Conditional knockout of MET receptor tyrosine kinase in cortical excitatory neurons leads to enhanced learning and memory in young adult mice but early cognitive decline in older adult mice.

abstract：:Previous studies showed that healthy young adults who spontaneously use caudate nucleus-dependent strategies on a virtual navigation task, have significantly lower basal levels of cortisol compared with adults who use hippocampus-dependent spatial navigation strategies. In the current paper, we assessed the relation b...

journal_title：Neurobiology of learning and memory

authors： Blanchette CA,Kurdi V,Fouquet C,Schachar R,Boivin M,Hastings P,Robaey P,West GL,Bohbot VD

更新日期：2020-03-01 00:00:00

abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...

journal_title：Neurobiology of learning and memory

authors： Shors TJ

更新日期：2006-03-01 00:00:00

abstract：:Reinforcement learning enables organisms to adjust their behavior in order to maximize rewards. Electrophysiological recordings of dopaminergic midbrain neurons have shown that they code the difference between actual and predicted rewards, i.e., the reward prediction error, in many species. This error signal is convey...

journal_title：Neurobiology of learning and memory

authors： Daniel R,Pollmann S

更新日期：2014-10-01 00:00:00

abstract：:It has been known for a long time that cholinergic basal forebrain neurons which project to the cerebral cortex play a role in learning and memory. Behavioral studies following lesions, for example, repeatedly have suggested multiple learning-related roles for these neurons. Apart from behavioral studies, cholinergic ...

journal_title：Neurobiology of learning and memory

authors： Woolf NJ

更新日期：1996-11-01 00:00:00

abstract：:The shell division of the nucleus accumbens receives noradrenergic input from neurons in the nucleus of the solitary tract (NTS) that transmit information regarding fluctuations in peripheral hormonal and autonomic activity. Accumbens shell neurons also receive converging inputs from limbic areas such as the hippocamp...

journal_title：Neurobiology of learning and memory

authors： Kerfoot EC,Chattillion EA,Williams CL

更新日期：2008-01-01 00:00:00

abstract：:Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...

journal_title：Neurobiology of learning and memory

authors： Epstein HT,Child FM,Kuzirian AM,Alkon DL

更新日期：2003-03-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...

journal_title：Neurobiology of learning and memory

authors： Alvarenga TA,Patti CL,Andersen ML,Silva RH,Calzavara MB,Lopez GB,Frussa-Filho R,Tufik S

更新日期：2008-11-01 00:00:00

abstract：:Differences in cytoarchitectural organization and connectivity distinguishes granular (or area 29, A29) and dysgranular (or area 30, A30) subdivisions of the retrosplenial cortex (RSC). Although increasing evidence supports the participation of RSC in contextual fear learning and memory, the contribution of each RSC s...

journal_title：Neurobiology of learning and memory

authors： Sigwald EL,de Olmos S,Lorenzo A

更新日期：2020-05-01 00:00:00

abstract：:Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...

journal_title：Neurobiology of learning and memory

authors： Buttigieg A,Flores O,Hernández A,Sáez-Briones P,Burgos H,Morgan C

更新日期：2014-01-01 00:00:00

abstract：:The healthy aging process affects the ability to learn and remember new facts and tasks. Prior work has shown that motor learning can be adversely affected by non-motor deficits, such as time. Here we investigated how age, and a dual task influence the learning and forgetting of a new walking pattern. We studied healt...

journal_title：Neurobiology of learning and memory

authors： Malone LA,Bastian AJ

更新日期：2016-02-01 00:00:00

abstract：:In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague-Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age...

journal_title：Neurobiology of learning and memory

authors： Hunt PS,Barnet RC,Shea ME,Baker EM

更新日期：2006-11-01 00:00:00

abstract：:Learning is ubiquitous in the animal kingdom but has been studied extensively in only a handful of species. Moreover, learning studied under laboratory conditions is typically unrelated to the animal's natural environment or life history. Here, we designed a task relevant to the natural behavior of male African cichli...

journal_title：Neurobiology of learning and memory

authors： Wood LS,Desjardins JK,Fernald RD

更新日期：2011-03-01 00:00:00

abstract：:This article argues both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep contribute to overnight episodic memory processes but their roles differ. Episodic memory may have evolved from memory for spatial navigation in animals and humans. Equally, mnemonic navigation in world and mental space may rely ...

journal_title：Neurobiology of learning and memory

authors： Llewellyn S,Hobson JA

更新日期：2015-07-01 00:00:00

abstract：:The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...

journal_title：Neurobiology of learning and memory

authors： Oboh AM,Paredes RG,Baum MJ

更新日期：1995-01-01 00:00:00

abstract：:Every learning event is embedded in a context, but not always does the context become an integral part of the memory; however, for extinction learning it usually does, resulting in context-specific conditioned responding. The neuronal mechanisms underlying contextual control have been mainly investigated for Pavlovian...

journal_title：Neurobiology of learning and memory

authors： Starosta S,Bartetzko I,Stüttgen MC,Güntürkün O

更新日期：2017-10-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form of discrepancies between actual and expected reward outcomes. Additionally, in learn...

journal_title：Neurobiology of learning and memory

authors： Hart AS,Clark JJ,Phillips PEM

更新日期：2015-01-01 00:00:00

abstract：:In the marine snail Hermissenda, associative learning can be accomplished by paired presentations of light and vestibular stimulation. It is generally assumed that associative learning depends upon the intensity or salience of the conditioned or unconditioned stimulus (CS and US, respectively). Accordingly, during Her...

journal_title：Neurobiology of learning and memory

authors： Tomsic D,Alkon DL

更新日期：2000-07-01 00:00:00

abstract：:The prefrontal cortex is known to be involved in the acquisition of trace conditioning, a higher-cognitive form of Pavlovian conditioning in which a conditioned stimulus and an unconditioned stimulus are separated by a time gap. We have recently reported that medial prefrontal (mPFC) extracellular-signal regulated kin...

journal_title：Neurobiology of learning and memory

authors： Runyan JD,Dash PK

更新日期：2004-09-01 00:00:00

abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...

journal_title：Neurobiology of learning and memory

authors： Beggiato S,Borelli AC,Tomasini MC,Morgano L,Antonelli T,Tanganelli S,Cuomo V,Ferraro L

更新日期：2017-03-01 00:00:00

abstract：:An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose pok...

journal_title：Neurobiology of learning and memory

authors： Larson J,Kim D,Patel RC,Floreani C

更新日期：2008-07-01 00:00:00

abstract：:Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/micro...

journal_title：Neurobiology of learning and memory

authors： Edeline JM,Hars B,Hennevin E,Cotillon N

更新日期：2002-07-01 00:00:00

abstract：:We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on h...

journal_title：Neurobiology of learning and memory

authors： Van der Jeugd A,Ahmed T,Burnouf S,Belarbi K,Hamdame M,Grosjean ME,Humez S,Balschun D,Blum D,Buée L,D'Hooge R

更新日期：2011-03-01 00:00:00

abstract：:The purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, Extracellular signal-Regulated Kinase (ERK) and Mammalian Target of Rapamycin (mTOR) pathways in the development of short and long term memories during the acquisition and recall of the step-down inhibitory ...

journal_title：Neurobiology of learning and memory

authors： Giovannini MG,Lana D,Pepeu G

更新日期：2015-03-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...

journal_title：Neurobiology of learning and memory

authors： Tai CT,Cassaday HJ,Feldon J,Rawlins JN

更新日期：1995-07-01 00:00:00

abstract：:Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia i...

journal_title：Neurobiology of learning and memory

authors： Grau-Perales AB,Levy ERJ,Fenton AA,Gallo M

更新日期：2019-01-01 00:00:00

abstract：:Androgens can have performance-enhancing effects in some cognitive tasks, but the mechanism of these effects has not been established. Experiments examined whether androgens' actions to bind to intracellular androgen receptors (ARs) in the hippocampus are necessary to enhance cognitive performance in the inhibitory av...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-02-01 00:00:00

abstract：:Inappropriate defense-alerting reaction to fear is a common feature of neuropsychiatric diseases. Therefore, impairments in brain circuits, as well as in molecular pathways underlying the neurovegetative adjustments to fear may play an essential role on developing neuropsychiatric disorders. Here we tested the hypothe...

journal_title：Neurobiology of learning and memory

authors： Lazaroni TL,Bastos CP,Moraes MF,Santos RS,Pereira GS

更新日期：2016-01-01 00:00:00

abstract：:Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the ...

journal_title：Neurobiology of learning and memory

authors： Torregrossa MM,Corlett PR,Taylor JR

更新日期：2011-11-01 00:00:00