Sudden death and Wegener's granulomatosis of the pituitary.

Abstract:

:Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnormal pituitary function tests in the setting of active systemic vasculitis. However, histology-proven involvement of the pituitary by WG has not been reported so far. We report a case of WG with histology-proven granulomatous necrotizing inflammation of the pituitary and hypothalamo-pituitary stalk, disclosed at autopsy after the patient had died suddenly and unexpectedly in his sleep. In a setting of histology-proven WG, these findings were regarded as a pituitary manifestation of the disorder. A distinct cause of death could not be found, hence we speculate that hypothalamo-pituitary inflammation due to WG may have caused the sudden death in this patient.

journal_name

Scand J Rheumatol

authors

Woywodt A,Knoblauch H,Kettritz R,Schneider W,Göbel U

doi

10.1080/030097400750041433

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

264-6

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

29

pub_type

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