Fetal alcohol-exposed rats exhibit differential response to cholinergic drugs on a delay-dependent memory task.

abstract：:Although septal infusions of glucose typically have positive effects on memory, we have shown repeatedly that this treatment exacerbates memory deficits produced by co-infusions of gamma-aminobutyric acid (GABA) receptor agonists. The present experiments tested whether this negative interaction between glucose and GAB...

journal_title：Neurobiology of learning and memory

authors： Krebs-Kraft DL,Parent MB

更新日期：2008-02-01 00:00:00

abstract：:Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear conditioning, particularly in the expression of fear to poor predictors ...

journal_title：Neurobiology of learning and memory

authors： Ressler RL,Goode TD,Evemy C,Maren S

更新日期：2020-10-01 00:00:00

abstract：:Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippoca...

journal_title：Neurobiology of learning and memory

authors： Hales JB,Ocampo AC,Broadbent NJ,Clark RE

更新日期：2016-12-01 00:00:00

abstract：:The selective norepinephrine (NE) α2A-adrenoceptor (α2A-AR) agonist, guanfacine (Intuniv™), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story. Guanfacine is also widely used off-label in additional mental disorders that involve impa...

journal_title：Neurobiology of learning and memory

authors： Arnsten AFT

更新日期：2020-12-01 00:00:00

abstract：:Sign-tracking behavior, in which animals interact with a cue that predicts reward, provides an example of how incentive salience can be attributed to cues and elicit motivation. The nucleus accumbens (NAc) and ventral pallidum (VP) are two regions involved in cue-driven motivation. The VP, and NAc subregions including...

journal_title：Neurobiology of learning and memory

authors： Smedley EB,DiLeo A,Smith KS

更新日期：2019-07-01 00:00:00

abstract：:Recent data have demonstrated a biochemical sequence of events in the rat hippocampus that is necessary for memory formation of inhibitory avoidance behavior. The sequence initially involves the activation of three different types of glutamate receptors followed by changes in second messengers and biochemical cascades...

journal_title：Neurobiology of learning and memory

authors： Izquierdo I,Medina JH

更新日期：1997-11-01 00:00:00

abstract：:Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the ...

journal_title：Neurobiology of learning and memory

authors： Torregrossa MM,Corlett PR,Taylor JR

更新日期：2011-11-01 00:00:00

abstract：:Sleep facilitates declarative memory processing. However, we know little about whether sleep plays a role in the processing of a fundamental feature of declarative memory, relational memory - the flexible representation of items not directly learned prior to sleep. Thirty-one healthy participants first learned at 12 p...

journal_title：Neurobiology of learning and memory

authors： Lau H,Tucker MA,Fishbein W

更新日期：2010-05-01 00:00:00

abstract：:Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how...

journal_title：Neurobiology of learning and memory

authors： Blaes SL,Orsini CA,Holik HM,Stubbs TD,Ferguson SN,Heshmati SC,Bruner MM,Wall SC,Febo M,Bruijnzeel AW,Bizon JL,Setlow B

更新日期：2019-01-01 00:00:00

abstract：:Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. ...

journal_title：Neurobiology of learning and memory

authors： von Leden RE,Curley LC,Greenberg GD,Hunsaker MR,Willemsen R,Berman RF

更新日期：2014-03-01 00:00:00

abstract：:Most models of human and animal learning assume that learning is proportional to the discrepancy between a delivered outcome and the outcome predicted by all cues present during that trial (i.e., total error across a stimulus compound). This total error reduction (TER) view has been implemented in connectionist and ar...

journal_title：Neurobiology of learning and memory

authors： Witnauer JE,Urcelay GP,Miller RR

更新日期：2014-02-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

journal_title：Neurobiology of learning and memory

authors： Stilling RM,Fischer A

更新日期：2011-07-01 00:00:00

abstract：:Addiction is increasingly discussed asa disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions t...

journal_title：Neurobiology of learning and memory

authors： Ehlers MR,Todd RM

更新日期：2017-11-01 00:00:00

abstract：:Memory is related to the function of N-methyl-D-aspartate (NMDA) receptors. Depending on the dose, NMDA receptor antagonists (such as memantine or MK-801) can impair memory and/or cognitive as well as procedural functions, while they also can prevent the long-term toxic effects of over-excitation of these receptors in...

journal_title：Neurobiology of learning and memory

authors： Wesierska M,Svoboda J,Stuchlik A

更新日期：2019-07-01 00:00:00

abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

journal_title：Neurobiology of learning and memory

authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

更新日期：2021-01-19 00:00:00

abstract：:The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...

journal_title：Neurobiology of learning and memory

authors： Oboh AM,Paredes RG,Baum MJ

更新日期：1995-01-01 00:00:00

abstract：:It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the fo...

journal_title：Neurobiology of learning and memory

authors： Havekes R,Nijholt IM,Visser AK,Eisel UL,Van der Zee EA

更新日期：2008-05-01 00:00:00

abstract：:Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female r...

journal_title：Neurobiology of learning and memory

authors： Fenton GE,Halliday DM,Mason R,Bredy TW,Stevenson CW

更新日期：2016-11-01 00:00:00

abstract：:Human genetic studies established MET gene as a risk factor for autism spectrum disorders. We have previously shown that signaling mediated by MET receptor tyrosine kinase, expressed in early postnatal developing forebrain circuits, controls glutamatergic neuron morphological development, synapse maturation, and corti...

journal_title：Neurobiology of learning and memory

authors： Xia B,Wei J,Ma X,Nehme A,Liong K,Cui Y,Chen C,Gallitano A,Ferguson D,Qiu S

更新日期：2021-01-29 00:00:00

abstract：:The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of whether intranasally applied pregnenolone (IN-PREG) also has promnestic properties in the rat. We examined the effects of IN-PREG at doses of 0.187 and 0.373mg/kg on memo...

journal_title：Neurobiology of learning and memory

authors： Abdel-Hafiz L,Chao OY,Huston JP,Nikolaus S,Spieler RE,de Souza Silva MA,Mattern C

更新日期：2016-09-01 00:00:00

abstract：:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after traini...

journal_title：Neurobiology of learning and memory

authors： Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CA

更新日期：2002-09-01 00:00:00

abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

journal_title：Neurobiology of learning and memory

authors： Collins BE,Sweatt JD,Greer CB

更新日期：2019-05-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are critically involved in various learning mechanisms including modulation of fear memory, brain development and brain disorders. While NMDARs mediate opposite effects on medial prefrontal cortex (mPFC) interneurons and excitatory neurons, NMDAR antagonists trigger profound cor...

journal_title：Neurobiology of learning and memory

authors： Vieira PA,Corches A,Lovelace JW,Westbrook KB,Mendoza M,Korzus E

更新日期：2015-03-01 00:00:00

abstract：:Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form of discrepancies between actual and expected reward outcomes. Additionally, in learn...

journal_title：Neurobiology of learning and memory

authors： Hart AS,Clark JJ,Phillips PEM

更新日期：2015-01-01 00:00:00

abstract：:The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine ar...

journal_title：Neurobiology of learning and memory

authors： Soares JC,Fornari RV,Oliveira MG

更新日期：2006-09-01 00:00:00

abstract：:Anxiety disorders and obesity are both common in youth and young adults. Despite increasing evidence that over-consumption of palatable high-fat/high-sugar "junk" foods leads to adverse neurocognitive outcomes, little is known about the effects of palatable diets on emotional memories and fear regulation. In the prese...

journal_title：Neurobiology of learning and memory

authors： Baker KD,Reichelt AC

更新日期：2016-12-01 00:00:00

abstract：:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippo...

journal_title：Neurobiology of learning and memory

authors： Krawczyk MC,Navarro N,Blake MG,Romano A,Feld M,Boccia MM

更新日期：2016-09-01 00:00:00

abstract：:Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of re...

journal_title：Neurobiology of learning and memory

authors： Skelin I,Kilianski S,McNaughton BL

更新日期：2019-04-01 00:00:00

abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

journal_title：Neurobiology of learning and memory

authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

更新日期：2018-11-01 00:00:00