Abstract:
:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieval. In this double-blind crossover study, 16 healthy women learned a wordlist containing 15 neutral and 15 negative words. Delayed recall was tested 5h later. Cortisol administered before recall testing significantly reduced retrieval (p<.01). Exploratory follow-up analysis revealed that cortisol significantly impaired retrieval of negative words (p<.01), while having no significant effect on neutral words (p=.47). The current findings could suggest that emotional material is especially sensitive to the memory modulating effects of stress hormones.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Kuhlmann S,Kirschbaum C,Wolf OTdoi
10.1016/j.nlm.2004.09.001keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
158-62issue
2eissn
1074-7427issn
1095-9564pii
S1074-7427(04)00099-1journal_volume
83pub_type
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