Relationship between short- and long-term memory and short- and long-term extinction.

Abstract:

:Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the first CS-no US presentation.

journal_name

Neurobiol Learn Mem

authors

Cammarota M,Bevilaqua LR,Rossato JI,Ramirez M,Medina JH,Izquierdo I

doi

10.1016/j.nlm.2005.03.002

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

25-32

issue

1

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(05)00020-1

journal_volume

84

pub_type

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