Virus-Induced Specific Cell Surface Antigen(s) on Mouse Adenovirus-Infected Cells.

Abstract:

:A virus-specific cell surface antigen(s) was detected on mouse adenovirus-infected cells by the immunofluorescent antibody technique. It was demonstrated in infected cells regardless of the mouse strain or animal species used. It became detectable on the cell surface about 6 h postinfection and was demonstrated in 90% of infected cells at 24 to 36 h postinfection. On the other hand, intracellular capsid antigens became detectable by the immunofluorescent antibody technique at about 24 h postinfection. Since it was also detected on virus-infected cells treated with 5'-fluorodeoxyuridine to block viral deoxyribonucleic acid synthesis, it was synthesized at the early stage of infection and may not be a virus structural component. The relationship between this serologically detectable cell surface antigen(s) and cell-mediated immune response to virus infections is discussed.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Inada T,Uetake H

doi

10.1128/IAI.18.1.41-45.1977

keywords:

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

41-5

issue

1

eissn

0019-9567

issn

1098-5522

journal_volume

18

pub_type

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