Abstract：
:The evidence base for treatment of systemic vasculitis is reviewed in this article. Accurate diagnosis and evaluation of disease status is crucial to the appropriate management of these cases and disease status should be employed as a means of staging so that appropriate therapy can be offered tailored to the individual requirements of each case. Large vessel vasculitides are almost exclusively managed with corticosteroids. Small vessel vasculitis with internal organ involvement usually requires more aggressive immuno-suppression; by contrast, small vessel vasculitis without internal organ involvement rarely requires intervention. Despite our current efforts, the long-term morbidity of patients with systemic vasculitis remains high. We need better therapeutic strategies in order to limit or control disease rapidly and thereby prevent the accumulation of subsequent damage. Large-scale randomised trials comparing different therapeutic strategies offer the only hope of establishing a firmer evidence base for the optimal management of these diseases.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Luqmani RAdoi
10.1080/030097400750041334keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
211-5issue
4eissn
0300-9742issn
1502-7732journal_volume
29pub_type
社论,评审abstract：:It is thought that glucocorticosteroids impair the clearance of immune complexes by the mononuclear phagocyte system (MPS). We studied the effect of a five day course of prednisone (1 mg/kg body weight per day) on MPS function in 10 healthy volunteers, using soluble radiolabeled aggregates of human immunoglobulin G as...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749209095084
更新日期：1992-01-01 00:00:00
abstract：:No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097402317255372
更新日期：2002-01-01 00:00:00
abstract：:Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498440877
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:In 2010, the American College of Rheumatology (ACR) proposed new criteria for the diagnosis of fibromyalgia (FM) in the context of objections to components of the criteria of 1990. The new criteria consider the Widespread Pain Index (WPI) and the Symptom Severity Score (SSS). This study evaluated the implica...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1010103
更新日期：2015-01-01 00:00:00
abstract：:Reports of the rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults are reviewed in order to determine the most common presentations and which individuals are at risk for rheumatic disease. Relevant English-language articles were identified through a Medline search and from bibliographies...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,评审
doi：10.3109/03009749409103055
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:The present randomized controlled trial compared arthrocentesis of the effusive knee followed by corticosteroid injection performed by the conventional anatomic landmark palpation-guided technique to the same procedure performed with ultrasound (US) needle guidance. METHODS:Sixty-four palpably effusive knees...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.3109/03009742.2011.599071
更新日期：2012-02-01 00:00:00
abstract：:The aim of the present study was to relate postural control, as measured on a quantitative test battery as standing balance on an AMTI force platform, to results of muscle function of the lower extremities, aerobic capacity, disease characteristics, attitudes revealing anxiety, and demographic variables in patients wi...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749209099245
更新日期：1992-01-01 00:00:00
abstract：:YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthriti...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009749950154257
更新日期：1999-01-01 00:00:00
abstract：:The right knee of adult rabbits was immobilized in extension for 5 weeks. The rabbits were then allowed to move freely for 8 weeks. Some rabbits were given 100 mg of ibuprofen (Brufen) daily per os during the immobilization and remobilization periods. The controls were not given any drug. The development of the thickn...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748009098145
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:To determine if calprotectin is predictive for outcome in patients with rheumatoid arthritis (RA). METHODS:Fifty six RA in-patients with variable disease duration were prospectively followed for five years. Clinical and laboratory data were collected to assess disease activity. Health Assessment Questionnair...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097402320817077
更新日期：2002-01-01 00:00:00
abstract：:A technique for assessing the overall consequences of disease is introduced, comprising a Swedish version of a behaviour-based measure, the Sickness Impact Profile (SIP). Measurement characteristics of the profile are defined in an epidemiological study of 147 women with rheumatic disorders. The drop-out rate was 7.5%...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748609102088
更新日期：1986-01-01 00:00:00
abstract：:The intestinal permeability to polyethyleneglycols (PEGs) of varying size in patients with rheumatoid arthritis has been investigated. Permeability was determined by measuring the 6-hour urinary recovery of different-sized PEGs after oral intake of PEG 400, PEG 1000, or PEG 3000. Patients with rheumatoid arthritis exc...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748309102897
更新日期：1983-01-01 00:00:00
abstract：:Immobilization of a rabbit leg in extension results in the early development of an aseptic inflammation, synovial effusion and stiffening, and subsequent osteoarthritis of the knee. To study the pathogenesis of this experimental osteoarthritis, the hydrostatic pressures were measured in the knee, and distal metaphysis...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748809098756
更新日期：1988-01-01 00:00:00
abstract：:The associations between the lumbar and femoral bone mineral and several body constitutional, lifestyle, and disease related variables were studied in 111 children with juvenile chronic arthritis (JCA) by factor and multiple linear regression analyses. In addition to the measurement of bone mineral density (BMD), bone...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009749950155733
更新日期：1999-01-01 00:00:00
abstract：:Dorland's Illustrated Medical Dictionary gives the following definition of dactylitis (deltaalphachitauupsilonlambdaomicronsigma = digit): 'inflammation of a finger or toe'. Although any inflammatory process involving the fingers or toes may be called dactylitis, the term has entered in current use only in some well-d...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,评审
doi：10.1080/03009740600906677
更新日期：2006-09-01 00:00:00
abstract：:The subclass distribution of IgG and IgA plasma cells, and in IgG and IgA rheumatoid factor (RF) producing cells was studied in sections of synovial tissue from seropositive RA and various types of seronegative arthritis, including ankylosing spondylitis, psoriatic arthritis, and Reiter's syndrome. The study was perfo...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749009096788
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:To apply the Rasch model to the Norwegian version of the Arthritis Self-Efficacy Scale (ASES). METHOD:The ASES was included in a self-administered questionnaire sent to 224 patients attending one of three rehabilitation centres for rheumatic diseases in Norway in 2009. The fit of the ASES to the Rasch model...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2016.1155644
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production. METHODS:We genotyped 111 unrelated German Caucasian patients with pSS and...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740801910353
更新日期：2008-07-01 00:00:00
abstract：:Objective: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease. Studies suggest that pro-inflammatory cytokines may be attenuated by the vagus nerve through the cholinergic anti-inflammatory pathway. We aimed to evaluate the anti-inflammatory effects of short-term transcutaneous non-invasive vagus...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2020.1764617
更新日期：2021-01-01 00:00:00
abstract：:Fifty-one patients with different connective tissue diseases in either active or clinically inactive phase were studied to detect the incidence of chronic or subclinical consumption coagulopathy in these forms. Every patient received intravenously 20 mu Ci of [125I] fibrinogen and the clearance of the labeled fibrinog...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748009112361
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the gustatory and olfactory functions of patients with rheumatoid arthritis (RA) compared to sex- and age-matched healthy subjects and to investigate a potential relationship between disease activity [using the 28-joint Disease Activity Score (DAS28)] and chemosensory capacity. Furthermore, to di...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2010.517547
更新日期：2011-05-01 00:00:00
abstract：:Fifty consecutive patients with RA and clinical wrist synovitis were randomly allocated to either receive an injection of glucocorticoid into the radiocarpal joint or have the same amount of drug divided into the radiocarpal and midcarpal joints. Inferior radioulnar joint synovitis was treated with extra steroid injec...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.1080/030097401753180336
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVES:To determine which variables at baseline are predictive for the development of rheumatoid arthritis (RA) from palindromic rheumatism (PR) in a Japanese population. METHODS:Anti-cyclic citrullinated peptide (anti-CCP) antibodies, joint involvement pattern, genotypes of HLA-DRB1, peptidylarginine deiminase (P...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009741003604534
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD:A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. On...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009740903270623
更新日期：2010-03-01 00:00:00
abstract：:A study of 113 knees of 72 patients treated with intra-articular injection of osmic acid for chronic exudative synovitis caused by various rheumatic diseases is reported. Certain cases presented abnormal radiological opacities, statistically more frequent after the injection of 200 mg than after 100 mg of osmic acid (...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:A controlled cross over study on the effect of fasting on cyclic nucleotide and catecholamine excretion was carried out in 12 female RA patients. They were hospitalized during a control and fasting period. The fasting period started with 3 days of habituation to hospital conditions, followed by 7 days of total fasting...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/03009748309102906
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To determine whether high-frequency ultrasound (US) yielding separate assessments of intima and media thickness gives additional information about the vascular morphology compared with the total common carotid artery intima-media thickness (CCA-IMT). METHODS:Using a 22 MHz US instrument, we determined the ne...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2011.556146
更新日期：2011-01-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and serositis. Typical attacks of FMF last 3 to 5 days. Fever and myalgia are not always improved by colchicine therapy and sometimes require steroid therapy. We present two cases of severe prolonged febrile myalgia where steroid therapy...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097400447615
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the effects of physiologically relevant concentrations of multimeric adiponectin isoforms and leptin on the function of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). METHOD:FLS, isolated from the synovial tissue of 21 RA patients, were stimulated for 24 h with ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1025833
更新日期：2015-01-01 00:00:00
abstract：:Psychological and emotional status was assessed in 36 patients with systemic lupus erythematosus (SLE) with the General Health Questionnaire-30 (GHQ-30) and Minnesota Multiphasic Personality Inventory (MMPI) questionnaires. The two tests were found to measure different aspects of psychological functioning. More than 5...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498442226
更新日期：1998-01-01 00:00:00
