Abstract：
:The effect of hypothyroidism, induced by 4-propyl-2-thiouracil, on muscle satellite cells in vivo and in vitro, and on postnatal muscle fiber development in the soleus muscle of rats during the first 40 days of postnatal life was analyzed. The proliferative activity of satellite cells was determined by means of bromodeoxyuridine incorporation. Creatine kinase activity was used as a marker for differentiation. In vivo, hypothyroidism resulted in smaller fibers in which the amount of sarcoplasm remained in balance with the number of myonuclei. The in vivo labeling data of satellite cells did not indicate a decreased proliferative activity, but the in vitro experiments showed that the hypothyroid rat muscles contained fewer satellite cells that were less active in proliferation and differentiation at the start of culture. Despite this, the bromodeoxyuridine signal increased in time at a similar rate as that in control cultures. From this and because the cells resembled control cells in their response to bFGF, we conclude that hypothyroid satellite cells remain responsive to proliferation stimuli. However, in hypothyroid cultures, the activity of creatine kinase is lower, even at longer culture times. We therefore conclude that hypothyroid status affects muscle precursor cells mainly by depressing their ability to differentiate and fuse with existing myofibers.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Jacobs SC,Bär PR,Bootsma ALdoi
10.1007/s004410050682subject
Has Abstractpub_date
1996-10-01 00:00:00pages
137-44issue
1eissn
0302-766Xissn
1432-0878journal_volume
286pub_type
杂志文章abstract：:In the present study, we characterized intra-epithelial leukocytes in the digestive tract of chickens during postnatal development. Their phenotype was characterized by monoclonal antibodies in cryostat sections and the numbers of the different cell-types were counted in the epithelium of the esophagus, proventriculus...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318748
更新日期：1993-11-01 00:00:00
abstract：:Recent studies demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in primary sensory neurons (PSNs). The present study was undertaken to reveal the target-specific expression of the InsR and its co-localizati...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2868-0
更新日期：2018-11-01 00:00:00
abstract：:The antennal lobe is the primary processing center for olfactory information in insects. To understand further the neural circuitry of this brain area, we have investigated the distribution of gamma-aminobutyric acid (GABA) and its colocalization with neuropeptides in the antennal lobe of the noctuid moth Heliothis vi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0744-z
更新日期：2009-03-01 00:00:00
abstract：:During tooth development, the inner and outer enamel epithelia fuse by mitotic activity to produce a bilayered epithelial sheath termed Hertwig's epithelial root sheath (HERS). The epithelial rests of Malassez (ERM) are the developmental residues of HERS and remain in the adult periodontal ligament (PDL). Although the...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-1076-3
更新日期：2010-12-01 00:00:00
abstract：:The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel responsible for mobilizing stored Ca2+. Three different receptor types have been molecularly cloned, and their genes have been classified into a family. The gene for the type 1 receptor (IP3R1) is predominantly expressed in cereb...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00307790
更新日期：1995-05-01 00:00:00
abstract：:Nematocysts are characteristic organelles of the phylum Cnidaria. The free-living Platyhelminth Microstomum lineare preys on Hydra oligactis and sequesters nematocysts. All nematocyst types become phagocytosed without adherent cytoplasm by intestinal cnidophagocytes. Desmoneme and isorhiza nematocysts disappear within...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-019-03149-w
更新日期：2020-01-01 00:00:00
abstract：:The distribution of nerve fibres in the mucosa of the nasal septum of the rat was investigated by means of transmission electron microscopy on transverse and tangential ultrathin sections. Near the basement membrane of respiratory and squamous epithelium, a rather dense network of unmyelinated nerve fibres occurs. Som...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318751
更新日期：1993-11-01 00:00:00
abstract：:Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this ...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-013-1750-3
更新日期：2014-01-01 00:00:00
abstract：:The development of the egg envelope and its incorporation into the larval cuticle of the polychaete Phragmatopoma lapidosa, was studied by correlative scanning and transmission electron microscopy. The mature egg possesses an envelope composed of five zones including an outer granular zone formed by the tips of the eg...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225530
更新日期：1978-01-17 00:00:00
abstract：:In model experiments with the use of horseradish peroxidase (HRP), two pathways of transport of substances to the adenohypophysis were studied, as well as the distribution of the tracer in the latter organ. The first pathway allows the tracer to penetrate from the intercellular milieu of the median eminence below the ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214248
更新日期：1984-01-01 00:00:00
abstract：:Myogenesis is a complex process in which committed myogenic cells differentiate and fuse into myotubes that mature into the muscle fibres of adult organisms. This process is initiated by a cascade of myogenic regulatory factors expressed upon entry of the cells into the myogenic differentiation programme. However, ext...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1364-1
更新日期：2012-06-01 00:00:00
abstract：:Sections of glutaraldehyde-OsO4-fixed, plastic-embedded rat incisor enamel were left untreated, stained, decalcified (1% formic acid in 10% sodium citrate), or decalcified-stained. The presence of apatite crystals was monitored with electron diffraction. After brief decalcification and staining, apatite crystals and m...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215908
更新日期：1986-01-01 00:00:00
abstract：:Calbindin is a calcium-binding protein, commonly found in certain subpopulations of the enteric nervous system in mammals. Recently, calbindin-immunoreactive enteric neurons have also been demonstrated in shorthorn sculpin (Myoxocephalus scorpius). In the present study, calbindin immunoreactivity has been investigated...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1135-4
更新日期：2011-04-01 00:00:00
abstract：:The ultrastructure of corpora lutea obtained during the preimplantation implantation and early post-implantation periods has been studied in 20 western spotted skunks. Fine structure of granulosa lutein cells was correlated with progesterone levels. The corpus luteum of the prolonged (7 month) preimplantaion period co...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218972
更新日期：1975-12-02 00:00:00
abstract：:Growth hormone, prolactin and somatostatin-like immunoreactivities were demonstrated in the brains of larval, young adult (parasitic) and upstream migrant adult sea lampreys, Petromyzon marinus, by means of immunoperoxidase techniques. Growth hormone (GH) and prolactin (PRL) were observed within separate perikarya in ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218994
更新日期：1986-01-01 00:00:00
abstract：:Whether environmental exposure to bisphenol A (BPA) may induce reproductive disorders is still controversial but certain studies have reported that BPA may cause meiotic abnormalities in C. elegans and female mice. However, little is known about the effect of BPA on meiosis in adult males. To determine whether BPA exp...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1723-6
更新日期：2014-01-01 00:00:00
abstract：:Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the adult brain. Notch functions greatly depend on careful regulation and cross-talk with other regulatory mechanisms. Deregulation of Notc...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-017-2641-9
更新日期：2018-01-01 00:00:00
abstract：:Sites of synthesis and release patterns of crustacean hyperglycaemic hormone precursor-related peptide (CPRP) were investigated with those of crustacean hyperglycaemic hormone (cHH), in order to determine whether this precursor-related peptide satisfies certain criteria necessary for its definition as a secretable, ci...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-001-0469-8
更新日期：2002-01-01 00:00:00
abstract：:Differentiated nongranulated (folliculo-stellate) cells were observed in the centre and periphery of the cords of cells in the pars distalis of the adult tammar wallaby (Macropus eugenii). The nongranulated cells formed follicles containing a small lumen: the cell apices were joined by junctional complexes including z...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210898
更新日期：1982-01-01 00:00:00
abstract：:Injection of wheat-germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the superior cervical ganglion (SCG) of the rat results in accumulation of WGA-HRP in sympathetic postganglionic neurons in the contralateral SCG. The sympathetic pathways involved and the mechanism underlying the labeling were investig...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00327745
更新日期：1990-10-01 00:00:00
abstract：:In the present study, the effect of LHRH on the process of protein and/or peptide secretion characterized by the formation of granular vesicles has been studied by means of an in vitro system in the pinealocytes of three different species of rodents. LHRH has a strong influence on the activity of this process. However...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216426
更新日期：1983-01-01 00:00:00
abstract：:Loss of wild-type p53 activity is thought to be a major predictor of failure to respond to radiotherapy and chemotherapy in various human cancers. This assumption is largely based on some cell-death studies in p53-knockout mice and on correlations of p53 status assessed by immunochemistry or single-strand conformation...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s004410051072
更新日期：1998-06-01 00:00:00
abstract：:New genome-editing approaches, such as the CRISPR/Cas system, have opened up great opportunities to insert or delete genes at targeted loci and have revolutionized genetics in model organisms like the zebrafish. The Cre-loxp recombination system is widely used to activate or inactivate genes with high spatial and temp...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2798-x
更新日期：2018-04-01 00:00:00
abstract：:Guanosine triphosphatase (GTPase) activity was studied histo- and cytochemically in the rod outer segments of the rat retina by means of a newly developed method. Differences in the distribution pattern of the enzyme activity exist within the outer segment: the activity is more intense at the tip of the rod outer segm...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217416
更新日期：1983-01-01 00:00:00
abstract：:Neural lobes of control and "Jimpy" mice were examined electron microscopically. The ultrastructure and incidence of pituicytes was examined following reports of reductions in astrocyte and oligodendrocyte populations in areas of the CNS of Jimpy mice. The failure to demonstrate any modification of structure or number...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220162
更新日期：1976-03-05 00:00:00
abstract：:Caveolae or membrane vesicles are commonly observed in smooth and skeletal muscle as well as in working heart muscle. Using sections of fixed tissue and replicas of freeze-cleaved material, we show in this study that caveolae are also very numerous in sinus node cells of the rabbit, and to a lesser degree, in the atri...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234869
更新日期：1980-01-01 00:00:00
abstract：:Two types of horizontal cells, H1 and H2, were classified using the Golgi technique on flat mounts of the retina of the frog. Cell type H1 possesses rather short, thick dendrites; the diameter of its dendritic field ranges from 40-90 micrometers. H2-cell displays long and thin dendrites; the diameter of its dendritic ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216747
更新日期：1981-01-01 00:00:00
abstract：:Identified dorsal unpaired median (DUM) neurones of the locust Locusta migratoria were stained intracellularly with large amounts of cobalt to reveal their extensive peripheral branching patterns. Two neurones of the suboesophageal ganglion were studied as well as several neurones of thoracic ganglia. The peripheral b...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050970
更新日期：1997-12-01 00:00:00
abstract：:The ultrastructural immunohistochemical localization of gamma aminobutyric acid (GABA) and its regulating enzymes, L-glutamate decarboxylase (GAD) and gamma aminobutyrate-alpha-ketoglutarate transaminase, was determined utilizing an immunogold post-embedding protocol in pancreatic exocrine tissue. Within the acinar ce...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213841
更新日期：1988-04-01 00:00:00
abstract：:The juxtaglomerular apparatus (JGA) in the rabbit kidney was examined by transmission electron microscopy and by freeze fracturing. It was found, that the Goormaghtigh cells of the JGA are extensively coupled with the mesangial cells within the glomerular tuft by gap junctions. A broad band of gap junctions starting w...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225537
更新日期：1978-01-17 00:00:00
