当前位置： SCI文献检索 > NEUROBIOLOGY OF LEARNING AND MEMORY期刊下所有文献 > Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats.

Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats.

Abstract：

:Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesions in the shell region of the nucleus accumbens. Latent inhibition was attenuated by this lesion. In order to determine the contribution made by damage to fibers en passage associated with electrolytic lesions, Experiment 2 assessed the effects of NMDA-induced lesions in the shell of the nucleus accumbens in the same task. Latent inhibition was again significantly attenuated. These findings support the proposition that an intact nucleus accumbens is necessary for the normal development of latent inhibition.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Tai CT,Cassaday HJ,Feldon J,Rawlins JN

doi

10.1006/nlme.1995.1042

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

36-48

issue

1

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(85)71042-8

journal_volume

64

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF LEARNING AND MEMORY文献大全
  • Intra-medial prefrontal administration of SCH-23390 attenuates ERK phosphorylation and long-term memory for trace fear conditioning in rats.

    abstract：:The prefrontal cortex is known to be involved in the acquisition of trace conditioning, a higher-cognitive form of Pavlovian conditioning in which a conditioned stimulus and an unconditioned stimulus are separated by a time gap. We have recently reported that medial prefrontal (mPFC) extracellular-signal regulated kin...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2004.04.006

    authors： Runyan JD,Dash PK

    更新日期：2004-09-01 00:00:00

  • The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory.

    abstract：:The purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, Extracellular signal-Regulated Kinase (ERK) and Mammalian Target of Rapamycin (mTOR) pathways in the development of short and long term memories during the acquisition and recall of the step-down inhibitory ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2014.12.014

    authors： Giovannini MG,Lana D,Pepeu G

    更新日期：2015-03-01 00:00:00

  • Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome.

    abstract：:Spatial working memory and the ability of a cholinesterase inhibitor to enhance memory were assessed at 4, 10, and 16 months of ages in control and Ts65Dn mice, a partial trisomy model of Down syndrome, with possibly significant relationships to Alzheimer's disease as well. In addition, ACh release during memory testi...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.05.007

    authors： Chang Q,Gold PE

    更新日期：2008-02-01 00:00:00

  • Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation.

    abstract：:MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.02.010

    authors： Gulmez Karaca K,Brito DVC,Zeuch B,Oliveira AMM

    更新日期：2018-03-01 00:00:00

  • Effects of oral cortisol treatment in healthy young women on memory retrieval of negative and neutral words.

    abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

    journal_title：Neurobiology of learning and memory

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.nlm.2004.09.001

    authors： Kuhlmann S,Kirschbaum C,Wolf OT

    更新日期：2005-03-01 00:00:00

  • Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout mice.

    abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2009.06.012

    authors： McKinney BC,Sze W,Lee B,Murphy GG

    更新日期：2009-11-01 00:00:00

  • Subordinate male mice show long-lasting differences in spatial learning that persist when housed alone.

    abstract：:In the wild, house mice live in social groups, whereas in the laboratory male mice are often singly housed. Environmental enrichment such as that provided by social housing has been argued to improve the cognitive performance of laboratory animals in experimental tests. The aim of the present study was to test the cos...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2005.08.004

    authors： Fitchett AE,Collins SA,Barnard CJ,Cassaday HJ

    更新日期：2005-11-01 00:00:00

  • Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories.

    abstract：:It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the fo...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.08.003

    authors： Havekes R,Nijholt IM,Visser AK,Eisel UL,Van der Zee EA

    更新日期：2008-05-01 00:00:00

  • Daytime napping: Effects on human direct associative and relational memory.

    abstract：:Sleep facilitates declarative memory processing. However, we know little about whether sleep plays a role in the processing of a fundamental feature of declarative memory, relational memory - the flexible representation of items not directly learned prior to sleep. Thirty-one healthy participants first learned at 12 p...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.nlm.2010.02.003

    authors： Lau H,Tucker MA,Fishbein W

    更新日期：2010-05-01 00:00:00

  • Post-training cocaine administration facilitates habit learning and requires the infralimbic cortex and dorsolateral striatum.

    abstract：:Human drug addiction is a complex disorder, in which exogenous substances are able to recruit and maintain behaviors involved in drug taking. Many drugs that are addictive in humans are able to act on natural brain systems for learning and memory, and while many memory systems may be affected by addictive drugs, work ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.11.007

    authors： Schmitzer-Torbert N,Apostolidis S,Amoa R,O'Rear C,Kaster M,Stowers J,Ritz R

    更新日期：2015-02-01 00:00:00

  • Visuospatial word search task only effective at disrupting declarative memory when prediction error is present during retrieval.

    abstract：:Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g., visuospatial interference tasks, like Tetris) have been shown to be effective at disrupting reactivated memory. In the present study, participants created a memory ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.11.003

    authors： Gotthard GH,Gura H

    更新日期：2018-12-01 00:00:00

  • ADHD symptoms are associated with decreased activity of fast sleep spindles and poorer procedural overnight learning during adolescence.

    abstract：:ADHD and its subclinical symptoms have been associated with both disturbed sleep and weakened overnight memory consolidation. As sleep spindle activity during NREM sleep plays a key role in both sleep maintenance and memory consolidation, we examined the association between subclinical ADHD symptoms and sleep spindle ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.12.004

    authors： Merikanto I,Kuula L,Makkonen T,Halonen R,Lahti J,Heinonen K,Räikkönen K,Pesonen AK

    更新日期：2019-01-01 00:00:00

  • Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway.

    abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2015.11.020

    authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

    更新日期：2016-01-01 00:00:00

  • Transverse patterning reveals a dissociation of simple and configural association learning abilities in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis.

    abstract：:This experiment tests the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is necessary for complex or configural association learning, but not elemental or simple association learning. Male Long-Evans rats with bilateral 192 IgG-saporin lesions of the NBM (n = 12) and sham-operated controls (n = ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2001.4013

    authors： Butt AE,Bowman TD

    更新日期：2002-03-01 00:00:00

  • Differential effects of anterior and posterior insular cortex lesions on the acquisition of conditioned taste aversion and spatial learning.

    abstract：:In this study, we evaluated the effects of NMDA-induced lesions in different sites of the insular cortex of the rat on the acquisition of conditioned taste aversion and spatial learning in the Morris water maze. The lesions were produced by bilateral microinjections of NMDA in the insular cortex at +3.7 mm (Anterior g...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0042

    authors： Nerad L,Ramírez-Amaya V,Ormsby CE,Bermúdez-Rattoni F

    更新日期：1996-07-01 00:00:00

  • Involvement of the sigma receptor in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.

    abstract：:The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lo...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2000.3985

    authors： Freeman FM,Young IG

    更新日期：2001-05-01 00:00:00

  • Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression.

    abstract：:Expression of immediate-early genes, like Egr-1, has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is widely thought to play an important role in long-term memory (LTM) formation. However, little is known about the role of Egr-1 in the maintenance of memory storage. Here...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2012.08.001

    authors： Katche C,Goldin A,Gonzalez C,Bekinschtein P,Medina JH

    更新日期：2012-10-01 00:00:00

  • Nuclear factor kappa B-dependent Zif268 expression in hippocampus is required for recognition memory in mice.

    abstract：:Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-кB), which are present before the neuronal activity induced by training. It was proposed t...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.12.013

    authors： Zalcman G,Federman N,de la Fuente V,Romano A

    更新日期：2015-03-01 00:00:00

  • 5-HT1A receptors modulate the consolidation of learning in normal and cognitively impaired rats.

    abstract：:Attempts were made to further analyze the role of 5-HT1A receptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1A receptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1998.3866

    authors： Meneses A,Hong E

    更新日期：1999-03-01 00:00:00

  • Involvement of the basolateral amygdala in muscarinic cholinergic modulation of extinction memory consolidation.

    abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2008.07.012

    authors： Boccia MM,Blake MG,Baratti CM,McGaugh JL

    更新日期：2009-01-01 00:00:00

  • Lesions of ventrolateral striatum eliminate lose-shift but not win-stay behaviour in rats.

    abstract：:Animals tend to repeat actions that are associated with reward delivery, whereas they tend to shift responses to alternate choices following reward omission. These so-called win-stay and lose-shift responses are employed by a wide range of animals in a variety of decision-making scenarios, and depend on dissociated re...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.08.022

    authors： Thapa R,Gruber AJ

    更新日期：2018-11-01 00:00:00

  • Newly acquired and reactivated contextual fear memories are more intense and prone to generalize after activation of prelimbic cortex NMDA receptors.

    abstract：:Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive a...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.12.002

    authors： Vanvossen AC,Portes MAM,Scoz-Silva R,Reichmann HB,Stern CAJ,Bertoglio LJ

    更新日期：2017-01-01 00:00:00

  • Weak involvement of octopamine in aversive taste learning in a snail.

    abstract：:The pond snail Lymnaea stagnalis is capable of learning taste aversion by pairing presentations of a sucrose solution and an electric shock and consolidating it into long-term memory (LTM), which is referred to as conditioned taste aversion (CTA). We asked here if the neurotransmitter octopamine is involved in CTA. We...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.04.010

    authors： Aonuma H,Kaneda M,Hatakeyama D,Watanabe T,Lukowiak K,Ito E

    更新日期：2017-05-01 00:00:00

  • The critical role of cholinergic basal forebrain neurons in morphological change and memory encoding: a hypothesis.

    abstract：:It has been known for a long time that cholinergic basal forebrain neurons which project to the cerebral cortex play a role in learning and memory. Behavioral studies following lesions, for example, repeatedly have suggested multiple learning-related roles for these neurons. Apart from behavioral studies, cholinergic ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0068

    authors： Woolf NJ

    更新日期：1996-11-01 00:00:00

  • Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation.

    abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.04.009

    authors： Collins BE,Sweatt JD,Greer CB

    更新日期：2019-05-01 00:00:00

  • Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice.

    abstract：:Although environmental enrichment improves spatial memory and alters synaptic plasticity in aged rodents, it is unclear whether all types of enrichment treatments yield similar benefits. The present study examined the effects in aged male mice of three types of enrichment on spatial memory in Morris water maze and rad...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2005.09.003

    authors： Bennett JC,McRae PA,Levy LJ,Frick KM

    更新日期：2006-03-01 00:00:00

  • The influence of sleep on emotional and cognitive processing is primarily trait- (but not state-) dependent.

    abstract：:Human studies of sleep and cognition have established thatdifferent sleep stages contribute to distinct aspects of cognitive and emotional processing. However, since the majority of these findings are based on single-night studies, it is difficult to determine whether such effects arise due to individual, between-subj...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.07.032

    authors： Lerner I,Lupkin SM,Corter JE,Peters SE,Cannella LA,Gluck MA

    更新日期：2016-10-01 00:00:00

  • A therapeutic dose of memantine improves the performance of rats in an active place avoidance task under the continuous dissociation of distal room and proximal arena cues.

    abstract：:Memory is related to the function of N-methyl-D-aspartate (NMDA) receptors. Depending on the dose, NMDA receptor antagonists (such as memantine or MK-801) can impair memory and/or cognitive as well as procedural functions, while they also can prevent the long-term toxic effects of over-excitation of these receptors in...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.03.011

    authors： Wesierska M,Svoboda J,Stuchlik A

    更新日期：2019-07-01 00:00:00

  • The perisylvian language network and language analytical abilities.

    abstract：:Aiming at exploring the brain's structural organisation underlying successful second language learning, we investigate the anatomy of the perisylvian language network in a group of healthy adults, consisting of participants with high and average language analytical abilities. Utilising deterministic tractography, six ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.07.003

    authors： Kepinska O,Lakke EAJF,Dutton EM,Caspers J,Schiller NO

    更新日期：2017-10-01 00:00:00

  • Mechanisms of Context Conditioning in the Developing Rat.

    abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2021.107388

    authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

    更新日期：2021-01-19 00:00:00