Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function.

abstract：:The authors evaluate a mapping of Rescorla and Wagner's (1972) behavioral model of classical conditioning onto the cerebellar substrates for motor reflex learning and illustrate how the limitations of the Rescorla-Wagner model are just as useful as its successes for guiding the development of new psychobiological theo...

journal_title：Neurobiology of learning and memory

authors： Gluck MA,Allen MT,Myers CE,Thompson RF

更新日期：2001-11-01 00:00:00

abstract：:There is extensive evidence that post-training administration of the adrenocortical hormone corticosterone facilitates memory consolidation processes in a variety of contextual and spatial-dependent learning situations. The present experiments examine whether corticosterone can modulate memory of auditory-cue classica...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Figueroa IR,Poytress BS,Roozendaal B,McGaugh JL,Weinberger NM

更新日期：2004-01-01 00:00:00

abstract：:In the marine snail Hermissenda, associative learning can be accomplished by paired presentations of light and vestibular stimulation. It is generally assumed that associative learning depends upon the intensity or salience of the conditioned or unconditioned stimulus (CS and US, respectively). Accordingly, during Her...

journal_title：Neurobiology of learning and memory

authors： Tomsic D,Alkon DL

更新日期：2000-07-01 00:00:00

abstract：:The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the i...

journal_title：Neurobiology of learning and memory

authors： Shymansky T,Hughes E,Rothwell CM,Lukowiak K

更新日期：2018-03-01 00:00:00

abstract：:Adult male Wistar rats with a substantia nigra pars compacta (SNc) lesion induced by intranigral administration of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used as a model of early phase Parkinson's disease (PD). This lesion caused a partial depletion of striatal dopamine (DA). The animals w...

journal_title：Neurobiology of learning and memory

authors： Bellissimo MI,Kouzmine I,Ferro MM,de Oliveira BH,Canteras NS,Da Cunha C

更新日期：2004-09-01 00:00:00

abstract：:When trained to peck a selected position in a sagittally-oriented series of identical food containers, and then required to generalize to an identical series rotated by 90°, chicks identify as correct only the target position from the left end, while choosing the right one at chance. Here we show that when accustomed ...

journal_title：Neurobiology of learning and memory

authors： Rugani R,Vallortigara G,Vallini B,Regolin L

更新日期：2011-03-01 00:00:00

abstract：:The pond snail Lymnaea stagnalis is capable of learning taste aversion by pairing presentations of a sucrose solution and an electric shock and consolidating it into long-term memory (LTM), which is referred to as conditioned taste aversion (CTA). We asked here if the neurotransmitter octopamine is involved in CTA. We...

journal_title：Neurobiology of learning and memory

authors： Aonuma H,Kaneda M,Hatakeyama D,Watanabe T,Lukowiak K,Ito E

更新日期：2017-05-01 00:00:00

abstract：:It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...

journal_title：Neurobiology of learning and memory

authors： Roesler R

更新日期：2017-07-01 00:00:00

abstract：:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanis...

journal_title：Neurobiology of learning and memory

authors： Hughes E,Shymansky T,Sunada H,Lukowiak K

更新日期：2016-12-01 00:00:00

abstract：:Sleep loss affects emotional memory, but the specific effects on its contextual and non-contextual aspects are unknown. In this study we investigated the possible differential influence of one night of sleep deprivation on the encoding and subsequent recall of these two aspects of emotional information. Forty-eight he...

journal_title：Neurobiology of learning and memory

authors： Tempesta D,Socci V,Coppo M,Dello Ioio G,Nepa V,De Gennaro L,Ferrara M

更新日期：2016-05-01 00:00:00

abstract：:Trace eyeblink conditioning requires animals to associate a neutral stimulus (CS) and an aversive periorbital shock (US) that occurred moment later. Acquisition in this conditioning depends on several forebrain regions including the hippocampus, medial prefrontal, and entorhinal cortices in addition to the cerebellum....

journal_title：Neurobiology of learning and memory

authors： Shearkhani O,Takehara-Nishiuchi K

更新日期：2013-02-01 00:00:00

abstract：:The present study investigated whether the selective nociceptin opioid peptide (NOP) receptor agonist, Ro64-6198, impairs acquisition of fear conditioning through glutamatergic mechanisms. Systemic administration of Ro64-6198 (0.3 and 1mg/kg) or the non-competitive NMDA receptor antagonist, MK-801 (0.03 and 0.1mg/kg) ...

journal_title：Neurobiology of learning and memory

authors： Goeldner C,Reiss D,Wichmann J,Kieffer BL,Ouagazzal AM

更新日期：2009-05-01 00:00:00

abstract：:Traditional learning theory has developed models that can accurately predict and describe the course of learned behavior. These "psychological process" models rely on hypothetical constructs that are usually thought to be not directly measurable or manipulable. Recently, and mostly in parallel, the neural mechanisms u...

journal_title：Neurobiology of learning and memory

authors： Fanselow MS,Zelikowsky M,Perusini J,Barrera VR,Hersman S

更新日期：2014-02-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:Most models of human and animal learning assume that learning is proportional to the discrepancy between a delivered outcome and the outcome predicted by all cues present during that trial (i.e., total error across a stimulus compound). This total error reduction (TER) view has been implemented in connectionist and ar...

journal_title：Neurobiology of learning and memory

authors： Witnauer JE,Urcelay GP,Miller RR

更新日期：2014-02-01 00:00:00

abstract：:Cognitive impairments are amongst the most debilitating deficits of schizophrenia and the best predictor of functional outcome. Schizophrenia is hypothesized to have a neurodevelopmental origin, making animal models of neurodevelopmental insult important for testing predictions that early insults will impair cognitive...

journal_title：Neurobiology of learning and memory

authors： O'Reilly KC,Perica MI,Fenton AA

更新日期：2016-10-01 00:00:00

abstract：:Goal-directed navigation is believed to be the combined product of idiothetic and allothetic orientation. Although both navigation systems require the hippocampal formation, it is probable that different circuits implement them. Examination of Long-Evans rats with dentate gyrus lesions induced by neonatal X-ray irradi...

journal_title：Neurobiology of learning and memory

authors： Czéh B,Stuchlik A,Wesierska M,Cimadevilla JM,Pokorný J,Seress L,Bures J

更新日期：2001-03-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are critically involved in various learning mechanisms including modulation of fear memory, brain development and brain disorders. While NMDARs mediate opposite effects on medial prefrontal cortex (mPFC) interneurons and excitatory neurons, NMDAR antagonists trigger profound cor...

journal_title：Neurobiology of learning and memory

authors： Vieira PA,Corches A,Lovelace JW,Westbrook KB,Mendoza M,Korzus E

更新日期：2015-03-01 00:00:00

abstract：:Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders, with rising incidence but little effective therapeutic intervention available. Currently two main clinical features are described to diagnose ASDs: impaired social interaction and communication, and repetitive behaviors. Much work has...

journal_title：Neurobiology of learning and memory

authors： Pasciuto E,Borrie SC,Kanellopoulos AK,Santos AR,Cappuyns E,D'Andrea L,Pacini L,Bagni C

更新日期：2015-10-01 00:00:00

abstract：:The beneficial effects of caloric restriction (CR) on health and life expectancy are well documented, although its ability to slow down age-dependent cognitive decline and the underlying biochemical changes remains unclear. Therefore, the aim of this study was to investigate the effects of CR on spatial memory in aged...

journal_title：Neurobiology of learning and memory

authors： Rojic-Becker D,Portero-Tresserra M,Martí-Nicolovius M,Vale-Martínez A,Guillazo-Blanch G

更新日期：2019-12-01 00:00:00

abstract：:Animals tend to repeat actions that are associated with reward delivery, whereas they tend to shift responses to alternate choices following reward omission. These so-called win-stay and lose-shift responses are employed by a wide range of animals in a variety of decision-making scenarios, and depend on dissociated re...

journal_title：Neurobiology of learning and memory

authors： Thapa R,Gruber AJ

更新日期：2018-11-01 00:00:00

abstract：:Androgens are hypothesized to enhance aspects of mnemonic processing. However, it is unclear whether the memory improvement is associated with changes in earlier aspects of information processing, such as attention. The present experiments examined the effects of gonadectomy or supplementation with testosterone or dih...

journal_title：Neurobiology of learning and memory

authors： Johnson RT,Burk JA

更新日期：2006-05-01 00:00:00

abstract：:The present work shows that the dorsomedial telencephalic pallium of teleost fish, proposed as homologous to the amygdala of mammals, is involved in taste aversion learning (TAL). To analyze the behavioral properties of TAL in goldfish, in Experiment 1, we used a delayed procedure similar to that employed with mammals...

journal_title：Neurobiology of learning and memory

authors： Martín I,Gómez A,Salas C,Puerto A,Rodríguez F

更新日期：2011-09-01 00:00:00

abstract：:Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female r...

journal_title：Neurobiology of learning and memory

authors： Fenton GE,Halliday DM,Mason R,Bredy TW,Stevenson CW

更新日期：2016-11-01 00:00:00

abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

journal_title：Neurobiology of learning and memory

authors： Kuhlmann S,Kirschbaum C,Wolf OT

更新日期：2005-03-01 00:00:00

abstract：:Cocaine experience affects motivation structures such as the nucleus accumbens (NAc) and its major output target, the ventral pallidum (VP). Previous studies demonstrated that both NAc activity and hedonic responses change reliably as a taste cue comes to predict cocaine availability. Here we extended this investigati...

journal_title：Neurobiology of learning and memory

authors： Chan CL,Wheeler DS,Wheeler RA

更新日期：2016-04-01 00:00:00

abstract：:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after traini...

journal_title：Neurobiology of learning and memory

authors： Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CA

更新日期：2002-09-01 00:00:00

abstract：:Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and/or 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, a...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-01-01 00:00:00

abstract：:Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...

journal_title：Neurobiology of learning and memory

authors： Epstein HT,Child FM,Kuzirian AM,Alkon DL

更新日期：2003-03-01 00:00:00

abstract：:ADHD and its subclinical symptoms have been associated with both disturbed sleep and weakened overnight memory consolidation. As sleep spindle activity during NREM sleep plays a key role in both sleep maintenance and memory consolidation, we examined the association between subclinical ADHD symptoms and sleep spindle ...

journal_title：Neurobiology of learning and memory

authors： Merikanto I,Kuula L,Makkonen T,Halonen R,Lahti J,Heinonen K,Räikkönen K,Pesonen AK

更新日期：2019-01-01 00:00:00