Cellular changes in rat parathyroids provoked by progesterone and testosterone.

Abstract:

:Male rats kept on a standard diet were treated either with progesterone or testosterone by a single intramuscular injection of preparations which are slowly absorbed and metabolized. The rats were anaesthetized 24 h after application of the hormones, perfused with glutaraldehyde, and the parathyroid glands prepared for electron microscopy. Morphometric analysis revealed that both progesterone and testosterone provoked (1) an increment in nuclear and cell volume and a concomitant increment in cell surface area, and (2) an increment in surface area of rough endoplasmic reticulum by 42% and 49%, and of the Golgi complex by 85% and 63%, respectively. Previously, we had found that oestradiol treatment led to a similar response in parathyroid cells. The conclusion is thus drawn that male and female sex hormones induce membrane synthesis resulting in an enhanced capacity for parathyroid hormone secretion since RER and Golgi complex are concerned with this secretion. It is considered probable that sex hormones have the ability fundamentally to modulate secretory activity in parathyroid cells.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Brunner M,Schraner EM,Wild P

doi

10.1007/BF00318797

keywords:

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

283-6

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

268

pub_type

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