The role of histone acetylation in age-associated memory impairment and Alzheimer's disease.

abstract：:Taste aversion learning is induced through two different behavioral procedures: a short-term or concurrent (two-daily flavors) and a long-term or sequential (one-daily flavor) procedure. For the concurrent group of animals, two gustatory/olfactory stimuli are presented separately but at the same time on a daily basis....

journal_title：Neurobiology of learning and memory

authors： Mediavilla C,Molina F,Puerto A

更新日期：2001-09-01 00:00:00

abstract：:Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-кB), which are present before the neuronal activity induced by training. It was proposed t...

journal_title：Neurobiology of learning and memory

authors： Zalcman G,Federman N,de la Fuente V,Romano A

更新日期：2015-03-01 00:00:00

abstract：:Most models of human and animal learning assume that learning is proportional to the discrepancy between a delivered outcome and the outcome predicted by all cues present during that trial (i.e., total error across a stimulus compound). This total error reduction (TER) view has been implemented in connectionist and ar...

journal_title：Neurobiology of learning and memory

authors： Witnauer JE,Urcelay GP,Miller RR

更新日期：2014-02-01 00:00:00

abstract：:This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual ...

journal_title：Neurobiology of learning and memory

authors： Abrari K,Rashidy-Pour A,Semnanian S,Fathollahi Y,Jadid M

更新日期：2009-03-01 00:00:00

abstract：:Drug abuse, overeating, and smoking are all examples of instrumental behaviors that often involve chains or sequences of behavior. A behavior chain is minimally composed of a procurement response that is required in order for a subsequent consumption response to be reinforced. Despite the translational importance of b...

journal_title：Neurobiology of learning and memory

authors： Thrailkill EA,Bouton ME

更新日期：2016-09-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:Individual differences in regulation of fear and extinction memory play significant roles in the aetiology development of post-traumatic stress disorder (PTSD). Previous animal based studies showed that the activity of β-adrenergic receptors (β-ARs) are involved in memory modulation. However in humans it is not clear ...

journal_title：Neurobiology of learning and memory

authors： Shi L,Chen SJ,Deng JH,Que JY,Lin X,Sun Y,Bao YP,Shi J,Lu L

更新日期：2018-12-01 00:00:00

abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

journal_title：Neurobiology of learning and memory

authors： Collins BE,Sweatt JD,Greer CB

更新日期：2019-05-01 00:00:00

abstract：:This article argues both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep contribute to overnight episodic memory processes but their roles differ. Episodic memory may have evolved from memory for spatial navigation in animals and humans. Equally, mnemonic navigation in world and mental space may rely ...

journal_title：Neurobiology of learning and memory

authors： Llewellyn S,Hobson JA

更新日期：2015-07-01 00:00:00

abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...

journal_title：Neurobiology of learning and memory

authors： Turner LF,Liu Z,Bures J

更新日期：1997-07-01 00:00:00

abstract：:It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...

journal_title：Neurobiology of learning and memory

authors： Roesler R

更新日期：2017-07-01 00:00:00

abstract：:Glucocorticoid receptor activation within the basolateral amygdala (BLA) during fear conditioning may mediate enhancement in rats chronically exposed to stress levels of corticosterone. Male Sprague-Dawley rats received corticosterone (400 microg/ml) in their drinking water (days 1-21), a manipulation that was previou...

journal_title：Neurobiology of learning and memory

authors： Conrad CD,MacMillan DD 2nd,Tsekhanov S,Wright RL,Baran SE,Fuchs RA

更新日期：2004-05-01 00:00:00

abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

journal_title：Neurobiology of learning and memory

authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

更新日期：2021-01-19 00:00:00

abstract：:The study of bidirectional conditioning began more than a century ago, yet it has failed to take strong root in psychology and neuroscience. We revisit this topic by exploiting E. A. Asratyan's alternating procedure of stimulus presentation, in which both forward (e.g., A → B) and backward (e.g., B → A) training trial...

journal_title：Neurobiology of learning and memory

authors： Navarro VM,Wasserman EA

更新日期：2020-05-01 00:00:00

abstract：:Complex motor skill learning, but not mere motor activity, leads to an increase in synapse number within the cerebellar cortex. The present experiment used quantitative electron microscopy to determine which synapse types were altered in number. Adult female rats were allocated to either an acrobatic condition (AC), a...

journal_title：Neurobiology of learning and memory

authors： Kleim JA,Swain RA,Armstrong KA,Napper RM,Jones TA,Greenough WT

更新日期：1998-05-01 00:00:00

abstract：:The dynamics of learning in the Active Avoidance test was analyzed at the trials level as well as at the level of daily sessions, each comprising numerous trials. The two scales (large scale for the sessions and small scale for the trials) were demonstrated to be mutually independent. The intermediate derived scales (...

journal_title：Neurobiology of learning and memory

authors： Giuliani A,Mancini AM,Ghirardi O,Ramacci MT,Voronina T,Sirabella P,Colosimo A

更新日期：1996-01-01 00:00:00

abstract：:Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female r...

journal_title：Neurobiology of learning and memory

authors： Fenton GE,Halliday DM,Mason R,Bredy TW,Stevenson CW

更新日期：2016-11-01 00:00:00

abstract：:Chronic stress leads to a dysregulated inhibitory tone that could impact hippocampal-dependent spatial learning and memory. The present study examined whether spatial memory deficits resulting from chronic stress could be overcome by antagonizing the GABAA receptor, a prominent inhibitory receptor of GABA in the hippo...

journal_title：Neurobiology of learning and memory

authors： Nishimura KJ,Ortiz JB,Conrad CD

更新日期：2017-11-01 00:00:00

abstract：:The hippocampus is heavily involved in the learning and memory processes necessary to successfully encode environmental stimuli and representations over time. Impairment of hippocampal function is associated with numerous neuropsychiatric diseases and can lead to detriments in the quality of life. In order to take ful...

journal_title：Neurobiology of learning and memory

authors： Josey M,Brigman JL

更新日期：2015-11-01 00:00:00

abstract：:Fetal alcohol exposure in human and rodents produces a number of cognitive deficits including impairments in learning and memory. Recent evidence in our laboratory has shown that fetal alcohol-exposed (FAE) rats respond differently to systemic administration of cholinergic drugs when tested for vigilance and locomotor...

journal_title：Neurobiology of learning and memory

authors： Nagahara AH,Handa RJ

更新日期：1999-11-01 00:00:00

abstract：:Pre-verbal infants and non-human animals associate small numbers with the left space and large numbers with the right space. Birds and primates, trained to identify a given position in a sagittal series of identical positions, whenever required to respond on a left/right oriented series, referred the given position st...

journal_title：Neurobiology of learning and memory

authors： Rugani R,Vallortigara G,Regolin L

更新日期：2016-09-01 00:00:00

abstract：:Alzheimer's disease (AD), a neurodegenerative disorder exhibiting progressive loss of memory and cognitive functions, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and β-amyloid (Aβ) peptide. Drug delivery to the brain still remains highly challenging for the treatment of AD....

journal_title：Neurobiology of learning and memory

authors： Hoppe JB,Coradini K,Frozza RL,Oliveira CM,Meneghetti AB,Bernardi A,Pires ES,Beck RC,Salbego CG

更新日期：2013-11-01 00:00:00

abstract：:Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...

journal_title：Neurobiology of learning and memory

authors： Epstein HT,Child FM,Kuzirian AM,Alkon DL

更新日期：2003-03-01 00:00:00

abstract：:Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pai...

journal_title：Neurobiology of learning and memory

authors： Gould TJ,Higgins JS

更新日期：2003-09-01 00:00:00

abstract：:Traditional learning theory has developed models that can accurately predict and describe the course of learned behavior. These "psychological process" models rely on hypothetical constructs that are usually thought to be not directly measurable or manipulable. Recently, and mostly in parallel, the neural mechanisms u...

journal_title：Neurobiology of learning and memory

authors： Fanselow MS,Zelikowsky M,Perusini J,Barrera VR,Hersman S

更新日期：2014-02-01 00:00:00

abstract：:The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...

journal_title：Neurobiology of learning and memory

authors： Oboh AM,Paredes RG,Baum MJ

更新日期：1995-01-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

journal_title：Neurobiology of learning and memory

authors： Quartermain D,Garcia deSoria V

更新日期：2001-07-01 00:00:00

abstract：:Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the ...

journal_title：Neurobiology of learning and memory

authors： Torregrossa MM,Corlett PR,Taylor JR

更新日期：2011-11-01 00:00:00

abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...

journal_title：Neurobiology of learning and memory

authors： Chatburn A,Lushington K,Kohler MJ

更新日期：2021-01-15 00:00:00