Effect of indomethacin and naproxen on the metabolism of collagen in adjuvant-induced arthritis.

Abstract:

:The effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [3H]-proline, both the specific and total radioactivity of [3H]-hydroxyproline being determined in skin collagen fractions and in urine. It was found that collagen synthesis and conversion of soluble to insoluble collagen are diminished, accompanied by an increased collagen degradation in untreated arthritic animals. Administration of indomethacin and naproxen to arthritic animals accelerated the synthesis of collagen and conversion soluble to insoluble collagen and inhibited the catabolism of collagen.

journal_name

Scand J Rheumatol

authors

Arumugham R,Bose SM

doi

10.3109/03009748109095291

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

161-7

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

10

pub_type

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