Abstract:
:Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the first CS-no US presentation.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Cammarota M,Bevilaqua LR,Rossato JI,Ramirez M,Medina JH,Izquierdo Idoi
10.1016/j.nlm.2005.03.002keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
25-32issue
1eissn
1074-7427issn
1095-9564pii
S1074-7427(05)00020-1journal_volume
84pub_type
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