy with the non-steroidal anti-inflammatory drug naproxen, 500 mg twice daily. The mean gastrointestinal blood loss, assessed with reinfused autologous 51Cr-labelled erythrocytes, was 1.4 +/- 0.6 ml/day (me...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748709102509

    authors: van den Ouweland FA,Corstens FH,van de Putte LB,Gribnau FW

    更新日期:1987-01-01 00:00:00

  • Dactylitis, a term for different digit diseases.

    abstract::Dorland's Illustrated Medical Dictionary gives the following definition of dactylitis (deltaalphachitauupsilonlambdaomicronsigma = digit): 'inflammation of a finger or toe'. Although any inflammatory process involving the fingers or toes may be called dactylitis, the term has entered in current use only in some well-d...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,评审

    doi:10.1080/03009740600906677

    authors: Olivieri I,Scarano E,Padula A,Giasi V,Priolo F

    更新日期:2006-09-01 00:00:00

  • Differences between rheumatology attending physicians and training residents in the management of rheumatoid arthritis in Spain.

    abstract:OBJECTIVE:To evaluate the variability in the characteristics and management of rheumatoid arthritis (RA) patients between rheumatology attending physicians and training residents in Spain. METHODS:A retrospective medical record (MR) review was performed in a probabilistic sample of 1379 RA patients from 46 centres dis...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/03009740802055992

    authors: Lopez-Gonzalez R,Hernandez-Garcia C,Abasolo L,Morado I,Lajas C,Vadillo C,Pato E,Fernandez-Gutierrez B,Jover JA,Loza E,emAR Study Group.

    更新日期:2008-11-01 00:00:00

  • Teeth loss and the inflammation of teeth-supporting tissues in rheumatoid disease.

    abstract::To compare the state of dentition between rheumatoid and control patients, ortopanthomograms were taken of 126 rheumatoid and 119 control patients. This roenthenologic examination revealed a signficantly higher incidence of teeth loss among the rheumatoid patients than among the control patients. To determine whether ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747509095615

    authors: Malmström M,Calonius PE

    更新日期:1975-01-01 00:00:00

  • Predictive value of a multi-biomarker disease activity score for clinical remission and radiographic progression in patients with early rheumatoid arthritis: a post-hoc study of the OPERA trial.

    abstract:OBJECTIVES:Measurement of serum biomarkers at disease onset may improve prediction of disease course in patients with early rheumatoid arthritis (RA). We evaluated the multi-biomarker disease activity (MBDA) score and early changes in MBDA score for prediction of 28-joint Disease Activity Score based on C-reactive prot...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2018.1464206

    authors: Brahe CH,Østergaard M,Johansen JS,Defranoux N,Wang X,Bolce R,Sasso EH,Ørnbjerg LM,Hørslev-Petersen K,Stengaard-Pedersen K,Junker P,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Lottenburg

    更新日期:2019-01-01 00:00:00

  • The prevalence of rheumatoid arthritis in different geographical areas in sweden.

    abstract::In the general population of 39,418 persons within areas in the counties of Norrbotten (BD), Jämtland (Z), Skaraborg (R), Kristianstad west coast (LV), and Kristianstad east coast (L) in Sweden all the inhabitants over the age of seven (in Norrbotten over the age of 14) were investigated for the total number of cases ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165382

    authors: Hellgren L

    更新日期:1987-01-01 00:00:00

  • No effect of low power laser in lateral epicondylitis.

    abstract::Thirty-six patients with lateral epicondylitis of the elbow (19 women, 17 men, median age 48 yrs) were treated either with active laser or placebo, 18 patients in each group. The active laser was a GA-AL-AS 30 mW/830 nm low power laser (LPL). The study design was double blind and randomized. The treatment session cons...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009749409103726

    authors: Krasheninnikoff M,Ellitsgaard N,Rogvi-Hansen B,Zeuthen A,Harder K,Larsen R,Gaardbo H

    更新日期:1994-01-01 00:00:00

  • Exercises may be as efficient as subacromial decompression in patients with subacromial stage II impingement: 4-8-years' follow-up in a prospective, randomized study.

    abstract:OBJECTIVES:To compare the prognosis of subacromial impingement (SAI) stage II treated conservatively or with subacromial decompression. METHODS:A follow-up study after 4-8 years in a randomized controlled trial (RCT) with 90 adult cases with SAI treated in a Danish hospital from 1996 to 2000 with graded physiotherapy ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009740600556167

    authors: Haahr JP,Andersen JH

    更新日期:2006-05-01 00:00:00

  • Expression of the rheumatoid factor cross-reactive idiotype in JRA: association with disease onset subtype, disease activity and disease severity.

    abstract::We previously reported that approximately one-third of patients with juvenile rheumatoid arthritis (JRA) express high concentrations of antibodies marked by the rheumatoid factor cross reactive idiotype (RCRI) in their sera (6). In order to determine if an expression of RCRI is associated with certain clinical feature...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209095067

    authors: Ilowite NT,O'Reilly ME,Hatam L,Wedgwood JF,Bonagura VR

    更新日期:1992-01-01 00:00:00

  • Thrombotic microangiopathy in adult Still's disease.

    abstract::Adult Still's disease (ASD) is a rare systemic disorder characterized by fever, arthralgia, cutaneous rash, and lymphadenopathy, with high polymorphonuclear leucocytosis and low glycosylated ferritinaemia. Kidney involvement has been reported rarely. We present a patient with ASD who developed haemolytic uraemic syndr...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740510026689

    authors: Quéméneur T,Noel LH,Kyndt X,Droz D,Fleury D,Binaut R,Lemaitre V,Gobert P,Vanhille P

    更新日期:2005-09-01 00:00:00

  • The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.

    abstract::YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthriti...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950154257

    authors: Volck B,Ostergaard K,Johansen JS,Garbarsch C,Price PA

    更新日期:1999-01-01 00:00:00

  • Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis.

    abstract:OBJECTIVES:We aimed to investigate the possible effects of vimentin (Vim) and citrullinated Vim (cVim) on proliferation capacity, pro-inflammatory cytokine secretion, and the expression of peptidylarginine deiminase type 4 (PADI4) and receptor activator of nuclear factor kappa B ligand (RANKL) in cultured fibroblast-li...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2012.670263

    authors: Fan LY,He DY,Wang Q,Zong M,Zhang H,Yang L,Sun LS

    更新日期:2012-10-01 00:00:00

  • Interleukin-11 (IL-11) in aseptic loosening of total hip replacement (THR).

    abstract::The chronic inflammatory response to abrasion particles from total hip replacement (THR) is believed to cause osteolysis and to contribute to prosthetic loosening. The expression of interleukin-11(IL-11) and its major cellular sources in the interface and pseudocapsular tissues obtained from total hip revisions perfor...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749850154393

    authors: Xu JW,Li TF,Partsch G,Ceponis A,Santavirta S,Konttinen YT

    更新日期:1998-01-01 00:00:00

  • Combination therapy of cyclosporine A with methotrexate or hydroxychloroquine in refractory rheumatoid arthritis.

    abstract::We evaluated the efficacy and toxicity of cyclosporine A (CsA) in combination with methotrexate (MTX) or hydroxychloroquine (HCQ) in patients with refractory rheumatoid arthritis (RA). Fourteen patients with active RA who had failed to respond adequately to injectable MTX and 14 who had failed to respond to oral HCQ h...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.3109/03009749609082662

    authors: Salaffi F,Carotti M,Cervini C

    更新日期:1996-01-01 00:00:00

  • Healing of erosions in rheumatoid arthritis remains elusive: results with 24 months of the anabolic agent teriparatide.

    abstract::Objective: Erosion healing in rheumatoid arthritis (RA) is difficult to demonstrate. This extension study aimed to determine whether 2 years of teriparatide (TPTD) produces erosion healing. Method: Subjects in a previous 12 month randomized controlled trial of TPTD in RA were invited to receive 12 additional months of...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1772362

    authors: Duryea J,Gravallese EM,Wortman JR,Xu C,Lu B,Kay J,Solomon DH

    更新日期:2021-01-01 00:00:00

  • Sustained improvement of vascular endothelial function during anti-TNFalpha treatment in rheumatoid arthritis patients.

    abstract:OBJECTIVES:Vascular endothelial function and common carotid artery intima-medial thickness (CCA-IMT) are well-established surrogate markers for early atherosclerotic disease, which accounts for 30-40% of excess mortality in rheumatoid arthritis (RA) patients. Our aim was to investigate whether long-term treatment with ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740802363768

    authors: Sidiropoulos PI,Siakka P,Pagonidis K,Raptopoulou A,Kritikos H,Tsetis D,Boumpas DT

    更新日期:2009-01-01 00:00:00

  • Lack of corneal chrysiasis in rheumatoid arthritis patients undergoing oral gold therapy.

    abstract::Corneal chrysiasis is a common consequence of parenteral chrysotherapy in patients affected by rheumatoid arthritis. Concerning the factors and conditions that could be determinant for the gold accumulation in the cornea, there are contradictory opinions. Total or weekly gold dose and its accumulation quota, and the f...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748509165501

    authors: Mathieu A,Pala R,Carta S,Orzalesi N,Balestrieri A

    更新日期:1985-01-01 00:00:00

  • Antinuclear antibody screening in this new millennium: farewell to the microscope?

    abstract::ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime,...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162860

    authors: Nossent H,Rekvig OP

    更新日期:2001-01-01 00:00:00

  • Burden of rheumatoid arthritis in the Nordic region, 1990-2015: a comparative analysis using the Global Burden of Disease Study 2015.

    abstract:OBJECTIVE:To report mortality and disability due to rheumatoid arthritis (RA) in the Nordic region (Denmark, Finland, Greenland, Iceland, Norway, and Sweden) using data from the Global Burden of Disease Study (GBD) 2015. METHOD:Using the results of GBD 2015, we present rates and trends in prevalence, mortality, years ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2017.1314002

    authors: Kiadaliri AA,Kristensen LE,Englund M

    更新日期:2018-03-01 00:00:00

  • Spondyloarthritis: a strong predictor of early coronary artery bypass grafting.

    abstract:OBJECTIVES:The main aim of the study was to examine whether patients with spondyloarthritides underwent their first coronary artery bypass grafting (CABG) at a younger age than those without spondyloarthritides. METHODS:Patients who underwent their first CABG at the Feiring Heart Clinic during 2001-2005 were preoperat...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740701716868

    authors: Hollan I,Saatvedt K,Almdahl SM,Mikkelsen K,Moer R,Halvorsen P,Veel T,Førre OT

    更新日期:2008-01-01 00:00:00

  • Prevalence of rheumatoid arthritis in densely and thinly populated areas in sweden.

    abstract::The prevalence of rheumatoid arthritis in 1,287 persons living in densely populated areas and 1, 287 persons living in thinly populated areas, matched as to sex, age, occupation and geographical area, was compared. The patient material was obtained in an epidemiological survey of rheumatoid arthritis (ARA definition) ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165351

    authors: Hellgren L

    更新日期:1987-01-01 00:00:00

  • Giant cell arteritis. Clinical features and involvement of different organs.

    abstract::Sixty-eight patients with giant cell arteritis (GCA) are described. In 42, histological evidence of arteritis was recorded at biopsy of a temporal artery. Twenty-six patients were included according to clinical criteria. In 20 patients the onset of illness was associated with an infection. The first symptom was: in 30...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747809095645

    authors: Malmvall BE,Bengtsson BA

    更新日期:1978-01-01 00:00:00

  • The value of the diagnostic criteria in rheumatoid arthritis.

    abstract::The ARA and the New York diagnostic criteria for rheumatoid arthritis were studied in 411 patients with a recent inflammatory joint disease (100 with RA, 311 with other disease) in order to evaluate their value in distinguishing progressive rheumatoid arthritis from other joint diseases. Rheumatoid factor, symmetrical...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748309102003

    authors: Kaarela K,Hämeenkorpi R,Isomäki H

    更新日期:1983-01-01 00:00:00

  • T cell receptor (V beta) bias in the response of rheumatoid arthritis synovial fluid T cells to connective tissue antigens.

    abstract::T cell receptor (V beta) use in the response to type II collagen and cartilage proteoglycans was analysed in peripheral blood and synovial fluid T cells from RA patients. T cells from RA patients with an immune response to connective tissue antigens, and paired PB and SF samples were stimulated in vitro with type II c...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749709065676

    authors: Cuesta IA,Sud S,Song Z,Affholter JA,Karvonen RL,Fernández-Madrid F,Wooley PH

    更新日期:1997-01-01 00:00:00

  • Activation of the coagulation system in connective tissue diseases. A study of [125I] fibrinogen clearance.

    abstract::Fifty-one patients with different connective tissue diseases in either active or clinically inactive phase were studied to detect the incidence of chronic or subclinical consumption coagulopathy in these forms. Every patient received intravenously 20 mu Ci of [125I] fibrinogen and the clearance of the labeled fibrinog...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112361

    authors: Canesi BA,Banfi F,Rossi AF,Sinigaglia L

    更新日期:1980-01-01 00:00:00

  • The time of day that etidronate is ingested does not influence its therapeutic effect in osteoporosis.

    abstract::To investigate whether the therapeutic effect of etidronate is affected by the time of ingestion we have retrospectively studied 110 osteoporotic patients. They had been taking etidronate according to the manufacturer's instructions for a mean duration of 2.6 years either on waking (n=47), on retiring (n=47), or durin...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097400750001824

    authors: Cook GJ,Blake GM,Fogelman I

    更新日期:2000-01-01 00:00:00

  • Prevalence and significance of MEFV gene mutations in patients with sarcoidosis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2015.1092580

    authors: Sever F,Kobak S,Goksel Ö,Goksel T,Orman M,Berdeli A

    更新日期:2016-01-01 00:00:00

  • An assessment of the new "SCORE" index as a predictor of osteoporosis in women.

    abstract:BACKGROUND:The study was done to determine whether the new SCORE (Simple Calculated Osteoporosis Risk Estimation) index might reduce the utilization of bone mineral density (BMD) measurement. METHODS:989 consecutive patients who were referred by a range of physicians for BMD assessments at one of two clinics had a SCO...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401750065300

    authors: Russell AS,Morrison RT

    更新日期:2001-01-01 00:00:00