The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome.

Abstract:

OBJECTIVE:To determine the impact of a broad spectrum of different polymorphisms within the interleukin-10 (IL-10) promoter gene on disease susceptibility to primary Sjogren's syndrome (pSS), clinical manifestations, and autoantibody production. METHODS:We genotyped 111 unrelated German Caucasian patients with pSS and 145 healthy controls for the single nucleotide polymorphisms (SNPs) at positions -2849, -2776, -2769, -2763, -1349, -1082, -851, -819, -657, and -592 and for the microsatellites IL10.R and IL10.G. Allele and haplotype distributions were compared between patients and controls and between subgroups of patients with different clinical and laboratory findings. RESULTS:We found no significant differences in the allele or haplotype frequencies between pSS patients and healthy controls. After Bonferroni correction we found a significant association of the ACC haplotype (at the -1082, -819, and -592 loci) with immunoglobulin (Ig)A antibodies to anti-alpha-fodrin. CONCLUSION:Overall we found no associations of IL-10 promoter polymorphisms with the susceptibility to pSS in our cohort. The finding that the production of IgA anti-alpha-fodrin antibodies is associated with polymorphisms within the IL-10 promoter region suggests a genetic contribution to the generation of these antibodies.

journal_name

Scand J Rheumatol

authors

Willeke P,Gaubitz M,Schotte H,Becker H,Domschke W,Schlüter B

doi

10.1080/03009740801910353

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

293-9

issue

4

eissn

0300-9742

issn

1502-7732

pii

794852372

journal_volume

37

pub_type

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