Autism Spectrum Disorders: Translating human deficits into mouse behavior.

abstract：:Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its con...

journal_title：Neurobiology of learning and memory

authors： Oyanedel CN,Sawangjit A,Born J,Inostroza M

更新日期：2019-04-01 00:00:00

abstract：:Non-selective inhibition of histone deacetylases (HDACs), enzymes that remove acetyl groups from histone core proteins, enhances cognition and NMDAR-dependent long-term potentiation at hippocampal CA3-CA1 synapses. It is not known whether this is a general mechanism by which HDACs modulate plasticity at other hippocam...

journal_title：Neurobiology of learning and memory

authors： Franklin AV,Rusche JR,McMahon LL

更新日期：2014-10-01 00:00:00

abstract：:Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus...

journal_title：Neurobiology of learning and memory

authors： Pina MM,Cunningham CL

更新日期：2017-01-01 00:00:00

abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

journal_title：Neurobiology of learning and memory

authors： Quartermain D,Garcia deSoria V

更新日期：2001-07-01 00:00:00

abstract：:The neurophysiological basis for context conditioning is conceptually problematic because neurophysiological descriptions of activity-dependent (associative) forms of neuronal plasticity uniformly assume that a specific temporal relationship between signals is necessary for memory induction. In the present experiments...

journal_title：Neurobiology of learning and memory

authors： Talk AC,Muzzio IA,Matzel LD

更新日期：1999-09-01 00:00:00

abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

journal_title：Neurobiology of learning and memory

authors： McKinney BC,Sze W,Lee B,Murphy GG

更新日期：2009-11-01 00:00:00

abstract：:It has been well established that moderate physiological or emotional arousal modulates memory. However, there is some controversy about whether the source of arousal must be semantically related to the information to be remembered. To test this idea, 35 healthy young adult participants learned a list of common nouns ...

journal_title：Neurobiology of learning and memory

authors： Nielson KA,Yee D,Erickson KI

更新日期：2005-07-01 00:00:00

abstract：:Adenosine, a purine ribonucleoside, exhibits neuromodulatory and neuroprotective effects in the brain and is involved in memory formation and cognitive function. Adenosine signaling is mediated by adenosine receptors (A1, A2A, A2B, and A3); in turn, nucleotide and nucleoside-metabolizing enzymes and adenosine transpor...

journal_title：Neurobiology of learning and memory

authors： Bortolotto JW,Melo GM,Cognato Gde P,Vianna MR,Bonan CD

更新日期：2015-02-01 00:00:00

abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...

journal_title：Neurobiology of learning and memory

authors： Shors TJ

更新日期：2006-03-01 00:00:00

abstract：:Androgens can have performance-enhancing effects in some cognitive tasks, but the mechanism of these effects has not been established. Experiments examined whether androgens' actions to bind to intracellular androgen receptors (ARs) in the hippocampus are necessary to enhance cognitive performance in the inhibitory av...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-02-01 00:00:00

abstract：:Rett syndrome is an autism spectrum disorder and a leading cause of severe mental retardation in girls. The nature of the cognitive abnormalities in Rett, as described in humans and other animal models, and its potential reversibility and treatment are the subject of this review. Rett syndrome is associated with sever...

journal_title：Neurobiology of learning and memory

authors： Berger-Sweeney J

更新日期：2011-11-01 00:00:00

abstract：:In spite of evidence about negative effects of Nandrolone Decanoate (ND) on cognitive and memory performance, the underlying mechanisms are complex and have remained unclear. This research examines the role of Calcineurin in synaptic plasticity and memory storage impairment in ND administrated adolescent male rats. Fo...

journal_title：Neurobiology of learning and memory

authors： Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2019-09-01 00:00:00

abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...

journal_title：Neurobiology of learning and memory

authors： Chatburn A,Lushington K,Kohler MJ

更新日期：2021-01-15 00:00:00

abstract：:MsrB1 belongs to the methionine sulfoxide reductase family, it is also known as selenoprotein R for the sake of possessing a selenocysteine residue. It has been reported that MsrB1 could interact with actin, TRPM6, clusterin, and amyloid-beta in vitro. Thus, we presumed that MsrB1 may play an important role in central...

journal_title：Neurobiology of learning and memory

authors： Shi T,Yang Y,Zhang Z,Zhang L,Song J,Ping Y,Du X,Song G,Liu Q,Li N

更新日期：2019-12-01 00:00:00

abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...

journal_title：Neurobiology of learning and memory

authors： Foilb AR,Flyer-Adams JG,Maier SF,Christianson JP

更新日期：2016-10-01 00:00:00

abstract：:Performing sequences of movements is a ubiquitous skill that involves dopamine transmission. However, it is unclear which components of the dopamine system contribute to which aspects of motor sequence learning. Here we used a genetic approach to investigate the relationship between different components of the dopamin...

journal_title：Neurobiology of learning and memory

authors： Baetu I,Burns NR,Urry K,Barbante GG,Pitcher JB

更新日期：2015-11-01 00:00:00

abstract：:Nitric oxide (NO) is a highly labile chemical messenger which has previously been implicated in memory processes in a variety of learning paradigms and species. However, there is only limited evidence to suggest which enzymes are acted upon by NO during the formation of memory. The present study investigates the role ...

journal_title：Neurobiology of learning and memory

authors： Edwards TM,Rickard NS,Ng KT

更新日期：2002-05-01 00:00:00

abstract：:Three experiments studied the effectiveness of ketamine acting as an aversive unconditioned stimulus (UCS) in a conditioned flavor aversion procedure. In Experiment 1a, three conditioning trials where sucrose was paired with ketamine produced a weak but significant aversion to sucrose; Experiment 1b showed that this e...

journal_title：Neurobiology of learning and memory

authors： Aguado L,del Valle R,Pérez L

更新日期：1997-09-01 00:00:00

abstract：:In the marine snail Hermissenda, associative learning can be accomplished by paired presentations of light and vestibular stimulation. It is generally assumed that associative learning depends upon the intensity or salience of the conditioned or unconditioned stimulus (CS and US, respectively). Accordingly, during Her...

journal_title：Neurobiology of learning and memory

authors： Tomsic D,Alkon DL

更新日期：2000-07-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

journal_title：Neurobiology of learning and memory

authors： Stilling RM,Fischer A

更新日期：2011-07-01 00:00:00

abstract：:Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...

journal_title：Neurobiology of learning and memory

authors： Buttigieg A,Flores O,Hernández A,Sáez-Briones P,Burgos H,Morgan C

更新日期：2014-01-01 00:00:00

abstract：:Different exercise paradigms show differential effects on various forms of memory. We hypothesize that the differential effects of exercises on memory performance are caused by different neuroplasticity changes in relevant brain regions in response to different exercise trainings. We examined the effects of treadmill ...

journal_title：Neurobiology of learning and memory

authors： Lin TW,Chen SJ,Huang TY,Chang CY,Chuang JI,Wu FS,Kuo YM,Jen CJ

更新日期：2012-01-01 00:00:00

abstract：:The selective norepinephrine (NE) α2A-adrenoceptor (α2A-AR) agonist, guanfacine (Intuniv™), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story. Guanfacine is also widely used off-label in additional mental disorders that involve impa...

journal_title：Neurobiology of learning and memory

authors： Arnsten AFT

更新日期：2020-12-01 00:00:00

abstract：:Medial thalamic damage is a common cause of severe memory disruption in humans. Both the anterior thalamic nuclei (ATN) and the intralaminar thalamic nuclei (ILN) have been suggested as primary sites of diencephalic injury underlying learning and memory deficits, but their respective roles have yet to be resolved. The...

journal_title：Neurobiology of learning and memory

authors： Wolff M,Gibb SJ,Cassel JC,Dalrymple-Alford JC

更新日期：2008-07-01 00:00:00

abstract：:Electrolytic lesions centered on the amygdaloid central nucleus (ACe) resulted in the inability of rats to acquire a Pavlovian conditional vocalization response. Conditioning consisted of pairing a light conditional stimulus with a tailshock unconditional stimulus (US). The thresholds of three unconditional responses ...

journal_title：Neurobiology of learning and memory

authors： Borszcz GS,Leaton RN

更新日期：2003-05-01 00:00:00

abstract：:Viral infection during early stage of life influences brain development and results in several neurodevelopmental disorders such as schizophrenia, autism and behavioral abnormalities. However, the mechanism through which infection causes long-term behavioral defects is not well known. To elucidate this, we have used s...

journal_title：Neurobiology of learning and memory

authors： Baghel MS,Singh B,Dhuriya YK,Shukla RK,Patro N,Khanna VK,Patro IK,Thakur MK

更新日期：2018-11-01 00:00:00

abstract：:Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, t...

journal_title：Neurobiology of learning and memory

authors： Cai R,Zhou X,Guo F,Xu J,Zhang J,Sun X

更新日期：2010-11-01 00:00:00

abstract：:Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in differ...

journal_title：Neurobiology of learning and memory

authors： Obiang P,Maubert E,Bardou I,Nicole O,Launay S,Bezin L,Vivien D,Agin V

更新日期：2011-09-01 00:00:00

abstract：:Previous evidence suggests that a high-salt (HS) diet may increase oxidative stress and contribute to the development of hypertension that is already present. Oxidative stress is thought to play a critical role in the development of neurodegenerative diseases. Lower dietary sodium intake putatively contributes to a lo...

journal_title：Neurobiology of learning and memory

authors： Liu YZ,Chen JK,Li ZP,Zhao T,Ni M,Li DJ,Jiang CL,Shen FM

更新日期：2014-10-01 00:00:00