Is the unilateral lesion of the left substantia nigra pars compacta sufficient to induce working memory impairment in rats?

abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...

journal_title：Neurobiology of learning and memory

authors： Foilb AR,Flyer-Adams JG,Maier SF,Christianson JP

更新日期：2016-10-01 00:00:00

abstract：:Performing sequences of movements is a ubiquitous skill that involves dopamine transmission. However, it is unclear which components of the dopamine system contribute to which aspects of motor sequence learning. Here we used a genetic approach to investigate the relationship between different components of the dopamin...

journal_title：Neurobiology of learning and memory

authors： Baetu I,Burns NR,Urry K,Barbante GG,Pitcher JB

更新日期：2015-11-01 00:00:00

abstract：:Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mu...

journal_title：Neurobiology of learning and memory

authors： Kerner-Rossi M,Gulinello M,Walkley S,Dobrenis K

更新日期：2019-11-01 00:00:00

abstract：:The present experiment examined whether posttraining noradrenergic activity within the basolateral complex of the amygdala (BLA) is required for mediating the facilitating effects of acutely administered glucocorticoids on memory for auditory-cue classical fear conditioning. Male Sprague-Dawley rats received five pair...

journal_title：Neurobiology of learning and memory

authors： Roozendaal B,Hui GK,Hui IR,Berlau DJ,McGaugh JL,Weinberger NM

更新日期：2006-11-01 00:00:00

abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

journal_title：Neurobiology of learning and memory

authors： Collins BE,Sweatt JD,Greer CB

更新日期：2019-05-01 00:00:00

abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

journal_title：Neurobiology of learning and memory

authors： Kuhlmann S,Kirschbaum C,Wolf OT

更新日期：2005-03-01 00:00:00

abstract：:Renewal, or reinstatement, of responding to food cues after extinction may explain the inability to resist palatable foods and change maladaptive eating habits. Previously, we found sex differences in context-dependent renewal of extinguished Pavlovian conditioned responding to food cues. Context-induced renewal invol...

journal_title：Neurobiology of learning and memory

authors： Anderson LC,Petrovich GD

更新日期：2017-03-01 00:00:00

abstract：:Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-mo...

journal_title：Neurobiology of learning and memory

authors： Da Cunha C,Roozendaal B,Vazdarjanova A,McGaugh JL

更新日期：1999-07-01 00:00:00

abstract：:The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng)....

journal_title：Neurobiology of learning and memory

authors： Stoehr JD,Mobley SL,Roice D,Brooks R,Baker LM,Wiley RG,Wenk GL

更新日期：1997-05-01 00:00:00

abstract：:The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) affects numerous behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major psychiatric disorders and may lead to widespread abuse. The dorsal raphe nucleus (DRN) in the midbrain provides a majority of 5-HT for the forebrain. T...

journal_title：Neurobiology of learning and memory

authors： Luo M,Li Y,Zhong W

更新日期：2016-11-01 00:00:00

abstract：:Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear conditioning, particularly in the expression of fear to poor predictors ...

journal_title：Neurobiology of learning and memory

authors： Ressler RL,Goode TD,Evemy C,Maren S

更新日期：2020-10-01 00:00:00

abstract：:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after traini...

journal_title：Neurobiology of learning and memory

authors： Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CA

更新日期：2002-09-01 00:00:00

abstract：:Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...

journal_title：Neurobiology of learning and memory

authors： Houlton J,Barwick D,Clarkson AN

更新日期：2021-01-01 00:00:00

abstract：:Most long-term memories are forgotten, becoming progressively less likely to be recalled. Still, some memory fragments may persist, as savings memory (easier relearning) can be detected long after recall has become impossible. What happens to a memory trace during forgetting that makes it inaccessible for recall and y...

journal_title：Neurobiology of learning and memory

authors： Patel U,Perez L,Farrell S,Steck D,Jacob A,Rosiles T,Krause E,Nguyen M,Calin-Jageman RJ,Calin-Jageman IE

更新日期：2018-11-01 00:00:00

abstract：:Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Here we show that if Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, which at either site alone are insuff...

journal_title：Neurobiology of learning and memory

authors： Sherff CM,Carew TJ

更新日期：2002-11-01 00:00:00

abstract：:Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...

journal_title：Neurobiology of learning and memory

authors： Tai CT,Cassaday HJ,Feldon J,Rawlins JN

更新日期：1995-07-01 00:00:00

abstract：:Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/micro...

journal_title：Neurobiology of learning and memory

authors： Edeline JM,Hars B,Hennevin E,Cotillon N

更新日期：2002-07-01 00:00:00

abstract：:Memories for daily events require that individuals integrate initial fragile traces of events over time. Recent evidence suggests that reward anticipation enhances memory performance and amplifies frontal theta activity for remembered items vs. forgotten items. However, little is known about how incidental rewards aft...

journal_title：Neurobiology of learning and memory

authors： Pu M,Yu R

更新日期：2019-02-01 00:00:00

abstract：:Brief physical exercise enhances memories for neutral events, and recently has been shown to modulate fear learning in animals. To date there is no evidence pertaining to the impact of exercise on emotional memories in humans. Accordingly, this study investigated the role of brief exercise in the development of emotio...

journal_title：Neurobiology of learning and memory

authors： Keyan D,Bryant RA

更新日期：2017-05-01 00:00:00

abstract：:Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia i...

journal_title：Neurobiology of learning and memory

authors： Grau-Perales AB,Levy ERJ,Fenton AA,Gallo M

更新日期：2019-01-01 00:00:00

abstract：:This study was undertaken to verify the effects of chronic stress and lithium treatments on the hippocampal Na+,K(+)-ATPase activity of rats, as well as to investigate the effects of stress interruption and post-stress lithium treatment on this enzyme activity and on spatial memory. Two experiments were carried out; i...

journal_title：Neurobiology of learning and memory

authors： de Vasconcellos AP,Zugno AI,Dos Santos AH,Nietto FB,Crema LM,Gonçalves M,Franzon R,de Souza Wyse AT,da Rocha ER,Dalmaz C

更新日期：2005-09-01 00:00:00

abstract：:Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor(6) (5-HT(6)) improve memory and reverse amnesia although the mechanisms involved are poorly understood. Hence, in this paper RT-PCR was used to evaluate changes in mRNA expression of 5-HT(6) receptor in trained and untrained ra...

journal_title：Neurobiology of learning and memory

authors： Huerta-Rivas A,Pérez-García G,González-Espinosa C,Meneses A

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...

journal_title：Neurobiology of learning and memory

authors： Alvarenga TA,Patti CL,Andersen ML,Silva RH,Calzavara MB,Lopez GB,Frussa-Filho R,Tufik S

更新日期：2008-11-01 00:00:00

abstract：:Mounting evidence suggests that long-lasting, protein synthesis-dependent changes in synaptic strength accompany both the initial acquisition and subsequent recall of specific memories. Within brain areas thought to be important for learning and memory, including the hippocampus, learning-related plasticity is likely ...

journal_title：Neurobiology of learning and memory

authors： Chia C,Otto T

更新日期：2013-11-01 00:00:00

abstract：:The healthy aging process affects the ability to learn and remember new facts and tasks. Prior work has shown that motor learning can be adversely affected by non-motor deficits, such as time. Here we investigated how age, and a dual task influence the learning and forgetting of a new walking pattern. We studied healt...

journal_title：Neurobiology of learning and memory

authors： Malone LA,Bastian AJ

更新日期：2016-02-01 00:00:00

abstract：:Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as 'incubation of craving'. As adolescence...

journal_title：Neurobiology of learning and memory

authors： Madsen HB,Zbukvic IC,Luikinga SJ,Lawrence AJ,Kim JH

更新日期：2017-09-01 00:00:00

abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

journal_title：Neurobiology of learning and memory

authors： Stilling RM,Fischer A

更新日期：2011-07-01 00:00:00

abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

journal_title：Neurobiology of learning and memory

authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

更新日期：2018-11-01 00:00:00

abstract：:New neurons are continually produced in the adult mammalian brain from progenitor cells located in specific brain regions, including the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. We hypothesized that neurogenesis occurs in the canine brain and is reduced with age. We examined neurogenesis in the ...

journal_title：Neurobiology of learning and memory

authors： Siwak-Tapp CT,Head E,Muggenburg BA,Milgram NW,Cotman CW

更新日期：2007-09-01 00:00:00

abstract：:We have previously reported that extinction of escape behavior in the water maze due to the removal of the platform coincided with the development of behavioral "despair" in aged and adult rats, as assessed by immobility. The present study examines further predictions derived from the hypothesis that the withholding o...

journal_title：Neurobiology of learning and memory

authors： Schulz D,Huston JP,Buddenberg T,Topic B

更新日期：2007-03-01 00:00:00