abstract：:Human genetic studies established MET gene as a risk factor for autism spectrum disorders. We have previously shown that signaling mediated by MET receptor tyrosine kinase, expressed in early postnatal developing forebrain circuits, controls glutamatergic neuron morphological development, synapse maturation, and corti...

journal_title：Neurobiology of learning and memory

authors： Xia B,Wei J,Ma X,Nehme A,Liong K,Cui Y,Chen C,Gallitano A,Ferguson D,Qiu S

更新日期：2021-01-29 00:00:00

abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

journal_title：Neurobiology of learning and memory

authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

更新日期：2021-01-19 00:00:00

abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...

journal_title：Neurobiology of learning and memory

authors： Chatburn A,Lushington K,Kohler MJ

更新日期：2021-01-15 00:00:00

abstract：:Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...

journal_title：Neurobiology of learning and memory

authors： Houlton J,Barwick D,Clarkson AN

更新日期：2021-01-01 00:00:00

abstract：:The selective norepinephrine (NE) α2A-adrenoceptor (α2A-AR) agonist, guanfacine (Intuniv™), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story. Guanfacine is also widely used off-label in additional mental disorders that involve impa...

journal_title：Neurobiology of learning and memory

authors： Arnsten AFT

更新日期：2020-12-01 00:00:00

abstract：:Spatial orientation is a cognitive ability that is indispensable for survival. Several visual distal cues present in the context can be integrated, establishing a cognitive map. Although there is cumulative evidence about the neural substrate involved in spatial memory acquisition, the brain networks mediating the pro...

journal_title：Neurobiology of learning and memory

authors： Zorzo C,Arias JL,Méndez M

更新日期：2020-11-01 00:00:00

abstract：:Research has shown that a single presentation of the conditioned stimulus prior to extinction training can diminish conditioned responses. However, replication has proven difficult and appears to be limited by boundary conditions. Here we tested the boundary condition of memory strength by comparing the effect of rein...

journal_title：Neurobiology of learning and memory

authors： Kitamura H,Johnston P,Johnson L,Strodl E

更新日期：2020-10-01 00:00:00

abstract：:Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear conditioning, particularly in the expression of fear to poor predictors ...

journal_title：Neurobiology of learning and memory

authors： Ressler RL,Goode TD,Evemy C,Maren S

更新日期：2020-10-01 00:00:00

abstract：:Physical exercise can improve cognitive functions and promote learning and memory, especially when performed in close temporal proximity to the encoding of information. This benefit may occur due to circulating stress hormones released in response to acute exercise. When administered after encoding, acute stress typic...

journal_title：Neurobiology of learning and memory

authors： Jentsch VL,Wolf OT

更新日期：2020-09-01 00:00:00

abstract：:Aging is associated with cognitive decline, specifically in episodic memory. However, there are large individual differences in the extent of this decline and previous research suggests that these are associated with differences in executive functioning (EF). These EF differences, and associated differences in the enc...

journal_title：Neurobiology of learning and memory

authors： Fu L,Maes JHR,Kessels RPC,Huijbers W

更新日期：2020-09-01 00:00:00

abstract：:Intellectual disability is a common feature in genetic disorders with enhanced RAS-ERK1/2 signaling, including neurofibromatosis type 1 (NF1) and Noonan syndrome (NS). Additional training trials and additional spacing between trials, respectively, restores memory deficits in animal models of NF1 and NS. However, the r...

journal_title：Neurobiology of learning and memory

authors： Cattaneo V,San Martin A,Lew SE,Gelb BD,Pagani MR

更新日期：2020-07-01 00:00:00

abstract：:The study of bidirectional conditioning began more than a century ago, yet it has failed to take strong root in psychology and neuroscience. We revisit this topic by exploiting E. A. Asratyan's alternating procedure of stimulus presentation, in which both forward (e.g., A → B) and backward (e.g., B → A) training trial...

journal_title：Neurobiology of learning and memory

authors： Navarro VM,Wasserman EA

更新日期：2020-05-01 00:00:00

abstract：:Differences in cytoarchitectural organization and connectivity distinguishes granular (or area 29, A29) and dysgranular (or area 30, A30) subdivisions of the retrosplenial cortex (RSC). Although increasing evidence supports the participation of RSC in contextual fear learning and memory, the contribution of each RSC s...

journal_title：Neurobiology of learning and memory

authors： Sigwald EL,de Olmos S,Lorenzo A

更新日期：2020-05-01 00:00:00

abstract：:Previous studies showed that healthy young adults who spontaneously use caudate nucleus-dependent strategies on a virtual navigation task, have significantly lower basal levels of cortisol compared with adults who use hippocampus-dependent spatial navigation strategies. In the current paper, we assessed the relation b...

journal_title：Neurobiology of learning and memory

authors： Blanchette CA,Kurdi V,Fouquet C,Schachar R,Boivin M,Hastings P,Robaey P,West GL,Bohbot VD

更新日期：2020-03-01 00:00:00

abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...

journal_title：Neurobiology of learning and memory

authors： Rohan JG,Miklasevich MK,McInturf SM,Bechmann NA,Moore RJ,Hatcher-Solis C,Jankord R

更新日期：2020-01-01 00:00:00

abstract：:It is widely accepted that unitization can promote familiarity-based associative recognition, but the role of unitization in recognition of individual component elements which originate from compound words remains unclear. The goals of this study were to elaborate on how unitization affects item recognition and furthe...

journal_title：Neurobiology of learning and memory

authors： Liu Z,Wu J,Wang Y,Guo C

更新日期：2020-01-01 00:00:00

abstract：:The beneficial effects of caloric restriction (CR) on health and life expectancy are well documented, although its ability to slow down age-dependent cognitive decline and the underlying biochemical changes remains unclear. Therefore, the aim of this study was to investigate the effects of CR on spatial memory in aged...

journal_title：Neurobiology of learning and memory

authors： Rojic-Becker D,Portero-Tresserra M,Martí-Nicolovius M,Vale-Martínez A,Guillazo-Blanch G

更新日期：2019-12-01 00:00:00

abstract：:Female reproductive experience has been shown to alter the hormonal, neurobiological and behavioural features of fear extinction, which is the laboratory basis of exposure therapy. This raises uncertainties as to whether pharmacological agents that enhance fear extinction in reproductively inexperienced females are eq...

journal_title：Neurobiology of learning and memory

authors： Tang S,Graham BM

更新日期：2019-12-01 00:00:00

abstract：:The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become "destabilized". This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memories. One component of this process involves the rapid internalization of...

journal_title：Neurobiology of learning and memory

authors： Ferrara NC,Trask S,Pullins SE,Helmstetter FJ

更新日期：2019-12-01 00:00:00

abstract：:MsrB1 belongs to the methionine sulfoxide reductase family, it is also known as selenoprotein R for the sake of possessing a selenocysteine residue. It has been reported that MsrB1 could interact with actin, TRPM6, clusterin, and amyloid-beta in vitro. Thus, we presumed that MsrB1 may play an important role in central...

journal_title：Neurobiology of learning and memory

authors： Shi T,Yang Y,Zhang Z,Zhang L,Song J,Ping Y,Du X,Song G,Liu Q,Li N

更新日期：2019-12-01 00:00:00

abstract：:Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mu...

journal_title：Neurobiology of learning and memory

authors： Kerner-Rossi M,Gulinello M,Walkley S,Dobrenis K

更新日期：2019-11-01 00:00:00

abstract：:Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2-8 months) and middle-aged (12-18 months) male Wistar RccHan rats, to test for early age-related impairment in working memory. Novel object recognition (NOR) was included as a comparison task, to provide a positive control in the event th...

journal_title：Neurobiology of learning and memory

authors： Marshall HJ,Pezze MA,Fone KCF,Cassaday HJ

更新日期：2019-10-01 00:00:00

abstract：:The current review provides a historical perspective on the evolution of hypothesized mechanisms for senescent neurophysiology, focused on the CA1 region of the hippocampus, and the relationship of senescent neurophysiology to impaired hippocampal-dependent memory. Senescent neurophysiology involves processes linked t...

journal_title：Neurobiology of learning and memory

authors： Foster TC

更新日期：2019-10-01 00:00:00

abstract：:In spite of evidence about negative effects of Nandrolone Decanoate (ND) on cognitive and memory performance, the underlying mechanisms are complex and have remained unclear. This research examines the role of Calcineurin in synaptic plasticity and memory storage impairment in ND administrated adolescent male rats. Fo...

journal_title：Neurobiology of learning and memory

authors： Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2019-09-01 00:00:00

abstract：:Memory is related to the function of N-methyl-D-aspartate (NMDA) receptors. Depending on the dose, NMDA receptor antagonists (such as memantine or MK-801) can impair memory and/or cognitive as well as procedural functions, while they also can prevent the long-term toxic effects of over-excitation of these receptors in...

journal_title：Neurobiology of learning and memory

authors： Wesierska M,Svoboda J,Stuchlik A

更新日期：2019-07-01 00:00:00

abstract：:Sign-tracking behavior, in which animals interact with a cue that predicts reward, provides an example of how incentive salience can be attributed to cues and elicit motivation. The nucleus accumbens (NAc) and ventral pallidum (VP) are two regions involved in cue-driven motivation. The VP, and NAc subregions including...

journal_title：Neurobiology of learning and memory

authors： Smedley EB,DiLeo A,Smith KS

更新日期：2019-07-01 00:00:00

abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

journal_title：Neurobiology of learning and memory

authors： Collins BE,Sweatt JD,Greer CB

更新日期：2019-05-01 00:00:00

abstract：:Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of re...

journal_title：Neurobiology of learning and memory

authors： Skelin I,Kilianski S,McNaughton BL

更新日期：2019-04-01 00:00:00

abstract：:Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its con...

journal_title：Neurobiology of learning and memory

authors： Oyanedel CN,Sawangjit A,Born J,Inostroza M

更新日期：2019-04-01 00:00:00

abstract：:The hippocampus is important for memory and learning, being a brain site where initial memories are formed and where sharp wave - ripples (SWR) are found, which are responsible for mapping recent memories to long-term storage during sleep-related memory replay. While this conceptual schema is well established, specifi...

journal_title：Neurobiology of learning and memory

authors： Malerba P,Bazhenov M

更新日期：2019-04-01 00:00:00

abstract：:Memories for daily events require that individuals integrate initial fragile traces of events over time. Recent evidence suggests that reward anticipation enhances memory performance and amplifies frontal theta activity for remembered items vs. forgotten items. However, little is known about how incidental rewards aft...

journal_title：Neurobiology of learning and memory

authors： Pu M,Yu R

更新日期：2019-02-01 00:00:00

abstract：:Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how...

journal_title：Neurobiology of learning and memory

authors： Blaes SL,Orsini CA,Holik HM,Stubbs TD,Ferguson SN,Heshmati SC,Bruner MM,Wall SC,Febo M,Bruijnzeel AW,Bizon JL,Setlow B

更新日期：2019-01-01 00:00:00

abstract：:ADHD and its subclinical symptoms have been associated with both disturbed sleep and weakened overnight memory consolidation. As sleep spindle activity during NREM sleep plays a key role in both sleep maintenance and memory consolidation, we examined the association between subclinical ADHD symptoms and sleep spindle ...

journal_title：Neurobiology of learning and memory

authors： Merikanto I,Kuula L,Makkonen T,Halonen R,Lahti J,Heinonen K,Räikkönen K,Pesonen AK

更新日期：2019-01-01 00:00:00

abstract：:Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia i...

journal_title：Neurobiology of learning and memory

authors： Grau-Perales AB,Levy ERJ,Fenton AA,Gallo M

更新日期：2019-01-01 00:00:00

abstract：:Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g., visuospatial interference tasks, like Tetris) have been shown to be effective at disrupting reactivated memory. In the present study, participants created a memory ...

journal_title：Neurobiology of learning and memory

authors： Gotthard GH,Gura H

更新日期：2018-12-01 00:00:00

abstract：:Individual differences in regulation of fear and extinction memory play significant roles in the aetiology development of post-traumatic stress disorder (PTSD). Previous animal based studies showed that the activity of β-adrenergic receptors (β-ARs) are involved in memory modulation. However in humans it is not clear ...

journal_title：Neurobiology of learning and memory

authors： Shi L,Chen SJ,Deng JH,Que JY,Lin X,Sun Y,Bao YP,Shi J,Lu L

更新日期：2018-12-01 00:00:00

abstract：:Most long-term memories are forgotten, becoming progressively less likely to be recalled. Still, some memory fragments may persist, as savings memory (easier relearning) can be detected long after recall has become impossible. What happens to a memory trace during forgetting that makes it inaccessible for recall and y...

journal_title：Neurobiology of learning and memory

authors： Patel U,Perez L,Farrell S,Steck D,Jacob A,Rosiles T,Krause E,Nguyen M,Calin-Jageman RJ,Calin-Jageman IE

更新日期：2018-11-01 00:00:00

abstract：:Animals tend to repeat actions that are associated with reward delivery, whereas they tend to shift responses to alternate choices following reward omission. These so-called win-stay and lose-shift responses are employed by a wide range of animals in a variety of decision-making scenarios, and depend on dissociated re...

journal_title：Neurobiology of learning and memory

authors： Thapa R,Gruber AJ

更新日期：2018-11-01 00:00:00

abstract：:Viral infection during early stage of life influences brain development and results in several neurodevelopmental disorders such as schizophrenia, autism and behavioral abnormalities. However, the mechanism through which infection causes long-term behavioral defects is not well known. To elucidate this, we have used s...

journal_title：Neurobiology of learning and memory

authors： Baghel MS,Singh B,Dhuriya YK,Shukla RK,Patro N,Khanna VK,Patro IK,Thakur MK

更新日期：2018-11-01 00:00:00

abstract：:Post-training sleep benefits both declarative and procedural memory consolidation. However, recent research suggests that eyes-closed waking rest may provide a similar benefit. Brokaw et al. (2016), for example, recently demonstrated that verbal declarative memory improved more following a 15 min period of waking rest...

journal_title：Neurobiology of learning and memory

authors： Humiston GB,Wamsley EJ

更新日期：2018-11-01 00:00:00