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Qualitatively different memory states in Lymnaea as shown by differential responses to propranolol.

Abstract：

:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanisms underling memory formation in PTSD are similar to normal memory is not clear. Here, we use Lymnaea to study the effects of combinations of stressors on the quality of the formed memory state. We show reactivation dependent pharmacologic disruption of reconsolidation using propranolol in Lymnaea; specifically, we show that only certain memories created under conditions of a combination of stressors are susceptible to disruption. Our data suggest that phenotypically similar memories may be molecularly diverse, depending on the conditions under which they are formed. Applied to human PTSD, this could account for the mixed results in the literature on disrupting reconsolidation with propranolol.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Hughes E,Shymansky T,Sunada H,Lukowiak K

doi

10.1016/j.nlm.2016.09.013

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

63-73

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(16)30199-X

journal_volume

136

pub_type

杂志文章

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