Abstract：
:Four experiments were conducted to examine social and emotional memory in the R6/2 transgenic mouse model of Huntington's disease. First, R6/2 mice were tested in a social transmission of food preference task where they had to acquire a preference for a flavoured food (acquisition) and subsequently to learn a preference for a different flavour (shifted reinforcement). R6/2 mice performed well in the acquisition trial. However, they were impaired in the shifted reinforcement trial and perseverated on the first preference learned. Second, mice were trained in an inhibitory avoidance paradigm, with either one or two footshocks delivered during the training. WT mice given one footshock showed retention levels lower than those of mice trained with two footshocks. By contrast, there was no difference in retention levels of R6/2 mice given either one or two footshocks. Third, mice were tested in an active avoidance task that paired a mild footshock with a warning light. R6/2 mice had a strong age-dependent deficit in this task. Finally, mice were tested in a conditioned taste aversion task that paired a saccharine solution with a nausea-inducing agent (LiCl). R6/2 mice displayed normal aversion, however this was not extinguished following repeated exposure to saccharine solution alone. Our data show that while R6/2 mice have functional hippocampus-based memory, they have deficits in striatum-based memory skills. Further, social and emotional memories appear to be encoded in a rigid way that is not influenced by subsequent learning or by arousal levels.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Ciamei A,Morton AJdoi
10.1016/j.nlm.2007.10.009subject
Has Abstractpub_date
2008-05-01 00:00:00pages
533-44issue
4eissn
1074-7427issn
1095-9564pii
S1074-7427(07)00173-6journal_volume
89pub_type
杂志文章abstract：:Glucocorticoid receptor activation within the basolateral amygdala (BLA) during fear conditioning may mediate enhancement in rats chronically exposed to stress levels of corticosterone. Male Sprague-Dawley rats received corticosterone (400 microg/ml) in their drinking water (days 1-21), a manipulation that was previou...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2004.01.002
更新日期：2004-05-01 00:00:00
abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.2000.3981
更新日期：2001-07-01 00:00:00
abstract：:Temporal lobe epilepsy patients have demonstrated a relative preservation in the integrity of implicit memory procedures. We examined performance in a verbal implicit and explicit memory task in left anterior temporal lobectomy patients (LATL) and healthy normal controls (NCs) while undergoing fMRI. We hypothesized th...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.08.005
更新日期：2012-10-01 00:00:00
abstract：:Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia i...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.12.009
更新日期：2019-01-01 00:00:00
abstract：:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanis...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.09.013
更新日期：2016-12-01 00:00:00
abstract：:The use of visual habituation in the study of infant cognition and learning is reviewed. This article traces the history of the technique, underlying theory, and procedural variation in its measurement. In addition, we review empirical findings with respect to the cognitive processes that presumably contribute to habi...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2008.06.002
更新日期：2009-09-01 00:00:00
abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.08.004
更新日期：2016-10-01 00:00:00
abstract：:An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose pok...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.01.002
更新日期：2008-07-01 00:00:00
abstract：:Although no single widely accepted animal model of PTSD has been established to date, the single prolonged stress (SPS) animal model has been partially validated as a model for PTSD. SPS rats mimic the pathophysiological abnormalities and behavioral characteristics of PTSD, such as enhanced fear response to the trauma...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2013.02.003
更新日期：2013-05-01 00:00:00
abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.06.012
更新日期：2009-11-01 00:00:00
abstract：:The efficacy of synaptic transmission between two neurons changes as a function of the history of previous activations of the synaptic connection. This history dependence can be characterized by examining the dependence of transmission on the frequency of stimulation. In this framework synaptic plasticity can also be ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1998.3841
更新日期：1998-07-01 00:00:00
abstract：:Female reproductive experience has been shown to alter the hormonal, neurobiological and behavioural features of fear extinction, which is the laboratory basis of exposure therapy. This raises uncertainties as to whether pharmacological agents that enhance fear extinction in reproductively inexperienced females are eq...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.107088
更新日期：2019-12-01 00:00:00
abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.02.008
更新日期：2009-07-01 00:00:00
abstract：:Renewal, or reinstatement, of responding to food cues after extinction may explain the inability to resist palatable foods and change maladaptive eating habits. Previously, we found sex differences in context-dependent renewal of extinguished Pavlovian conditioned responding to food cues. Context-induced renewal invol...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.12.004
更新日期：2017-03-01 00:00:00
abstract：:This article argues both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep contribute to overnight episodic memory processes but their roles differ. Episodic memory may have evolved from memory for spatial navigation in animals and humans. Equally, mnemonic navigation in world and mental space may rely ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2015.04.005
更新日期：2015-07-01 00:00:00
abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.12.023
更新日期：2017-03-01 00:00:00
abstract：:The prefrontal cortex is known to be involved in the acquisition of trace conditioning, a higher-cognitive form of Pavlovian conditioning in which a conditioned stimulus and an unconditioned stimulus are separated by a time gap. We have recently reported that medial prefrontal (mPFC) extracellular-signal regulated kin...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2004.04.006
更新日期：2004-09-01 00:00:00
abstract：:The immunotoxin 192-saporin, infused intracerebroventricularly into rats, destroys cholinergic neurons in the basal forebrain nuclei. Doses required for complete cholinergic loss also kill some Purkinje cells. The immunotoxin OX7-saporin, when infused intraventricularly into rats, destroys Purkinje cells in a pattern ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1998.3884
更新日期：1999-05-01 00:00:00
abstract：:New neurons are continually produced in the adult mammalian brain from progenitor cells located in specific brain regions, including the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. We hypothesized that neurogenesis occurs in the canine brain and is reduced with age. We examined neurogenesis in the ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.05.001
更新日期：2007-09-01 00:00:00
abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1997.3771
更新日期：1997-07-01 00:00:00
abstract：:Research on how steroid hormones mediate mnemonic processes have focused on effects of 17beta-estradiol (E(2)); yet, progesterone (P(4)) co-varies with E(2) across endogenous hormonal milieu, and itself may influence cognitive processes. We investigated the hypothesis that acute P(4) treatment enhances cognitive perfo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.03.005
更新日期：2008-07-01 00:00:00
abstract：:Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, t...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2010.08.008
更新日期：2010-11-01 00:00:00
abstract：:Primary sensory cortical fields develop highly specific associative representational plasticity, notably enlarged area of representation of reinforced signal stimuli within their topographic maps. However, overtraining subjects after they have solved an instrumental task can reduce or eliminate the expansion while the...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need f...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2017.01.009
更新日期：2017-03-01 00:00:00
abstract：:Post-training sleep benefits both declarative and procedural memory consolidation. However, recent research suggests that eyes-closed waking rest may provide a similar benefit. Brokaw et al. (2016), for example, recently demonstrated that verbal declarative memory improved more following a 15 min period of waking rest...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.06.002
更新日期：2018-11-01 00:00:00
abstract：:Complex motor skill learning, but not mere motor activity, leads to an increase in synapse number within the cerebellar cortex. The present experiment used quantitative electron microscopy to determine which synapse types were altered in number. Adult female rats were allocated to either an acrobatic condition (AC), a...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1998.3827
更新日期：1998-05-01 00:00:00
abstract：:Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2020.107355
更新日期：2021-01-01 00:00:00
abstract：:Brief physical exercise enhances memories for neutral events, and recently has been shown to modulate fear learning in animals. To date there is no evidence pertaining to the impact of exercise on emotional memories in humans. Accordingly, this study investigated the role of brief exercise in the development of emotio...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.nlm.2017.03.012
更新日期：2017-05-01 00:00:00
abstract：:The beneficial effects of caloric restriction (CR) on health and life expectancy are well documented, although its ability to slow down age-dependent cognitive decline and the underlying biochemical changes remains unclear. Therefore, the aim of this study was to investigate the effects of CR on spatial memory in aged...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.107107
更新日期：2019-12-01 00:00:00
abstract：:One of the major achievements of the last century of research in experimental psychology is the identification of a coherent set of theories and principles to characterize the nature of simple forms of associative learning. Major advances are also currently being made at a rapid pace in the neurobiology of associative...
journal_title：Neurobiology of learning and memory
pub_type： 社论
doi：10.1016/j.nlm.2013.12.006
更新日期：2014-02-01 00:00:00
